Small Intestinal Tuft Cell Activity Associates With Energy Metabolism in Diet-Induced Obesity

Research output: Contribution to journalJournal articlepeer-review

Standard

Small Intestinal Tuft Cell Activity Associates With Energy Metabolism in Diet-Induced Obesity. / Arora, Pankaj; Andersen, Daniel; Moll, Janne Marie; Danneskiold-Samsøe, Niels Banhos; Xu, Liqin; Zhou, Biaofeng; Kladis, Georgios; Rausch, Philipp; Workman, Christopher T.; Kristiansen, Karsten; Brix, Susanne.

In: Frontiers in Immunology, Vol. 12, 629391, 2021.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Arora, P, Andersen, D, Moll, JM, Danneskiold-Samsøe, NB, Xu, L, Zhou, B, Kladis, G, Rausch, P, Workman, CT, Kristiansen, K & Brix, S 2021, 'Small Intestinal Tuft Cell Activity Associates With Energy Metabolism in Diet-Induced Obesity', Frontiers in Immunology, vol. 12, 629391. https://doi.org/10.3389/fimmu.2021.629391

APA

Arora, P., Andersen, D., Moll, J. M., Danneskiold-Samsøe, N. B., Xu, L., Zhou, B., Kladis, G., Rausch, P., Workman, C. T., Kristiansen, K., & Brix, S. (2021). Small Intestinal Tuft Cell Activity Associates With Energy Metabolism in Diet-Induced Obesity. Frontiers in Immunology, 12, [629391]. https://doi.org/10.3389/fimmu.2021.629391

Vancouver

Arora P, Andersen D, Moll JM, Danneskiold-Samsøe NB, Xu L, Zhou B et al. Small Intestinal Tuft Cell Activity Associates With Energy Metabolism in Diet-Induced Obesity. Frontiers in Immunology. 2021;12. 629391. https://doi.org/10.3389/fimmu.2021.629391

Author

Arora, Pankaj ; Andersen, Daniel ; Moll, Janne Marie ; Danneskiold-Samsøe, Niels Banhos ; Xu, Liqin ; Zhou, Biaofeng ; Kladis, Georgios ; Rausch, Philipp ; Workman, Christopher T. ; Kristiansen, Karsten ; Brix, Susanne. / Small Intestinal Tuft Cell Activity Associates With Energy Metabolism in Diet-Induced Obesity. In: Frontiers in Immunology. 2021 ; Vol. 12.

Bibtex

@article{3f4c4ac38661409cb237ee80af45ff10,
title = "Small Intestinal Tuft Cell Activity Associates With Energy Metabolism in Diet-Induced Obesity",
abstract = "Little is known about the involvement of type 2 immune response-promoting intestinal tuft cells in metabolic regulation. We here examined the temporal changes in small intestinal tuft cell number and activity in response to high-fat diet-induced obesity in mice and investigated the relation to whole-body energy metabolism and the immune phenotype of the small intestine and epididymal white adipose tissue. Intake of high fat diet resulted in a reduction in overall numbers of small intestinal epithelial and tuft cells and reduced expression of the intestinal type 2 tuft cell markers Il25 and Tslp. Amongst >1,700 diet-regulated transcripts in tuft cells, we observed an early association between body mass expansion and increased expression of the gene encoding the serine protease inhibitor neuroserpin. By contrast, tuft cell expression of genes encoding gamma aminobutyric acid (GABA)-receptors was coupled to Tslp and Il25 and reduced body mass gain. Combined, our results point to a possible role for small intestinal tuft cells in energy metabolism via coupled regulation of tuft cell type 2 markers and GABA signaling receptors, while being independent of type 2 immune cell involvement. These results pave the way for further studies into interventions that elicit anti-obesogenic circuits via small intestinal tuft cells.",
keywords = "GABA, gut-brain axis, high fat diet, metabolism, neuroserpin, tuft cells, type 2 immune responses",
author = "Pankaj Arora and Daniel Andersen and Moll, {Janne Marie} and Danneskiold-Sams{\o}e, {Niels Banhos} and Liqin Xu and Biaofeng Zhou and Georgios Kladis and Philipp Rausch and Workman, {Christopher T.} and Karsten Kristiansen and Susanne Brix",
year = "2021",
doi = "10.3389/fimmu.2021.629391",
language = "English",
volume = "12",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Small Intestinal Tuft Cell Activity Associates With Energy Metabolism in Diet-Induced Obesity

AU - Arora, Pankaj

AU - Andersen, Daniel

AU - Moll, Janne Marie

AU - Danneskiold-Samsøe, Niels Banhos

AU - Xu, Liqin

AU - Zhou, Biaofeng

AU - Kladis, Georgios

AU - Rausch, Philipp

AU - Workman, Christopher T.

AU - Kristiansen, Karsten

AU - Brix, Susanne

PY - 2021

Y1 - 2021

N2 - Little is known about the involvement of type 2 immune response-promoting intestinal tuft cells in metabolic regulation. We here examined the temporal changes in small intestinal tuft cell number and activity in response to high-fat diet-induced obesity in mice and investigated the relation to whole-body energy metabolism and the immune phenotype of the small intestine and epididymal white adipose tissue. Intake of high fat diet resulted in a reduction in overall numbers of small intestinal epithelial and tuft cells and reduced expression of the intestinal type 2 tuft cell markers Il25 and Tslp. Amongst >1,700 diet-regulated transcripts in tuft cells, we observed an early association between body mass expansion and increased expression of the gene encoding the serine protease inhibitor neuroserpin. By contrast, tuft cell expression of genes encoding gamma aminobutyric acid (GABA)-receptors was coupled to Tslp and Il25 and reduced body mass gain. Combined, our results point to a possible role for small intestinal tuft cells in energy metabolism via coupled regulation of tuft cell type 2 markers and GABA signaling receptors, while being independent of type 2 immune cell involvement. These results pave the way for further studies into interventions that elicit anti-obesogenic circuits via small intestinal tuft cells.

AB - Little is known about the involvement of type 2 immune response-promoting intestinal tuft cells in metabolic regulation. We here examined the temporal changes in small intestinal tuft cell number and activity in response to high-fat diet-induced obesity in mice and investigated the relation to whole-body energy metabolism and the immune phenotype of the small intestine and epididymal white adipose tissue. Intake of high fat diet resulted in a reduction in overall numbers of small intestinal epithelial and tuft cells and reduced expression of the intestinal type 2 tuft cell markers Il25 and Tslp. Amongst >1,700 diet-regulated transcripts in tuft cells, we observed an early association between body mass expansion and increased expression of the gene encoding the serine protease inhibitor neuroserpin. By contrast, tuft cell expression of genes encoding gamma aminobutyric acid (GABA)-receptors was coupled to Tslp and Il25 and reduced body mass gain. Combined, our results point to a possible role for small intestinal tuft cells in energy metabolism via coupled regulation of tuft cell type 2 markers and GABA signaling receptors, while being independent of type 2 immune cell involvement. These results pave the way for further studies into interventions that elicit anti-obesogenic circuits via small intestinal tuft cells.

KW - GABA

KW - gut-brain axis

KW - high fat diet

KW - metabolism

KW - neuroserpin

KW - tuft cells

KW - type 2 immune responses

U2 - 10.3389/fimmu.2021.629391

DO - 10.3389/fimmu.2021.629391

M3 - Journal article

C2 - 34122403

AN - SCOPUS:85107664963

VL - 12

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 629391

ER -

ID: 272644199