The gene expression network regulating queen brain remodeling after insemination and its parallel use in ants with reproductive workers

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The gene expression network regulating queen brain remodeling after insemination and its parallel use in ants with reproductive workers. / Nagel, Manuel; Qiu, Bitao; Brandenborg, Lisa Eigil; Larsen, Rasmus Stenbak; Ning, Dongdong; Boomsma, Jacobus Jan; Zhang, Guojie.

In: Science Advances, Vol. 6, No. 38, eaaz5772, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nagel, M, Qiu, B, Brandenborg, LE, Larsen, RS, Ning, D, Boomsma, JJ & Zhang, G 2020, 'The gene expression network regulating queen brain remodeling after insemination and its parallel use in ants with reproductive workers', Science Advances, vol. 6, no. 38, eaaz5772. https://doi.org/10.1126/sciadv.aaz5772

APA

Nagel, M., Qiu, B., Brandenborg, L. E., Larsen, R. S., Ning, D., Boomsma, J. J., & Zhang, G. (2020). The gene expression network regulating queen brain remodeling after insemination and its parallel use in ants with reproductive workers. Science Advances, 6(38), [eaaz5772]. https://doi.org/10.1126/sciadv.aaz5772

Vancouver

Nagel M, Qiu B, Brandenborg LE, Larsen RS, Ning D, Boomsma JJ et al. The gene expression network regulating queen brain remodeling after insemination and its parallel use in ants with reproductive workers. Science Advances. 2020;6(38). eaaz5772. https://doi.org/10.1126/sciadv.aaz5772

Author

Nagel, Manuel ; Qiu, Bitao ; Brandenborg, Lisa Eigil ; Larsen, Rasmus Stenbak ; Ning, Dongdong ; Boomsma, Jacobus Jan ; Zhang, Guojie. / The gene expression network regulating queen brain remodeling after insemination and its parallel use in ants with reproductive workers. In: Science Advances. 2020 ; Vol. 6, No. 38.

Bibtex

@article{8046ac618b5547198a3a81a0d8113112,
title = "The gene expression network regulating queen brain remodeling after insemination and its parallel use in ants with reproductive workers",
abstract = "Caste differentiation happens early in development to produce gynes as future colony germlines and workers as present colony soma. However, gynes need insemination to become functional queens, a transition that initiates reproductive role differentiation relative to unmated gynes. Here, we analyze the anatomy and transcriptomes of brains during this differentiation process within the reproductive caste of Monomorium pharaonis. Insemination terminated brain growth, whereas unmated control gynes continued to increase brain volume. Transcriptomes revealed a specific gene regulatory network (GRN) mediating both brain anatomy changes and behavioral modifications. This reproductive role differentiation GRN hardly overlapped with the gyne-worker caste differentiation GRN, but appears to be also used by distantly related ants where workers became germline individuals after the queen caste was entirely or partially lost. The genes corazonin and neuroparsin A in the anterior neurosecretory cells were overexpressed in individuals with reduced or nonreproductive roles across all four ant species investigated.",
author = "Manuel Nagel and Bitao Qiu and Brandenborg, {Lisa Eigil} and Larsen, {Rasmus Stenbak} and Dongdong Ning and Boomsma, {Jacobus Jan} and Guojie Zhang",
year = "2020",
doi = "10.1126/sciadv.aaz5772",
language = "English",
volume = "6",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "38",

}

RIS

TY - JOUR

T1 - The gene expression network regulating queen brain remodeling after insemination and its parallel use in ants with reproductive workers

AU - Nagel, Manuel

AU - Qiu, Bitao

AU - Brandenborg, Lisa Eigil

AU - Larsen, Rasmus Stenbak

AU - Ning, Dongdong

AU - Boomsma, Jacobus Jan

AU - Zhang, Guojie

PY - 2020

Y1 - 2020

N2 - Caste differentiation happens early in development to produce gynes as future colony germlines and workers as present colony soma. However, gynes need insemination to become functional queens, a transition that initiates reproductive role differentiation relative to unmated gynes. Here, we analyze the anatomy and transcriptomes of brains during this differentiation process within the reproductive caste of Monomorium pharaonis. Insemination terminated brain growth, whereas unmated control gynes continued to increase brain volume. Transcriptomes revealed a specific gene regulatory network (GRN) mediating both brain anatomy changes and behavioral modifications. This reproductive role differentiation GRN hardly overlapped with the gyne-worker caste differentiation GRN, but appears to be also used by distantly related ants where workers became germline individuals after the queen caste was entirely or partially lost. The genes corazonin and neuroparsin A in the anterior neurosecretory cells were overexpressed in individuals with reduced or nonreproductive roles across all four ant species investigated.

AB - Caste differentiation happens early in development to produce gynes as future colony germlines and workers as present colony soma. However, gynes need insemination to become functional queens, a transition that initiates reproductive role differentiation relative to unmated gynes. Here, we analyze the anatomy and transcriptomes of brains during this differentiation process within the reproductive caste of Monomorium pharaonis. Insemination terminated brain growth, whereas unmated control gynes continued to increase brain volume. Transcriptomes revealed a specific gene regulatory network (GRN) mediating both brain anatomy changes and behavioral modifications. This reproductive role differentiation GRN hardly overlapped with the gyne-worker caste differentiation GRN, but appears to be also used by distantly related ants where workers became germline individuals after the queen caste was entirely or partially lost. The genes corazonin and neuroparsin A in the anterior neurosecretory cells were overexpressed in individuals with reduced or nonreproductive roles across all four ant species investigated.

U2 - 10.1126/sciadv.aaz5772

DO - 10.1126/sciadv.aaz5772

M3 - Journal article

C2 - 32938672

AN - SCOPUS:85091128551

VL - 6

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 38

M1 - eaaz5772

ER -

ID: 249947756