Efflux-Pump Upregulation: From Tolerance to High-level Antibiotic Resistance?
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
A recent study shows that high expression of the efflux-pump AcrAB-TolC, which increases antibiotic tolerance, reduces DNA mismatch repair in Escherichia coli to promote spontaneous mutations. Because mutations in target genes can lead to high-level resistance, this highlights how transiently tolerant cells can develop resistance in response to antibiotic treatment.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Trends in Microbiology |
Vol/bind | 27 |
Udgave nummer | 4 |
Sider (fra-til) | 291-293 |
ISSN | 0966-842X |
DOI | |
Status | Udgivet - 2019 |
Bibliografisk note
Copyright © 2019 Elsevier Ltd. All rights reserved.
ID: 214126264