The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets

Research output: Contribution to journalJournal articlepeer-review

Standard

The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets. / Fjære, Even; Myrmel, Lene Secher; Dybing, Karianne; Kuda, Ondrej; Jensen, Benjamin Anderschou Holbech; Rossmeisl, Martin; Frøyland, Livar; Kristiansen, Karsten; Madsen, Lise.

In: Nutrients, Vol. 12, No. 10, 3038, 2020.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Fjære, E, Myrmel, LS, Dybing, K, Kuda, O, Jensen, BAH, Rossmeisl, M, Frøyland, L, Kristiansen, K & Madsen, L 2020, 'The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets', Nutrients, vol. 12, no. 10, 3038. https://doi.org/10.3390/nu12103038

APA

Fjære, E., Myrmel, L. S., Dybing, K., Kuda, O., Jensen, B. A. H., Rossmeisl, M., Frøyland, L., Kristiansen, K., & Madsen, L. (2020). The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets. Nutrients, 12(10), [3038]. https://doi.org/10.3390/nu12103038

Vancouver

Fjære E, Myrmel LS, Dybing K, Kuda O, Jensen BAH, Rossmeisl M et al. The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets. Nutrients. 2020;12(10). 3038. https://doi.org/10.3390/nu12103038

Author

Fjære, Even ; Myrmel, Lene Secher ; Dybing, Karianne ; Kuda, Ondrej ; Jensen, Benjamin Anderschou Holbech ; Rossmeisl, Martin ; Frøyland, Livar ; Kristiansen, Karsten ; Madsen, Lise. / The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets. In: Nutrients. 2020 ; Vol. 12, No. 10.

Bibtex

@article{4334f98f56d6458db348414c77eadc8a,
title = "The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets",
abstract = "Fillets from marine fish species contain n-3 polyunsaturated fatty acids (PUFAs) in the form of phospholipids (PLs). To investigate the importance of PL-bound n-3 PUFAs in mediating the anti-obesogenic effect of lean seafood, we compared the anti-obesogenic properties of fillets from cod with fillets from pangasius, a fresh water fish with a very low content of PL-bound n-3 PUFAs. We prepared high-fat/high-protein diets using chicken, cod and pangasius as the protein sources, and fed male C57BL/6J mice these diets for 12 weeks. Mice fed the diet containing cod gained less adipose tissue mass and had smaller white adipocytes than mice fed the chicken-containing diet, whereas mice fed the pangasius-containing diet were in between mice fed the chicken-containing diet and mice fed the cod-containing diet. Of note, mice fed the pangasius-containing diet exhibited reduced glucose tolerance compared to mice fed the cod-containing diet. Although the sum of marine n-3 PUFAs comprised less than 2% of the total fatty acids in the cod-containing diet, this was sufficient to significantly increase the levels of eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) in mouse tissues and enhance production of n-3 PUFA-derived lipid mediators as compared with mice fed pangasius or chicken.",
keywords = "DHA, Endocannabinoids, EPA, Marine protein source, N-3 PUFA, Nutrition, Obesity and mice, Phospholipids, Seafood",
author = "Even Fj{\ae}re and Myrmel, {Lene Secher} and Karianne Dybing and Ondrej Kuda and Jensen, {Benjamin Anderschou Holbech} and Martin Rossmeisl and Livar Fr{\o}yland and Karsten Kristiansen and Lise Madsen",
year = "2020",
doi = "10.3390/nu12103038",
language = "English",
volume = "12",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "10",

}

RIS

TY - JOUR

T1 - The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets

AU - Fjære, Even

AU - Myrmel, Lene Secher

AU - Dybing, Karianne

AU - Kuda, Ondrej

AU - Jensen, Benjamin Anderschou Holbech

AU - Rossmeisl, Martin

AU - Frøyland, Livar

AU - Kristiansen, Karsten

AU - Madsen, Lise

PY - 2020

Y1 - 2020

N2 - Fillets from marine fish species contain n-3 polyunsaturated fatty acids (PUFAs) in the form of phospholipids (PLs). To investigate the importance of PL-bound n-3 PUFAs in mediating the anti-obesogenic effect of lean seafood, we compared the anti-obesogenic properties of fillets from cod with fillets from pangasius, a fresh water fish with a very low content of PL-bound n-3 PUFAs. We prepared high-fat/high-protein diets using chicken, cod and pangasius as the protein sources, and fed male C57BL/6J mice these diets for 12 weeks. Mice fed the diet containing cod gained less adipose tissue mass and had smaller white adipocytes than mice fed the chicken-containing diet, whereas mice fed the pangasius-containing diet were in between mice fed the chicken-containing diet and mice fed the cod-containing diet. Of note, mice fed the pangasius-containing diet exhibited reduced glucose tolerance compared to mice fed the cod-containing diet. Although the sum of marine n-3 PUFAs comprised less than 2% of the total fatty acids in the cod-containing diet, this was sufficient to significantly increase the levels of eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) in mouse tissues and enhance production of n-3 PUFA-derived lipid mediators as compared with mice fed pangasius or chicken.

AB - Fillets from marine fish species contain n-3 polyunsaturated fatty acids (PUFAs) in the form of phospholipids (PLs). To investigate the importance of PL-bound n-3 PUFAs in mediating the anti-obesogenic effect of lean seafood, we compared the anti-obesogenic properties of fillets from cod with fillets from pangasius, a fresh water fish with a very low content of PL-bound n-3 PUFAs. We prepared high-fat/high-protein diets using chicken, cod and pangasius as the protein sources, and fed male C57BL/6J mice these diets for 12 weeks. Mice fed the diet containing cod gained less adipose tissue mass and had smaller white adipocytes than mice fed the chicken-containing diet, whereas mice fed the pangasius-containing diet were in between mice fed the chicken-containing diet and mice fed the cod-containing diet. Of note, mice fed the pangasius-containing diet exhibited reduced glucose tolerance compared to mice fed the cod-containing diet. Although the sum of marine n-3 PUFAs comprised less than 2% of the total fatty acids in the cod-containing diet, this was sufficient to significantly increase the levels of eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) in mouse tissues and enhance production of n-3 PUFA-derived lipid mediators as compared with mice fed pangasius or chicken.

KW - DHA

KW - Endocannabinoids

KW - EPA

KW - Marine protein source

KW - N-3 PUFA

KW - Nutrition

KW - Obesity and mice

KW - Phospholipids

KW - Seafood

U2 - 10.3390/nu12103038

DO - 10.3390/nu12103038

M3 - Journal article

C2 - 33022997

AN - SCOPUS:85092100136

VL - 12

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 10

M1 - 3038

ER -

ID: 251695365