The Retinoblastoma-Histone Deacetylase 3 Complex Inhibits PPAR¿ and Adipocyte Differentiation

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The Retinoblastoma-Histone Deacetylase 3 Complex Inhibits PPAR¿ and Adipocyte Differentiation. / Fajas, Lluis; Egler, Viviane; Reiter, Raphael; Hansen, Jacob; Kristiansen, Karsten; Debril, Marie-Bernard; Miard, Stéphanie; Auwerx, Johan.

In: Developmental Cell, Vol. 3, No. 6, 2002, p. 903-910.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Fajas, L, Egler, V, Reiter, R, Hansen, J, Kristiansen, K, Debril, M-B, Miard, S & Auwerx, J 2002, 'The Retinoblastoma-Histone Deacetylase 3 Complex Inhibits PPAR¿ and Adipocyte Differentiation', Developmental Cell, vol. 3, no. 6, pp. 903-910. https://doi.org/10.1016/S1534-5807(02)00360-X

APA

Fajas, L., Egler, V., Reiter, R., Hansen, J., Kristiansen, K., Debril, M-B., Miard, S., & Auwerx, J. (2002). The Retinoblastoma-Histone Deacetylase 3 Complex Inhibits PPAR¿ and Adipocyte Differentiation. Developmental Cell, 3(6), 903-910. https://doi.org/10.1016/S1534-5807(02)00360-X

Vancouver

Fajas L, Egler V, Reiter R, Hansen J, Kristiansen K, Debril M-B et al. The Retinoblastoma-Histone Deacetylase 3 Complex Inhibits PPAR¿ and Adipocyte Differentiation. Developmental Cell. 2002;3(6):903-910. https://doi.org/10.1016/S1534-5807(02)00360-X

Author

Fajas, Lluis ; Egler, Viviane ; Reiter, Raphael ; Hansen, Jacob ; Kristiansen, Karsten ; Debril, Marie-Bernard ; Miard, Stéphanie ; Auwerx, Johan. / The Retinoblastoma-Histone Deacetylase 3 Complex Inhibits PPAR¿ and Adipocyte Differentiation. In: Developmental Cell. 2002 ; Vol. 3, No. 6. pp. 903-910.

Bibtex

@article{f733d880a82511debc73000ea68e967b,
title = "The Retinoblastoma-Histone Deacetylase 3 Complex Inhibits PPAR¿ and Adipocyte Differentiation",
abstract = "The retinoblastoma protein (RB) has previously been shown to facilitate adipocyte differentiation by inducing cell cycle arrest and enhancing the transactivation by the adipogenic CCAAT/enhancer binding proteins (C/EBP). We show here that the peroxisome proliferator-activated receptor ¿ (PPAR¿), a nuclear receptor pivotal for adipogenesis, promotes adipocyte differentiation more efficiently in the absence of RB. PPAR¿ and RB were shown to coimmunoprecipitate, and this PPAR¿-RB complex also contains the histone deacetylase HDAC3, thereby attenuating PPAR¿'s capacity to drive gene expression and adipocyte differentiation. Dissociation of the PPAR¿-RB-HDAC3 complex by RB phosphorylation or by inhibition of HDAC activity stimulates adipocyte differentiation. These observations underscore an important function of both RB and HDAC3 in fine-tuning PPAR¿ activity and adipocyte differentiation.",
author = "Lluis Fajas and Viviane Egler and Raphael Reiter and Jacob Hansen and Karsten Kristiansen and Marie-Bernard Debril and St{\'e}phanie Miard and Johan Auwerx",
year = "2002",
doi = "10.1016/S1534-5807(02)00360-X",
language = "English",
volume = "3",
pages = "903--910",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - The Retinoblastoma-Histone Deacetylase 3 Complex Inhibits PPAR¿ and Adipocyte Differentiation

AU - Fajas, Lluis

AU - Egler, Viviane

AU - Reiter, Raphael

AU - Hansen, Jacob

AU - Kristiansen, Karsten

AU - Debril, Marie-Bernard

AU - Miard, Stéphanie

AU - Auwerx, Johan

PY - 2002

Y1 - 2002

N2 - The retinoblastoma protein (RB) has previously been shown to facilitate adipocyte differentiation by inducing cell cycle arrest and enhancing the transactivation by the adipogenic CCAAT/enhancer binding proteins (C/EBP). We show here that the peroxisome proliferator-activated receptor ¿ (PPAR¿), a nuclear receptor pivotal for adipogenesis, promotes adipocyte differentiation more efficiently in the absence of RB. PPAR¿ and RB were shown to coimmunoprecipitate, and this PPAR¿-RB complex also contains the histone deacetylase HDAC3, thereby attenuating PPAR¿'s capacity to drive gene expression and adipocyte differentiation. Dissociation of the PPAR¿-RB-HDAC3 complex by RB phosphorylation or by inhibition of HDAC activity stimulates adipocyte differentiation. These observations underscore an important function of both RB and HDAC3 in fine-tuning PPAR¿ activity and adipocyte differentiation.

AB - The retinoblastoma protein (RB) has previously been shown to facilitate adipocyte differentiation by inducing cell cycle arrest and enhancing the transactivation by the adipogenic CCAAT/enhancer binding proteins (C/EBP). We show here that the peroxisome proliferator-activated receptor ¿ (PPAR¿), a nuclear receptor pivotal for adipogenesis, promotes adipocyte differentiation more efficiently in the absence of RB. PPAR¿ and RB were shown to coimmunoprecipitate, and this PPAR¿-RB complex also contains the histone deacetylase HDAC3, thereby attenuating PPAR¿'s capacity to drive gene expression and adipocyte differentiation. Dissociation of the PPAR¿-RB-HDAC3 complex by RB phosphorylation or by inhibition of HDAC activity stimulates adipocyte differentiation. These observations underscore an important function of both RB and HDAC3 in fine-tuning PPAR¿ activity and adipocyte differentiation.

U2 - 10.1016/S1534-5807(02)00360-X

DO - 10.1016/S1534-5807(02)00360-X

M3 - Journal article

VL - 3

SP - 903

EP - 910

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 6

ER -

ID: 14640168