Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have emerged as a biotechnological tool and therapeutic. The discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPR (Acr) proteins, enables the development of more controllable and precise CRISPR-Cas tools. Here we discuss applications of Acr proteins for post-translational control of CRISPR-Cas systems in prokaryotic and mammalian cells, organisms and ecosystems.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Nature Methods |
Vol/bind | 17 |
Udgave nummer | 5 |
Sider (fra-til) | 471-479 |
Antal sider | 9 |
ISSN | 1548-7091 |
DOI | |
Status | Udgivet - 2020 |
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510557/pdf/nihms-1679494.pdf
Accepteret manuskript
ID: 239855966