Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance.

Research output: Contribution to journalJournal articlepeer-review

Standard

Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance. / Madsen, Lise; Guerre-Millo, Michéle; Flindt, Esben N; Berge, Kjetil; Tronstad, Karl Johan; Bergene, Elin; Sebokova, Elena; Rustan, Arild C; Jensen, Jørgen; Mandrup, Susanne; Kristiansen, Karsten; Klimes, Iwar; Staels, Bart; Berge, Rolf K.

In: Journal of Lipid Research, Vol. 43, No. 5, 2002, p. 742-50.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Madsen, L, Guerre-Millo, M, Flindt, EN, Berge, K, Tronstad, KJ, Bergene, E, Sebokova, E, Rustan, AC, Jensen, J, Mandrup, S, Kristiansen, K, Klimes, I, Staels, B & Berge, RK 2002, 'Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance.', Journal of Lipid Research, vol. 43, no. 5, pp. 742-50.

APA

Madsen, L., Guerre-Millo, M., Flindt, E. N., Berge, K., Tronstad, K. J., Bergene, E., Sebokova, E., Rustan, A. C., Jensen, J., Mandrup, S., Kristiansen, K., Klimes, I., Staels, B., & Berge, R. K. (2002). Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance. Journal of Lipid Research, 43(5), 742-50.

Vancouver

Madsen L, Guerre-Millo M, Flindt EN, Berge K, Tronstad KJ, Bergene E et al. Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance. Journal of Lipid Research. 2002;43(5):742-50.

Author

Madsen, Lise ; Guerre-Millo, Michéle ; Flindt, Esben N ; Berge, Kjetil ; Tronstad, Karl Johan ; Bergene, Elin ; Sebokova, Elena ; Rustan, Arild C ; Jensen, Jørgen ; Mandrup, Susanne ; Kristiansen, Karsten ; Klimes, Iwar ; Staels, Bart ; Berge, Rolf K. / Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance. In: Journal of Lipid Research. 2002 ; Vol. 43, No. 5. pp. 742-50.

Bibtex

@article{0f57d1b0f75411ddbf70000ea68e967b,
title = "Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance.",
abstract = "Tetradecylthioacetic acid (TTA) is a non-beta-oxidizable fatty acid analog, which potently regulates lipid homeostasis. Here we evaluate the ability of TTA to prevent diet-induced and genetically determined adiposity and insulin resistance. In Wistar rats fed a high fat diet, TTA administration completely prevented diet-induced insulin resistance and adiposity. In genetically obese Zucker (fa/fa) rats TTA treatment reduced the epididymal adipose tissue mass and improved insulin sensitivity. All three rodent peroxisome proliferator-activated receptor (PPAR) subtypes were activated by TTA in the ranking order PPARalpha > PPARdelta > PPARgamma. Expression of PPARgamma target genes in adipose tissue was unaffected by TTA treatment, whereas the hepatic expression of PPARalpha-responsive genes encoding enzymes involved in fatty acid uptake, transport, and oxidation was induced. This was accompanied by increased hepatic mitochondrial beta-oxidation and a decreased fatty acid/ketone body ratio in plasma. These findings indicate that PPARalpha-dependent mechanisms play a pivotal role, but additionally, the involvement of PPARalpha-independent pathways is conceivable. Taken together, our results suggest that a TTA-induced increase in hepatic fatty acid oxidation and ketogenesis drains fatty acids from blood and extrahepatic tissues and that this contributes significantly to the beneficial effects of TTA on fat mass accumulation and peripheral insulin sensitivity.",
author = "Lise Madsen and Mich{\'e}le Guerre-Millo and Flindt, {Esben N} and Kjetil Berge and Tronstad, {Karl Johan} and Elin Bergene and Elena Sebokova and Rustan, {Arild C} and J{\o}rgen Jensen and Susanne Mandrup and Karsten Kristiansen and Iwar Klimes and Bart Staels and Berge, {Rolf K}",
year = "2002",
language = "English",
volume = "43",
pages = "742--50",
journal = "Journal of Lipid Research",
issn = "0022-2275",
publisher = "American Society for Biochemistry and Molecular Biology, Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance.

AU - Madsen, Lise

AU - Guerre-Millo, Michéle

AU - Flindt, Esben N

AU - Berge, Kjetil

AU - Tronstad, Karl Johan

AU - Bergene, Elin

AU - Sebokova, Elena

AU - Rustan, Arild C

AU - Jensen, Jørgen

AU - Mandrup, Susanne

AU - Kristiansen, Karsten

AU - Klimes, Iwar

AU - Staels, Bart

AU - Berge, Rolf K

PY - 2002

Y1 - 2002

N2 - Tetradecylthioacetic acid (TTA) is a non-beta-oxidizable fatty acid analog, which potently regulates lipid homeostasis. Here we evaluate the ability of TTA to prevent diet-induced and genetically determined adiposity and insulin resistance. In Wistar rats fed a high fat diet, TTA administration completely prevented diet-induced insulin resistance and adiposity. In genetically obese Zucker (fa/fa) rats TTA treatment reduced the epididymal adipose tissue mass and improved insulin sensitivity. All three rodent peroxisome proliferator-activated receptor (PPAR) subtypes were activated by TTA in the ranking order PPARalpha > PPARdelta > PPARgamma. Expression of PPARgamma target genes in adipose tissue was unaffected by TTA treatment, whereas the hepatic expression of PPARalpha-responsive genes encoding enzymes involved in fatty acid uptake, transport, and oxidation was induced. This was accompanied by increased hepatic mitochondrial beta-oxidation and a decreased fatty acid/ketone body ratio in plasma. These findings indicate that PPARalpha-dependent mechanisms play a pivotal role, but additionally, the involvement of PPARalpha-independent pathways is conceivable. Taken together, our results suggest that a TTA-induced increase in hepatic fatty acid oxidation and ketogenesis drains fatty acids from blood and extrahepatic tissues and that this contributes significantly to the beneficial effects of TTA on fat mass accumulation and peripheral insulin sensitivity.

AB - Tetradecylthioacetic acid (TTA) is a non-beta-oxidizable fatty acid analog, which potently regulates lipid homeostasis. Here we evaluate the ability of TTA to prevent diet-induced and genetically determined adiposity and insulin resistance. In Wistar rats fed a high fat diet, TTA administration completely prevented diet-induced insulin resistance and adiposity. In genetically obese Zucker (fa/fa) rats TTA treatment reduced the epididymal adipose tissue mass and improved insulin sensitivity. All three rodent peroxisome proliferator-activated receptor (PPAR) subtypes were activated by TTA in the ranking order PPARalpha > PPARdelta > PPARgamma. Expression of PPARgamma target genes in adipose tissue was unaffected by TTA treatment, whereas the hepatic expression of PPARalpha-responsive genes encoding enzymes involved in fatty acid uptake, transport, and oxidation was induced. This was accompanied by increased hepatic mitochondrial beta-oxidation and a decreased fatty acid/ketone body ratio in plasma. These findings indicate that PPARalpha-dependent mechanisms play a pivotal role, but additionally, the involvement of PPARalpha-independent pathways is conceivable. Taken together, our results suggest that a TTA-induced increase in hepatic fatty acid oxidation and ketogenesis drains fatty acids from blood and extrahepatic tissues and that this contributes significantly to the beneficial effects of TTA on fat mass accumulation and peripheral insulin sensitivity.

M3 - Journal article

C2 - 11971945

VL - 43

SP - 742

EP - 750

JO - Journal of Lipid Research

JF - Journal of Lipid Research

SN - 0022-2275

IS - 5

ER -

ID: 10243259