Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  • Niels Hadrup
  • Kristina Bram Knudsen
  • Trine Berthing
  • Henrik Wolff
  • Stefan Bengtson
  • Christian Kofoed
  • Roall Espersen
  • Casper Højgaard
  • Winther, Jakob R.
  • Willemoës, Martin
  • Irene Wedin
  • Markus Nuopponen
  • Harri Alenius
  • Hannu Norppa
  • Håkan Wallin
  • Ulla Vogel

We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE NFC, 2–20 μm in length, 2–15 nm in width, 2) AS (−COOH), carboxylated, 0.5–10 μm in length, 4–10 nm in width, containing the biocide BIM MC4901 and 3) BIOCID FINE NFC: as (1) but containing BIM MC4901. FINE NFC administration increased neutrophil influx in BAL and induced SAA3 in plasma. AS (−COOH) produced lower neutrophil influx and systemic SAA3 levels than FINE NFC. Results obtained with BIOCID FINE NFC suggested that BIM MC4901 biocide did not explain the lowered response. Increased DNA damage levels were observed across materials, doses and time points. In conclusion, carboxylation of nanofibrillated cellulose was associated with reduced pulmonary and systemic toxicity, suggesting involvement of OH groups in the inflammatory and acute phase responses.

OriginalsprogEngelsk
TidsskriftEnvironmental Toxicology and Pharmacology
Vol/bind66
Sider (fra-til)116-125
Antal sider10
ISSN1382-6689
DOI
StatusUdgivet - 2019

ID: 212858405