The draft genome of mandrill (Mandrillus sphinx): an Old World monkey

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The draft genome of mandrill (Mandrillus sphinx) : an Old World monkey. / Yin, Ye; Yang, Ting; Liu, Huan; Huang, Ziheng; Zhang, Yaolei; Song, Yue; Wang, Wenliang; Guang, Xuanmin; Sahu, Sunil Kumar; Kristiansen, Karsten.

In: Scientific Reports, Vol. 10, 2431, 2020.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Yin, Y, Yang, T, Liu, H, Huang, Z, Zhang, Y, Song, Y, Wang, W, Guang, X, Sahu, SK & Kristiansen, K 2020, 'The draft genome of mandrill (Mandrillus sphinx): an Old World monkey', Scientific Reports, vol. 10, 2431. https://doi.org/10.1038/s41598-020-59110-3

APA

Yin, Y., Yang, T., Liu, H., Huang, Z., Zhang, Y., Song, Y., Wang, W., Guang, X., Sahu, S. K., & Kristiansen, K. (2020). The draft genome of mandrill (Mandrillus sphinx): an Old World monkey. Scientific Reports, 10, [2431]. https://doi.org/10.1038/s41598-020-59110-3

Vancouver

Yin Y, Yang T, Liu H, Huang Z, Zhang Y, Song Y et al. The draft genome of mandrill (Mandrillus sphinx): an Old World monkey. Scientific Reports. 2020;10. 2431. https://doi.org/10.1038/s41598-020-59110-3

Author

Yin, Ye ; Yang, Ting ; Liu, Huan ; Huang, Ziheng ; Zhang, Yaolei ; Song, Yue ; Wang, Wenliang ; Guang, Xuanmin ; Sahu, Sunil Kumar ; Kristiansen, Karsten. / The draft genome of mandrill (Mandrillus sphinx) : an Old World monkey. In: Scientific Reports. 2020 ; Vol. 10.

Bibtex

@article{a5f6e35f053a4ac5a18b5257c6cb1006,
title = "The draft genome of mandrill (Mandrillus sphinx): an Old World monkey",
abstract = "Mandrill (Mandrillus sphinx) is a primate species, which belongs to the Old World monkey (Cercopithecidae) family. It is closely related to human, serving as a model for human health related research. However, the genetic studies on and genomic resources of mandrill are limited, especially in comparison to other primate species. Here we produced 284 Gb data, providing 96-fold coverage (considering the estimated genome size of 2.9 Gb), to construct a reference genome for the mandrill. The assembled draft genome was 2.79 Gb with contig N50 of 20.48 Kb and scaffold N50 of 3.56 Mb. We annotated the mandrill genome to find 43.83% repeat elements, as well as 21,906 protein-coding genes. The draft genome was of good quality with 98% gene annotation coverage by Benchmarking Universal Single-Copy Orthologs (BUSCO). Based on comparative genomic analyses of the Major Histocompatibility Complex (MHC) of the immune system in mandrill and human, we found that 17 genes in the mandrill that have been associated with disease phenotypes in human such as Lung cancer, cranial volume and asthma, barbored amino acids changing mutations. Gene family analyses revealed expansion of several genes, and several genes associated with stress environmental adaptation and innate immunity responses exhibited signatures of positive selection. In summary, we established the first draft genome of the mandrill of value for studies on evolution and human health.",
author = "Ye Yin and Ting Yang and Huan Liu and Ziheng Huang and Yaolei Zhang and Yue Song and Wenliang Wang and Xuanmin Guang and Sahu, {Sunil Kumar} and Karsten Kristiansen",
year = "2020",
doi = "10.1038/s41598-020-59110-3",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - The draft genome of mandrill (Mandrillus sphinx)

T2 - an Old World monkey

AU - Yin, Ye

AU - Yang, Ting

AU - Liu, Huan

AU - Huang, Ziheng

AU - Zhang, Yaolei

AU - Song, Yue

AU - Wang, Wenliang

AU - Guang, Xuanmin

AU - Sahu, Sunil Kumar

AU - Kristiansen, Karsten

PY - 2020

Y1 - 2020

N2 - Mandrill (Mandrillus sphinx) is a primate species, which belongs to the Old World monkey (Cercopithecidae) family. It is closely related to human, serving as a model for human health related research. However, the genetic studies on and genomic resources of mandrill are limited, especially in comparison to other primate species. Here we produced 284 Gb data, providing 96-fold coverage (considering the estimated genome size of 2.9 Gb), to construct a reference genome for the mandrill. The assembled draft genome was 2.79 Gb with contig N50 of 20.48 Kb and scaffold N50 of 3.56 Mb. We annotated the mandrill genome to find 43.83% repeat elements, as well as 21,906 protein-coding genes. The draft genome was of good quality with 98% gene annotation coverage by Benchmarking Universal Single-Copy Orthologs (BUSCO). Based on comparative genomic analyses of the Major Histocompatibility Complex (MHC) of the immune system in mandrill and human, we found that 17 genes in the mandrill that have been associated with disease phenotypes in human such as Lung cancer, cranial volume and asthma, barbored amino acids changing mutations. Gene family analyses revealed expansion of several genes, and several genes associated with stress environmental adaptation and innate immunity responses exhibited signatures of positive selection. In summary, we established the first draft genome of the mandrill of value for studies on evolution and human health.

AB - Mandrill (Mandrillus sphinx) is a primate species, which belongs to the Old World monkey (Cercopithecidae) family. It is closely related to human, serving as a model for human health related research. However, the genetic studies on and genomic resources of mandrill are limited, especially in comparison to other primate species. Here we produced 284 Gb data, providing 96-fold coverage (considering the estimated genome size of 2.9 Gb), to construct a reference genome for the mandrill. The assembled draft genome was 2.79 Gb with contig N50 of 20.48 Kb and scaffold N50 of 3.56 Mb. We annotated the mandrill genome to find 43.83% repeat elements, as well as 21,906 protein-coding genes. The draft genome was of good quality with 98% gene annotation coverage by Benchmarking Universal Single-Copy Orthologs (BUSCO). Based on comparative genomic analyses of the Major Histocompatibility Complex (MHC) of the immune system in mandrill and human, we found that 17 genes in the mandrill that have been associated with disease phenotypes in human such as Lung cancer, cranial volume and asthma, barbored amino acids changing mutations. Gene family analyses revealed expansion of several genes, and several genes associated with stress environmental adaptation and innate immunity responses exhibited signatures of positive selection. In summary, we established the first draft genome of the mandrill of value for studies on evolution and human health.

U2 - 10.1038/s41598-020-59110-3

DO - 10.1038/s41598-020-59110-3

M3 - Journal article

C2 - 32051450

AN - SCOPUS:85079338070

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 2431

ER -

ID: 238369848