The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function. / Hallenborg, Philip; Feddersen, Søren; Madsen, Lise; Kristiansen, Karsten.

In: Expert Opinion On Therapeutic Targets, Vol. 13, No. 2, 2009, p. 235-46.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hallenborg, P, Feddersen, S, Madsen, L & Kristiansen, K 2009, 'The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function', Expert Opinion On Therapeutic Targets, vol. 13, no. 2, pp. 235-46. https://doi.org/10.1517/14712590802680141

APA

Hallenborg, P., Feddersen, S., Madsen, L., & Kristiansen, K. (2009). The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function. Expert Opinion On Therapeutic Targets, 13(2), 235-46. https://doi.org/10.1517/14712590802680141

Vancouver

Hallenborg P, Feddersen S, Madsen L, Kristiansen K. The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function. Expert Opinion On Therapeutic Targets. 2009;13(2):235-46. https://doi.org/10.1517/14712590802680141

Author

Hallenborg, Philip ; Feddersen, Søren ; Madsen, Lise ; Kristiansen, Karsten. / The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function. In: Expert Opinion On Therapeutic Targets. 2009 ; Vol. 13, No. 2. pp. 235-46.

Bibtex

@article{a7be08200e3811de8478000ea68e967b,
title = "The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function",
abstract = "BACKGROUND: The retinoblastoma protein (pRB) and p53 are crucial members of regulatory networks controlling the cell cycle and apoptosis, and a hallmark of virtually all cancers is dysregulation of expression or function of pRB or p53. Although they are best known for their role in cancer development, it is now evident that both are implicated in metabolism and cellular development. OBJECTIVE/METHODS: To review the role of pRB and p53 in adipocyte differentiation and function emphasizing that pRB and p53, via their effects on adipocyte development and function, play a role in the regulation of energy metabolism and homeostasis. RESULTS/CONCLUSIONS: pRB is required for adipose conversion and also involved in determining its mitochondrial capacity. p53 inhibits adipogenesis and results suggest that it is involved in maintaining function of adipose tissue.",
author = "Philip Hallenborg and S{\o}ren Feddersen and Lise Madsen and Karsten Kristiansen",
year = "2009",
doi = "10.1517/14712590802680141",
language = "English",
volume = "13",
pages = "235--46",
journal = "Expert Opinion on Therapeutic Targets",
issn = "1472-8222",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function

AU - Hallenborg, Philip

AU - Feddersen, Søren

AU - Madsen, Lise

AU - Kristiansen, Karsten

PY - 2009

Y1 - 2009

N2 - BACKGROUND: The retinoblastoma protein (pRB) and p53 are crucial members of regulatory networks controlling the cell cycle and apoptosis, and a hallmark of virtually all cancers is dysregulation of expression or function of pRB or p53. Although they are best known for their role in cancer development, it is now evident that both are implicated in metabolism and cellular development. OBJECTIVE/METHODS: To review the role of pRB and p53 in adipocyte differentiation and function emphasizing that pRB and p53, via their effects on adipocyte development and function, play a role in the regulation of energy metabolism and homeostasis. RESULTS/CONCLUSIONS: pRB is required for adipose conversion and also involved in determining its mitochondrial capacity. p53 inhibits adipogenesis and results suggest that it is involved in maintaining function of adipose tissue.

AB - BACKGROUND: The retinoblastoma protein (pRB) and p53 are crucial members of regulatory networks controlling the cell cycle and apoptosis, and a hallmark of virtually all cancers is dysregulation of expression or function of pRB or p53. Although they are best known for their role in cancer development, it is now evident that both are implicated in metabolism and cellular development. OBJECTIVE/METHODS: To review the role of pRB and p53 in adipocyte differentiation and function emphasizing that pRB and p53, via their effects on adipocyte development and function, play a role in the regulation of energy metabolism and homeostasis. RESULTS/CONCLUSIONS: pRB is required for adipose conversion and also involved in determining its mitochondrial capacity. p53 inhibits adipogenesis and results suggest that it is involved in maintaining function of adipose tissue.

U2 - 10.1517/14712590802680141

DO - 10.1517/14712590802680141

M3 - Journal article

C2 - 19236241

VL - 13

SP - 235

EP - 246

JO - Expert Opinion on Therapeutic Targets

JF - Expert Opinion on Therapeutic Targets

SN - 1472-8222

IS - 2

ER -

ID: 11206286