The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets
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The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets. / Fjære, Even; Myrmel, Lene Secher; Dybing, Karianne; Kuda, Ondrej; Jensen, Benjamin Anderschou Holbech; Rossmeisl, Martin; Frøyland, Livar; Kristiansen, Karsten; Madsen, Lise.
In: Nutrients, Vol. 12, No. 10, 3038, 2020.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets
AU - Fjære, Even
AU - Myrmel, Lene Secher
AU - Dybing, Karianne
AU - Kuda, Ondrej
AU - Jensen, Benjamin Anderschou Holbech
AU - Rossmeisl, Martin
AU - Frøyland, Livar
AU - Kristiansen, Karsten
AU - Madsen, Lise
PY - 2020
Y1 - 2020
N2 - Fillets from marine fish species contain n-3 polyunsaturated fatty acids (PUFAs) in the form of phospholipids (PLs). To investigate the importance of PL-bound n-3 PUFAs in mediating the anti-obesogenic effect of lean seafood, we compared the anti-obesogenic properties of fillets from cod with fillets from pangasius, a fresh water fish with a very low content of PL-bound n-3 PUFAs. We prepared high-fat/high-protein diets using chicken, cod and pangasius as the protein sources, and fed male C57BL/6J mice these diets for 12 weeks. Mice fed the diet containing cod gained less adipose tissue mass and had smaller white adipocytes than mice fed the chicken-containing diet, whereas mice fed the pangasius-containing diet were in between mice fed the chicken-containing diet and mice fed the cod-containing diet. Of note, mice fed the pangasius-containing diet exhibited reduced glucose tolerance compared to mice fed the cod-containing diet. Although the sum of marine n-3 PUFAs comprised less than 2% of the total fatty acids in the cod-containing diet, this was sufficient to significantly increase the levels of eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) in mouse tissues and enhance production of n-3 PUFA-derived lipid mediators as compared with mice fed pangasius or chicken.
AB - Fillets from marine fish species contain n-3 polyunsaturated fatty acids (PUFAs) in the form of phospholipids (PLs). To investigate the importance of PL-bound n-3 PUFAs in mediating the anti-obesogenic effect of lean seafood, we compared the anti-obesogenic properties of fillets from cod with fillets from pangasius, a fresh water fish with a very low content of PL-bound n-3 PUFAs. We prepared high-fat/high-protein diets using chicken, cod and pangasius as the protein sources, and fed male C57BL/6J mice these diets for 12 weeks. Mice fed the diet containing cod gained less adipose tissue mass and had smaller white adipocytes than mice fed the chicken-containing diet, whereas mice fed the pangasius-containing diet were in between mice fed the chicken-containing diet and mice fed the cod-containing diet. Of note, mice fed the pangasius-containing diet exhibited reduced glucose tolerance compared to mice fed the cod-containing diet. Although the sum of marine n-3 PUFAs comprised less than 2% of the total fatty acids in the cod-containing diet, this was sufficient to significantly increase the levels of eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) in mouse tissues and enhance production of n-3 PUFA-derived lipid mediators as compared with mice fed pangasius or chicken.
KW - DHA
KW - Endocannabinoids
KW - EPA
KW - Marine protein source
KW - N-3 PUFA
KW - Nutrition
KW - Obesity and mice
KW - Phospholipids
KW - Seafood
U2 - 10.3390/nu12103038
DO - 10.3390/nu12103038
M3 - Journal article
C2 - 33022997
AN - SCOPUS:85092100136
VL - 12
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 10
M1 - 3038
ER -
ID: 251695365