ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination
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- ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination
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Søndergaard et al. demonstrate that ERG is a critical transcriptional regulator essential for B cell development. Loss of ERG leads to a marked reduction in V-to-DJ recombination at the Igh locus, precluding B cell progenitors from expressing the pre-B cell receptor, which is required for entering the final stages of B cell development.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Cell Reports |
Vol/bind | 29 |
Udgave nummer | 9 |
Sider (fra-til) | 2756-2769.e6 |
Antal sider | 21 |
ISSN | 2211-1247 |
DOI | |
Status | Udgivet - 26 nov. 2019 |
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ID: 231505814