De Novo Pathway Enrichment with KeyPathwayMiner
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
Biomolecular networks such as protein–protein interaction networks provide a static picture of the interplay of genes and their products, and, consequently, they fail to capture dynamic changes taking place during the development of complex diseases. KeyPathwayMiner is a software platform designed to fill this gap by integrating previous knowledge captured in molecular interaction networks with OMICS datasets (DNA microarrays, RNA sequencing, genome-wide methylation studies, etc.) to extract connected subnetworks with a high number of deregulated genes. This protocol describes how to use KeyPathwayMiner for integrated analysis of multi-omics datasets in the network analysis tool Cytoscape and in a stand-alone web application available at https://keypathwayminer.compbio.sdu.dk.
Originalsprog | Engelsk |
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Titel | Protein-Protein Interaction Networks : Methods and Protocols |
Redaktører | Stefan Canzar, Francisca Rojas Ringeling |
Antal sider | 19 |
Forlag | Humana Press |
Publikationsdato | 2020 |
Sider | 181-199 |
Kapitel | 14 |
ISBN (Trykt) | 978-1-4939-9872-2 |
ISBN (Elektronisk) | 978-1-4939-9873-9 |
DOI | |
Status | Udgivet - 2020 |
Navn | Methods in Molecular Biology |
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Vol/bind | 2074 |
ISSN | 1064-3745 |
ID: 230742618