Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

Research output: Contribution to journalJournal articlepeer-review

Standard

Somatostatin venom analogs evolved by fish-hunting cone snails : From prey capture behavior to identifying drug leads. / Ramiro, Iris Bea L; Bjørn-Yoshimoto, Walden E; Imperial, Julita S; Gajewiak, Joanna; Salcedo, Paula Flórez; Watkins, Maren; Taylor, Dylan; Resager, William; Ueberheide, Beatrix; Bräuner-Osborne, Hans; Whitby, Frank G; Hill, Christopher P; Martin, Laurent F; Patwardhan, Amol; Concepcion, Gisela P; Olivera, Baldomero M; Safavi-Hemami, Helena.

In: Science Advances, Vol. 8, No. 12, eabk1410, 2022.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Ramiro, IBL, Bjørn-Yoshimoto, WE, Imperial, JS, Gajewiak, J, Salcedo, PF, Watkins, M, Taylor, D, Resager, W, Ueberheide, B, Bräuner-Osborne, H, Whitby, FG, Hill, CP, Martin, LF, Patwardhan, A, Concepcion, GP, Olivera, BM & Safavi-Hemami, H 2022, 'Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads', Science Advances, vol. 8, no. 12, eabk1410. https://doi.org/10.1126/sciadv.abk1410

APA

Ramiro, I. B. L., Bjørn-Yoshimoto, W. E., Imperial, J. S., Gajewiak, J., Salcedo, P. F., Watkins, M., Taylor, D., Resager, W., Ueberheide, B., Bräuner-Osborne, H., Whitby, F. G., Hill, C. P., Martin, L. F., Patwardhan, A., Concepcion, G. P., Olivera, B. M., & Safavi-Hemami, H. (2022). Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads. Science Advances, 8(12), [eabk1410]. https://doi.org/10.1126/sciadv.abk1410

Vancouver

Ramiro IBL, Bjørn-Yoshimoto WE, Imperial JS, Gajewiak J, Salcedo PF, Watkins M et al. Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads. Science Advances. 2022;8(12). eabk1410. https://doi.org/10.1126/sciadv.abk1410

Author

Ramiro, Iris Bea L ; Bjørn-Yoshimoto, Walden E ; Imperial, Julita S ; Gajewiak, Joanna ; Salcedo, Paula Flórez ; Watkins, Maren ; Taylor, Dylan ; Resager, William ; Ueberheide, Beatrix ; Bräuner-Osborne, Hans ; Whitby, Frank G ; Hill, Christopher P ; Martin, Laurent F ; Patwardhan, Amol ; Concepcion, Gisela P ; Olivera, Baldomero M ; Safavi-Hemami, Helena. / Somatostatin venom analogs evolved by fish-hunting cone snails : From prey capture behavior to identifying drug leads. In: Science Advances. 2022 ; Vol. 8, No. 12.

Bibtex

@article{14ef7d5a7fb44fb98641b60a1930173a,
title = "Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads",
abstract = "Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specific systemic physiological effects in prey. The increased metabolic stability, distinct SS receptor activation profiles, and chemical diversity of the venom analogs make them suitable leads for therapeutic application, including pain, cancer, and endocrine disorders. Our findings not only establish the existence of SS-like peptides in animal venoms but also serve as a model for the synergy gained from combining molecular phylogenetics and behavioral observations to optimize the discovery of natural products with biomedical potential.",
author = "Ramiro, {Iris Bea L} and Bj{\o}rn-Yoshimoto, {Walden E} and Imperial, {Julita S} and Joanna Gajewiak and Salcedo, {Paula Fl{\'o}rez} and Maren Watkins and Dylan Taylor and William Resager and Beatrix Ueberheide and Hans Br{\"a}uner-Osborne and Whitby, {Frank G} and Hill, {Christopher P} and Martin, {Laurent F} and Amol Patwardhan and Concepcion, {Gisela P} and Olivera, {Baldomero M} and Helena Safavi-Hemami",
year = "2022",
doi = "10.1126/sciadv.abk1410",
language = "English",
volume = "8",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "12",

}

RIS

TY - JOUR

T1 - Somatostatin venom analogs evolved by fish-hunting cone snails

T2 - From prey capture behavior to identifying drug leads

AU - Ramiro, Iris Bea L

AU - Bjørn-Yoshimoto, Walden E

AU - Imperial, Julita S

AU - Gajewiak, Joanna

AU - Salcedo, Paula Flórez

AU - Watkins, Maren

AU - Taylor, Dylan

AU - Resager, William

AU - Ueberheide, Beatrix

AU - Bräuner-Osborne, Hans

AU - Whitby, Frank G

AU - Hill, Christopher P

AU - Martin, Laurent F

AU - Patwardhan, Amol

AU - Concepcion, Gisela P

AU - Olivera, Baldomero M

AU - Safavi-Hemami, Helena

PY - 2022

Y1 - 2022

N2 - Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specific systemic physiological effects in prey. The increased metabolic stability, distinct SS receptor activation profiles, and chemical diversity of the venom analogs make them suitable leads for therapeutic application, including pain, cancer, and endocrine disorders. Our findings not only establish the existence of SS-like peptides in animal venoms but also serve as a model for the synergy gained from combining molecular phylogenetics and behavioral observations to optimize the discovery of natural products with biomedical potential.

AB - Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specific systemic physiological effects in prey. The increased metabolic stability, distinct SS receptor activation profiles, and chemical diversity of the venom analogs make them suitable leads for therapeutic application, including pain, cancer, and endocrine disorders. Our findings not only establish the existence of SS-like peptides in animal venoms but also serve as a model for the synergy gained from combining molecular phylogenetics and behavioral observations to optimize the discovery of natural products with biomedical potential.

U2 - 10.1126/sciadv.abk1410

DO - 10.1126/sciadv.abk1410

M3 - Journal article

C2 - 35319982

VL - 8

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 12

M1 - eabk1410

ER -

ID: 301354778