Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. / Kilpeläinen, Tuomas O.; Bentley, Amy R.; Noordam, Raymond; Sung, Yun Ju; Schwander, Karen; Winkler, Thomas W.; Jakupović, Hermina; Chasman, Daniel I.; Manning, Alisa; Ntalla, Ioanna; Aschard, Hugues; Brown, Michael R.; de las Fuentes, Lisa; Franceschini, Nora; Guo, Xiuqing; Vojinovic, Dina; Aslibekyan, Stella; Feitosa, Mary F.; Kho, Minjung; Musani, Solomon K.; Richard, Melissa; Wang, Heming; Wang, Zhe; Bartz, Traci M.; Bielak, Lawrence F.; Campbell, Archie; Dorajoo, Rajkumar; Fisher, Virginia; Hartwig, Fernando P.; Horimoto, Andrea R.V.R.; Li, Changwei; Lohman, Kurt K.; Marten, Jonathan; Sim, Xueling; Smith, Albert V.; Tajuddin, Salman M.; Alver, Maris; Amini, Marzyeh; Boissel, Mathilde; Chai, Jin Fang; Chen, Xu; Divers, Jasmin; Evangelou, Evangelos; Gao, Chuan; Graff, Mariaelisa; Harris, Sarah E.; He, Meian; Hsu, Fang Chi; Zhao, Jing Hua; Loos, Ruth J.F.; LifeLines Cohort Study ; V Varga, Tibor.

I: Nature Communications, Bind 10, 376, 2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Kilpeläinen, TO, Bentley, AR, Noordam, R, Sung, YJ, Schwander, K, Winkler, TW, Jakupović, H, Chasman, DI, Manning, A, Ntalla, I, Aschard, H, Brown, MR, de las Fuentes, L, Franceschini, N, Guo, X, Vojinovic, D, Aslibekyan, S, Feitosa, MF, Kho, M, Musani, SK, Richard, M, Wang, H, Wang, Z, Bartz, TM, Bielak, LF, Campbell, A, Dorajoo, R, Fisher, V, Hartwig, FP, Horimoto, ARVR, Li, C, Lohman, KK, Marten, J, Sim, X, Smith, AV, Tajuddin, SM, Alver, M, Amini, M, Boissel, M, Chai, JF, Chen, X, Divers, J, Evangelou, E, Gao, C, Graff, M, Harris, SE, He, M, Hsu, FC, Zhao, JH, Loos, RJF, LifeLines Cohort Study & V Varga, T 2019, 'Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity', Nature Communications, bind 10, 376. https://doi.org/10.1038/s41467-018-08008-w

APA

Kilpeläinen, T. O., Bentley, A. R., Noordam, R., Sung, Y. J., Schwander, K., Winkler, T. W., Jakupović, H., Chasman, D. I., Manning, A., Ntalla, I., Aschard, H., Brown, M. R., de las Fuentes, L., Franceschini, N., Guo, X., Vojinovic, D., Aslibekyan, S., Feitosa, M. F., Kho, M., ... V Varga, T. (2019). Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications, 10, [376]. https://doi.org/10.1038/s41467-018-08008-w

Vancouver

Kilpeläinen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW o.a. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications. 2019;10. 376. https://doi.org/10.1038/s41467-018-08008-w

Author

Kilpeläinen, Tuomas O. ; Bentley, Amy R. ; Noordam, Raymond ; Sung, Yun Ju ; Schwander, Karen ; Winkler, Thomas W. ; Jakupović, Hermina ; Chasman, Daniel I. ; Manning, Alisa ; Ntalla, Ioanna ; Aschard, Hugues ; Brown, Michael R. ; de las Fuentes, Lisa ; Franceschini, Nora ; Guo, Xiuqing ; Vojinovic, Dina ; Aslibekyan, Stella ; Feitosa, Mary F. ; Kho, Minjung ; Musani, Solomon K. ; Richard, Melissa ; Wang, Heming ; Wang, Zhe ; Bartz, Traci M. ; Bielak, Lawrence F. ; Campbell, Archie ; Dorajoo, Rajkumar ; Fisher, Virginia ; Hartwig, Fernando P. ; Horimoto, Andrea R.V.R. ; Li, Changwei ; Lohman, Kurt K. ; Marten, Jonathan ; Sim, Xueling ; Smith, Albert V. ; Tajuddin, Salman M. ; Alver, Maris ; Amini, Marzyeh ; Boissel, Mathilde ; Chai, Jin Fang ; Chen, Xu ; Divers, Jasmin ; Evangelou, Evangelos ; Gao, Chuan ; Graff, Mariaelisa ; Harris, Sarah E. ; He, Meian ; Hsu, Fang Chi ; Zhao, Jing Hua ; Loos, Ruth J.F. ; LifeLines Cohort Study ; V Varga, Tibor. / Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. I: Nature Communications. 2019 ; Bind 10.

Bibtex

@article{9ef8beba0cd144f6ba57f545bb07b26c,
title = "Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity",
abstract = "Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.",
author = "Kilpel{\"a}inen, {Tuomas O.} and Bentley, {Amy R.} and Raymond Noordam and Sung, {Yun Ju} and Karen Schwander and Winkler, {Thomas W.} and Hermina Jakupovi{\'c} and Chasman, {Daniel I.} and Alisa Manning and Ioanna Ntalla and Hugues Aschard and Brown, {Michael R.} and {de las Fuentes}, Lisa and Nora Franceschini and Xiuqing Guo and Dina Vojinovic and Stella Aslibekyan and Feitosa, {Mary F.} and Minjung Kho and Musani, {Solomon K.} and Melissa Richard and Heming Wang and Zhe Wang and Bartz, {Traci M.} and Bielak, {Lawrence F.} and Archie Campbell and Rajkumar Dorajoo and Virginia Fisher and Hartwig, {Fernando P.} and Horimoto, {Andrea R.V.R.} and Changwei Li and Lohman, {Kurt K.} and Jonathan Marten and Xueling Sim and Smith, {Albert V.} and Tajuddin, {Salman M.} and Maris Alver and Marzyeh Amini and Mathilde Boissel and Chai, {Jin Fang} and Xu Chen and Jasmin Divers and Evangelos Evangelou and Chuan Gao and Mariaelisa Graff and Harris, {Sarah E.} and Meian He and Hsu, {Fang Chi} and Zhao, {Jing Hua} and Loos, {Ruth J.F.} and {LifeLines Cohort Study} and {V Varga}, Tibor",
year = "2019",
doi = "10.1038/s41467-018-08008-w",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

AU - Kilpeläinen, Tuomas O.

AU - Bentley, Amy R.

AU - Noordam, Raymond

AU - Sung, Yun Ju

AU - Schwander, Karen

AU - Winkler, Thomas W.

AU - Jakupović, Hermina

AU - Chasman, Daniel I.

AU - Manning, Alisa

AU - Ntalla, Ioanna

AU - Aschard, Hugues

AU - Brown, Michael R.

AU - de las Fuentes, Lisa

AU - Franceschini, Nora

AU - Guo, Xiuqing

AU - Vojinovic, Dina

AU - Aslibekyan, Stella

AU - Feitosa, Mary F.

AU - Kho, Minjung

AU - Musani, Solomon K.

AU - Richard, Melissa

AU - Wang, Heming

AU - Wang, Zhe

AU - Bartz, Traci M.

AU - Bielak, Lawrence F.

AU - Campbell, Archie

AU - Dorajoo, Rajkumar

AU - Fisher, Virginia

AU - Hartwig, Fernando P.

AU - Horimoto, Andrea R.V.R.

AU - Li, Changwei

AU - Lohman, Kurt K.

AU - Marten, Jonathan

AU - Sim, Xueling

AU - Smith, Albert V.

AU - Tajuddin, Salman M.

AU - Alver, Maris

AU - Amini, Marzyeh

AU - Boissel, Mathilde

AU - Chai, Jin Fang

AU - Chen, Xu

AU - Divers, Jasmin

AU - Evangelou, Evangelos

AU - Gao, Chuan

AU - Graff, Mariaelisa

AU - Harris, Sarah E.

AU - He, Meian

AU - Hsu, Fang Chi

AU - Zhao, Jing Hua

AU - Loos, Ruth J.F.

AU - LifeLines Cohort Study

AU - V Varga, Tibor

PY - 2019

Y1 - 2019

N2 - Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.

AB - Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.

U2 - 10.1038/s41467-018-08008-w

DO - 10.1038/s41467-018-08008-w

M3 - Journal article

C2 - 30670697

AN - SCOPUS:85060388984

VL - 10

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 376

ER -

ID: 213239251