NHE1 Group Publications – Department of Biology - University of Copenhagen

Stine Falsig Pedersen > NHE1 Group Publications

Publications - Stine Falsig Pedersen (March 2018)

Original research articles

  1. Pedersen SF, Kramhøft B, Jørgensen NK, Hoffmann EK. 1996. Shrinkage-induced activation of the Na+/H+ exchanger in Ehrlich ascites tumor cells: Mechanisms involved in the activation and a role for the exchanger in cell volume regulation. J Membrane Biol 149: 141-159
  2. Basavappa S, Pedersen SF, Jørgensen NK, Ellory JC, Hoffmann, E.K. 1998. Swelling-induced arachidonic acid release via 85 kDa cPLA2 in human neuroblastoma cells. J. Neurophysiol 79:1441-1449
  3. Pedersen SF, Jørgensen NK, Damgaard, I., Schousboe A, Hoffmann EK 1998. Mechanisms of pHi regulation studied in individual neurons cultured from mouse cerebral cortex. J. Neurosci Res 51: 431-441
  4. Litman T, Pedersen SF, Kramhøft B, Skovsgaard T, Hoffmann EK. 1998. pH regulation in sensitive and multidrug resistant Ehrlich ascites tumor cells. Cell Physiol Biochem 8: 138-150
  5. Pedersen SF, Jørgensen NK, Hoffmann EK. 1998. Dynamics of Ca2+i and pHi in Ehrlich ascites tumor cells after Ca2+ mobilizing agents or exposure to hypertonic  solution. Pflügers Arch - Eur J Physiol 436:199-210
  6. Pedersen SF, Prenen J, Droogmans G, Hoffmann EK, Nilius B. 1998. Separate swelling- and Ca2+ activated anion currents in Ehrlich ascites tumor cells. J Membrane Biol 163: 97-110
  7. Pedersen SF, Pedersen S, Lambert IH, Hoffmann EK. 1998. P2 receptor mediated signal transduction in Ehrlich ascites tumor cells. Biochim Biophys Acta 1374: 94-106
  8. Pedersen S, Pedersen SF, Nilius B, Lambert IH, Hoffmann EK. 1999. Mechanical stress induces release of ATP from Ehrlich ascites tumor cells. Biochim Biophys Acta 1416: 271-284
  9. Jørgensen NK, Pedersen SF, Hoffmann, E.K. 1999. Thrombin-, bradykinin- and arachidonic acid-induced Ca2+-signalling in Ehrlich ascites tumor cells. Am. J. Physiol. 276:C26-C37
  10. Jørgensen NK, Pedersen SF, Damgaard I, Schousboe A, Hoffmann EK. 1999. Increases in [Ca2+]i  and changes in intracellular pH during chemical hypoxia in mouse neocortical neurons in primary culture. J Neurosci Res 56: 358-370
  11. Pedersen SF, Mills JW, Hoffmann EK. 1999. Role of the F-actin cytoskeleton in the RVD and RVI processes in Ehrlich Ascites tumor cells. Exp Cell Res 252: 63-74
  12. Mills JW, Pedersen SF, Walmod PS, Hoffmann EK. 2000. Effect of cytochalasins on F-actin and morphology of Ehrlich Ascites tumor cells. Exp Cell Res 261:209-219
  13. Hochstrasser B, Isaksen PM, Koponen H, Lauritzen L, Mahnert FA, Rouillon F, Wade AG, Andersen M, Pedersen SF, de Swart JCG, Nil R. 2001. Prophylactic effect of citalopram in unipolar, recurrent depression: A placebo-controlled study on maintenance therapy. Br.J. Psychiatry 178: 304-310
  14. Pedersen SF, Beisner KH, Hougaard C, Willumsen BM, Lambert IH, Hoffmann EK. 2002. Rho family GTP binding proteins are involved in the Regulatory Volume Decrease process in NIH3T3 mouse fibroblasts. J. Physiol. (Lond.) 541.3: 779-796
  15. Pedersen SF and Hoffmann EK. 2002. Possible interrelationship between changes in F-actin and myosin II, protein phosphorylation and cell volume regulation in Ehrlich ascites tumor cells. Exp. Cell Res. 277:57-73
  16. Lionetto MG, Pedersen SF, Hoffmann EK, Giordano ME, Schettino T.  2002. Roles of the cytoskeleton and of protein phosphorylation events in the osmotic stress response in eel intestinal epithelium. Cell Physiol. Biochem. 12:163-178
  17. Pedersen SF, Varming C, Christensen ST, Hoffmann EK. 2002. Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells. J. Membrane Biol. 189:67-81
  18. Pedersen SF, King SA, Rigor RR, Zhuang Z, Warren JM, Cala PM. 2003. Molecular cloning of NHE1 from Winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A. Am. J. Physiol. Cell Physiol., 284:C1561-C1576
  19. Jorgensen NK, Pedersen SF, Rasmussen HB, Grunnet M, Olesen SP, Klaerke DA. 2003. Cell swelling activates cloned Ca2+-activated K+ channels: A role for the F-actin cytoskeleton. Biochim. Biophys. Acta, 1615:115-125
  20. Nylandsted J, Jäättelä M, Hoffmann EK, Pedersen SF. 2004. Hsp70 protects fibrosarcoma cells against shrinkage-induced programmed cell death via a mechanism independent of effects on cell volume-regulatory membrane transport proteins. Pflügers Archiv, 449:175-185
  21. Voss JW, Pedersen SF, Christensen ST, Lambert IH. 2004. Regulation of the expression and subcellular localisation of the taurine transporter TauT in mouse NIH3T3 fibroblasts. Eur. J. Biochem. 271: 1–13
  22. Lambert IH and Pedersen SF. 2005. Multiple PLA2 isoforms regulate taurine release in NIH3T3 mouse fibroblasts. In: S.S. Oja & P. Saransaari ( eds ) Taurine 6 – Taurine Today . Kluwer Academic/Plenum Publisher , New York, NY, USA
  23. Holt MEV, King SA, Cala PM, Pedersen SF. 2006. Regulation of the Pleuronectes Americanus Na+/H+ exchanger, paNHE1, by osmotic shrinkage, b-adrenergic stimuli, and inhibition of Ser/Thr protein phosphatases. Cell Biochem Biophys, 45(1):1-18
  24. Pedersen SF, Poulsen KA, Lambert IH. 2006. Roles of phospholipase A2 isoforms in the swelling- and melittin-induced arachidonic acid and taurine release in NIH3T3 cells. Am J Physiol Cell Physiol, 291(6):C1286-96
  25. Klausen T K, Hougaard C, Hoffmann EK, Pedersen SF. 2006. Cholesterol modulates the volume regulated anion current in Ehrlich Lettre Ascites cells via effects on Rho and F-actin. Am. J. Physiol. Cell Physiol, 291(4):C757-71
  26. Klausen TK, Hougaard C, Christophersen P, Pedersen SF, Hoffmann EK. 2007. Cell cycle-dependent activity of the volume- and Ca2+-activated anion currents in Ehrlich Lettre Ascites Cells. J. Cell Physiol. 210(3):831-842
  27. Hoffmann EK and Pedersen SF. 2007. Shrinkage-insensitivity of NKCC1 in myosin II-depleted cytoplasts from Ehrlich ascites tumor cells. Am J Physiol. Cell Physiol, 292(5): 1854-66.
  28. Rentsch ML, Ossum CG, Hoffmann EK, Pedersen SF. 2007. Roles of the Na+/H+ exchanger, NHE1, in regulation of p38 mitogen activated protein kinase and cell death after chemical anoxia in NIH3T3 fibroblasts. Pflügers Archiv 454(4):649-62
  29. Pedersen SF, King SA, Nygaard EB, Rigor RR, Cala PM. 2007. NHE1 inhibition by amiloride- and benzoyl guanidine-type compounds: Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. J. Biol. Chem., 282(27):19716-27
  30. Pedersen SF, Darborg BV, Rasmussen M, Nylandsted J, Hoffmann EK. 2007. The Na+/H+ exchanger, NHE1, differentially regulates mitogen-activated protein kinase subfamilies after osmotic shrinkage in Ehrlich Lettre Ascites cells. Cell Physiol Biochem, 20(6):735-750
  31. Poulsen KA, Pedersen SF, Kolko M, Lambert IH. 2007. Induction of group VIA calcium-independent phospholipase A2 activity during in vitro ischemia in C2C12 myotubes involves changes in the level of its splice variants. Am J Physiol, 293(5):C1605-15
  32. Schneider L, Klausen TK, Stock C, Mally S, Christensen ST, Pedersen SF, Hoffmann EK, Schwab S. 2008. H-ras transformation sensitizes volume-activated Cl- channels, leading to increased migratory capacity of NIH3T3 fibroblasts. Pflügers Archiv 455(6):1055-62
  33. Rasmussen M, Alexander RT, Darborg BV, Møbjerg N, Hoffmann EK, Kapus A, Pedersen SF. 2008. Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: Activation mechanisms and physiological implications. Am. J. Physiol. Cell Physiol. 294(1):C197-212
  34. Thirone ACP, Speight P, Zulys M, Rotstein OD, Szászi K, Pedersen SF, Kapus A. 2009. Hyperosmotic stress induces Rho-Rho kinase-LIM kinase-mediated cofilin phosphorylation in tubular cells: central role in the osmotically triggered F- actin respons. Am J Physiol Cell Physiol, 296(3):C463-75
  35. Schneider L, Stock CM ,Dieterich P, Satir P, Schwab A, Christensen ST, Pedersen SF. 2009. The Na+/H+ exchanger, NHE1, plays a central role in directed fibroblast migration stimulated by PDGFRa signalling in the primary cilium. J. Cell Biol., 185(1):163-76
  36. Andersen AD, Poulsen KA, Lambert IH, Pedersen SF. 2009. HL-1 mouse cardiomyocyte injury and death after simulated ischemia and reperfusion: roles of pH, Ca2+-independent phospholipase A2, and Na+/H+ exchange. Am J Physiol, 296(5):C1227-42
  37. Klausen KK, Pagani A, Minassi A, Ech-Chahad A, Prenen J, Owsianik G, Hoffmann EK, Pedersen SF, Appendino G, Nilius B. 2009. Modulation of the Transient Receptor Potential Channel TRPV4 by 4α Phorbol Esters. A structure-Activity study. J Med Chem, 14;52(9):2933-9
  38. Andresen L, Hansen KA, Jensen H, Pedersen SF, Stougaard P, Ødum N, Hansen HR, Skov S. 2009. Propionic acid secreted from Propionibacteria induce NKG2D-ligand expression on human activated T lymphocytes and cancer cells. J. Immunol, 183(2):897-906
  39. Lauritzen G, Jensen MBF, Boedtkjaer E, Aalkjaer C, Nylandsted J, Pedersen SF. 2010. NBCn1 and NHE1 expression and activity in DNErbB2 receptor-expressing MCF-7 breast cancer cells:  contributions to pHi regulation and chemotherapy resistance. Exp Cell Research, 316, 2538-2553
  40. Kjaergaard M, Nørholm AB, Hendus-Altenburger R, Pedersen SF, Poulsen FM, Kragelund BB. 2010. Temperature dependent structural changes in intrinsically disordered proteins: Formation of α-helices or loss of polyproline II? Protein Science 19, 1555-1564
  41. Klausen TK, Preisler S, Pedersen SF, Hoffmann EK. 2010. Monovalent Ions Control Proliferation of Ehrlich Lettre Ascites cells. Am J Physiol Cell Physiol 299(3):C714-25
  42. Nygaard EB, Lagerstedt JO, Bjerre G, Shi B, Budamagunta M, Poulsen KA, Meinild S, Rigor RR, Voss JC, Cala PM, Pedersen SF. 2011. Structural modelling and electron paramagnetic resonance spectroscopy of the human Na+/H+ exchanger isoform 1. J Biol Chem 286:634-48
  43. Gorbatenko A, Wiwel M, Klingberg H, Nielsen AB, Kapus A, Pedersen SF. 2011. Hyperosmotic stress regulates the protein kinases RSK and MSK and transcription factors CREB and SRF: implications for osmotic regulation of gene transcription. J Cell Physiol 226(11):2857-68
  44. Martin C, Pedersen SF, Schwab A, Stock C. 2011. Intracellular pH gradients in migrating cells. Am J Physiol Cell Physiol 300(3):C490-5
  45. Nørholm AB, Hendus-Altenburger R, Bjerre G, Kjaergaard M, Pedersen SF, Kragelund BB. 2011. The intracellular distal tail of the Na+/H+ exchanger NHE1 is intrinsically disordered: implications for NHE1 trafficking. Biochemistry 50(17):3469-80
  46. Schrøder JM, Larsen J, Komarova Y, Akhmanova A, Thorsteinsson RI, Christensen ST, Pedersen SF, Geimer S, Pedersen LB. 2011. EB3 is required for assembly of primary cilia and affects the formation of centriole-associated rootlet filaments. J Cell Sci 124(Pt 15):2539-51
  47. Andersen AD, Bentzen BH, Salling H, Klingberg H, Kanneworff M, Grunnet M, Pedersen SF. 2011. The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na+/H+ exchanger NHE1. Cell Physiol Biochem 28(1):13-24
  48. Eduardsen K, Larsen SL, Novak I, Lambert IH, Hoffmann EK, Pedersen SF. 2011. Cell Volume Regulation and Signaling in 3T3-L1 Pre-adipocytes and Adipocytes: On the Possible Roles of Caveolae, Insulin Receptors, FAK and ERK1/2. Cell Physiol Biochem 28(6):1231-46
  49. Madsen CP, Klausen TK, Fabian A, Pedersen SF, Hoffmann EK. 2011. On the role of TRPC1 in control of Ca2+ influx, cell volume and cell cycle. Am J Physiol Cell Physiol 303(6):C625-34
  50. Lauritzen L, Stock CM, Lund SF, Jensen MF, Damsgaard B, Petersen KS, Dybboe R, Wiwel M, Ronnov-Jessen L, Schwab A, Pedersen SF. 2012. The Na+/H+ exchanger NHE1, but not the Na+,HCO3- cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2. Cancer Letters 317(2):172-83
  51. Larsen AM, Krogsgaard-Larsen N, Lauritzen G, Olesen CW, Boedtkjer E, Pedersen SF, Bunch L. 2012. Gram-Scale Solution-Phase Synthesis of Selective Sodium Bicarbonate Cotransport Inhibitor S0859: In Vitro Efficacy Studies in Breast Cancer Cells. ChemMedChem; 7(10):1808-14
  52. Boedtkjer E,  Moreira J, Mele M, Vahl P, Wielenga VT, Christiansen PM, Jensen V, Pedersen SF, Aalkjaer C. 2013. Na+,HCO3--cotransport is a major determinant of intracellular pH in human breast cancer: an emerging role for NBCn1 (SLC4A7). Int J Cancer 132(6):1288-99
  53. Ly DL, Waheed F, Lodyga M, Speight P, Masszi A, Nakano H, Hersom M, Pedersen SF, Szaszi K, Kapus A. Hyperosmotic stress regulates the distribution and stability of Myocardin-Related Transcription Factor, a key modulator of the cytoskeleton. 2013. Am J Physiol Cell Physiol. 304(2):C115-27
  54. Storm P, Kjaer Klausen T, Trulsson M, Ho Cs J, Dosnon M, Westergren T, Chao Y, Rydström A, Yang H, Pedersen SF, Svanborg C. 2013. A Unifying Mechanism for Cancer Cell Death through Ion Channel Activation by HAMLET. PLoS One.;8(3):e58578
  55. Clement DL, Mally S, Stock C, Lethan M, Satir P, Schwab A, Pedersen SF, Christensen ST. 2013. PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways. J Cell Sci.;126(Pt 4):953-65
  56. Veland IR, Montjean R, Eley L, Pedersen LB, Schwab A, Goodship J, Kristiansen K, Pedersen SF, Saunier S, Christensen ST. Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration. 2013. PLoS One, 8(4):e60193.
  57. Gorbatenko A, Olesen CW, Moerup N, Thiel G, Kallunki T, Valen E, Pedersen SF. 2014. ErbB2 upregulates the Na+,HCO3--cotransporter NBCn1/SLC4A7 in human breast cancer cells via Akt1, ERK2, and Krüppel-like factor 4. FASEB J, 28(1):350-63.
  58. Klausen KK, Janssens A, Prenen J, Owsianik G, Hoffmann EK, Pedersen SF, Nilius B. 2013 Single point mutations of aromatic residues in transmembrane helices 5 and -6 differentially affect TRPV4 activation by 4alpha-PDD and hypotonicity: implications for the role of the pore region in regulating TRPV4 activity. Cell Calcium, S0143-4160(13)00145-0.
  59. Schreml S, Meier RJ, KirschbaumM, Kong SC, Gehmert S, Felthaus O, Küchler S, Sharpe JR, Wöltje K, Weiß KT, Albert M, Seidl U, Schröder J, Morsczeck C, Prantl L, Duschl-C, Pedersen SF, Gosau M, Wolfbeis OS, Landthaler M, Babilas P. 2013. Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair. Theranostics. 2014; 4(7):721-35
  60. Sigurðsson HH, Olesen CW, Dybboe R, Lauritzen G, Pedersen SF. 2015. Constitutively active ErbB2 regulates cisplatin-induced cell death in MCF-7 breast cancer cells via both pro- and anti-apoptotic mechanisms Mol. Cancer Res, 13(1):63-77
  61. Sauter DR, Novak I, Pedersen SF, Larsen EH, Hoffmann EK. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015. 467(7):1495-508
  62. Rasmussen LJH, Müller, HSH, Jørgensen B, Pedersen SF, Hoffmann EK.  Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells. 2015. Am J Physiol Cell Physiol. 308(2):C101-10
  63. Haxholm GW, Nikolajsen LF, Olsen JG, Fredsted J, Larsen FH, Goffin V, Pedersen SF, Brooks AJ, Waters MJ, Kragelund B. 2015. Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes. Biochem J, 468 (3) 495-506
  64. Pedraz-Cuesta E, Christensen S, Jensen AA, Jensen NF, Bunch L, Romer MU, Brünner N, Stenvang J, Pedersen SF. 2015. The glutamate transport inhibitor dl-TBOA differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells. BMC Cancer 15, 411, DOI 10.1186/s12885-015-1405-8
  65. Lee S, Axelsen TV, Andersen AP, Vahl P, Pedersen SF, Boedtkjer E. 2016. Disrupting Na+,HCO3 -cotransporter NBCn1 (Slc4a7) delays murine breast cancer development. Oncogene, 35(16):2112-22
  66. Nielsen BS, Malinda RR, Schmid FM, Pedersen SF, Christensen ST, Pedersen LB. 2015. PDGFRα and oncogenic, mutant PDGFRα D842V) promote disassembly of primary cilia by a PLCγ and AURKA dependent mechanism.  J Cell Sci, 128(19):3543-9
  67. Nadeem A, Sanborn J, Gettel D, Ngassam V, Ho J, Rydström A, Klausen TK, Pedersen SF, Parikh A, Svanborg C. 2015. Protein receptor-independent plasma membrane remodeling by HAMLET; a tumoricidal protein-lipid complex. Sci Rep. 5:16432
  68. Kong SC, Nøhr-Nielsen A, Zeeberg K, Reshkin S, Hoffmann EK, Novak I, Pedersen SF. 2016. Monocarboxylate transporters MCT1 and MCT4 regulate migration and invasion of Pancreatic Ductal Adenocarcinoma Cells. Pancreas. 45(7):1036-4
  69. Rozycki M,  Bialik JF, Speight P,  Knudsen TET, Dan Q,  Szeto SG, Yuen DA,  Szászi K, Pedersen SF, Kapus A. Myocardin-related transcription factor regulates Nox4 expression: linking cytoskeletal organization to redox state.  J Biol Chem. 291(1):227-43
  70. Giannuzzo A, Pedersen SF, Novak I. 2015. The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells. Mol. Cancer 14(1):203
  71. Hendus-Altenburger R, Pedraz-Cuesta E, Olesen CW, Papaleo E, Schnell JA, Hopper JT, Robinson CV, Pedersen SF, Kragelund BB.The human Na+/H+ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2. BMC Biol. 2016 Apr 15;14:31. doi: 10.1186/s12915-016-0252-7.
  72. Zeeberg K, Cardone RA, Greco MR, Saccomano M, Nohr-Nielsen A, Alves F, Pedersen SF, Reshkin SJ. Assessment of different 3D culture systems to study tumor phenotype and chemosensitivity in pancreatic ductal adenocarcinoma (PDAC). Int. J. Oncol., 49(1):243-52
  73. Pedraz-Cuesta E, Fredsted J, Jensen HH, Bornebusch A, Nejsum LN, Kragelund BB, Pedersen SF. 2015. Prolactin signaling stimulates invasion via the Na+/H+ exchanger NHE1 in T47D human breast cancer cells. Mol.Endocrinol., 30(7):693-708
  74. Andersen AP, Flinck M, Oernbo EK, Pedersen NB, Viuff MB, Pedersen SF. 2015. Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment. Mol Cancer, 6;15(1):45
  75. Gorbatenko A, Loebl N, Sigurdsson HH, Bianchi C, Olesen CW, Pedraz-Cuesta E, Pedersen SF. 2016. Oncogenic p95HER2 regulates Na+-HCO3- cotransporter NBCn1 mRNA stability in breast cancer cells via 3’UTR dependent processes. Biochemical J, 473(21):4027-4044.
  76. Newie I, Søkilde R, Persson H, Jacomasso T, Gorbatenko A, Borg Å, de Hoon M, Pedersen SF, Rovira C. 2016. HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5. Sci Rep 2016; 6:35664 doi: 10.1038/srep35664
  77. Miranda MZ, Bialik JF, Speight P, Dan Q, Yeung T, Szászi K, Pedersen SF, Kapus A. TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism. J Biol Chem. 2017 Sep 8;292(36):14902-14920. doi: 10.1074/jbc.M117.780502.
  78. Hendus-Altenburger R, Lambrughi M, Terkelsen T, Pedersen SF, Papaleo E, Lindorff-Larsen K, Kragelund BB. A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1). Cell Signal. 2017;37:40-51. doi: 10.1016/j.cellsig.2017.05.015.
  79. Pedersen AK, Mendes Lopes de Melo J, Mørup N, Tritsaris K, Pedersen SF. 2017. Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer. BMC Cancer; 17(1):542. doi: 10.1186/s12885-017-3532-x
  80. Petersen C, Nielsen MD, Andersen ES, Basse AL, Isidor MS, Markussen LK, Viuff BM, Lambert IH, Hansen JB, Pedersen SF. 2017. MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism. Sci Rep.; 7(1):13101. doi: 10.1038/s41598-017-13298-z
  81. Andersen AP, Samsoe-Petersen J, Oernboe EK, Boedtkjer E, Moreira JMA, Kveiborg K, Pedersen SF. 2018. The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms. Int J Cancer (epub ahead of print) doi: 10.1002/ijc.31276
  82. Olesen CW, Vogensen J, Pedersen IS, Stemann JHV, Schröder JM, Christensen DP, Pedersen SF. 2018. Trafficking, localization and degradation of the Na+,HCO3- cotransporter NBCn1 in kidney and breast epithelial cells. Sci Rep, resubmitted after revision
  83. Gorbatenko A, Soekilde R, Newie I, Persson H, Morancho B, Arribas J, Litman T, Rovira C, Pedersen SF. 2018. HER2 and p95HER2 differentially regulate global miRNA expression in MCF-7 breast cancer cells and downregulate MYB family proteins through miR-221/222 and miR-503. Sci Rep, in revision
  84. Lee S, Axelsen TV, Jessen N, Pedersen SF, Vahl P, Boedtkjer E. 2018. Na+,HCO3-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice. Oncogene, in revision
  85. Flinck M., Kramer S.H., Schnipper J, Andersen AP, Pedersen SF. 2018. The acid-base transport proteins NHE1 and NBCn1 regulate cell cycle progression in human breast cancer cells. Cell Cycle, resubmitted after revision

Review articles

  1. Hoffmann EK and Pedersen SF. 1998. Sensors and signal transduction in the activation of cell volume regulatory ion transport systems. Contrib Nephrol 123: 58-78
  2. Pedersen SF, Hoffmann EK, Mills JW. 2001. The cytoskeleton and cell volume regulation. Comp Biochem Physiol, 130: 385-399
  3. Pedersen SF and Cala PM. 2004. Comparative biology of the ubiquitous Na+/H+ exchanger, NHE1: lessons from erythrocytes. J. Exp. Zool., 301A:569-578
  4. Pedersen SF, Owsianik G, Nilius B. 2005. TRP channels: an overview. Cell Calcium 38: 233-252
  5. Pedersen SF. 2006. The Na+/H+ exchanger NHE1 in stress-induced signal transduction: Implications for cell proliferation and cell death. Pflügers Archiv (Eur J Physiol). 452(3):249-59
  6. Lambert IH, Pedersen SF, Poulsen KA. 2006. Activation of PLA2 isoforms by Cell Swelling and Ischemia/Hypoxia. Acta Physiol  187:75-85
  7. Hoffmann EK, Lambert IH, Pedersen SF. 2006. Editorial: 12th Acta Physiologica International Symposium ‘Cell volume control in health and disease’ Acta Physiol. 187:1-3
  8. Pedersen SF, O’Donnell ME, Anderson SE, Cala PM. 2006. Physiology and Pathophysiology of Na+/H+ exchange and Na+,K+,2Cl- cotransport. Am J Physiol Reg Int Comp Physiol 291(1):R1-25
  9. Hoffmann EK and Pedersen SF. 2006. Sensors and signal transduction pathways in vertebrate cell volume regulation. Contrib Nephrol 152:54-104
  10. Pedersen SF, Darborg BV, Rentsch ML, and Rasmussen M. 2007. Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1. Arch Biochem Biophys, 462(2):195-201 
  11. Pedersen SF, Nilius B. 2007. Transient Receptor Potential channels in mechanosensing and cell volume regulation. Meth Enz., 428:183-207
  12. Christensen ST, Pedersen SF, Satir P, Veland IR, Schneider L. 2008. The primary cilium coordinates cell cycle control and migration during development and tissue repair. Curr Top Dev Biol;85:261-301
  13. Lambert IH, Hoffmann EK, Pedersen SF. 2008. Cell volume regulation: Physiology and Pathophysiology.  Acta Physiol, 194(4):255-82.
  14. Hoffmann EK, Lambert, IH, Pedersen SF. 2009. Mechanisms and physiology of cell volume regulation in vertebrates. Physiological Reviews 89(1):193-277
  15. Hoffmann EK and Pedersen SF. 2010. Cell volume homeostatic mechanisms in vertebrates: Effectors and signalling pathways. Acta Physiologica  (Oxf.) 202(3):465-85
  16. Pedersen SF, Kapus A, Hoffmann EK. 2011. Osmosensory mechanisms in cellular and systemic volume regulation J Am Soc Nephrol, 22(9):1587-97
  17. Boedtkjer E, Bunch L, Pedersen SF. 2012. Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: Similarities, differences, and implications for cancer therapy. Curr. Pharmacol. Des, 18(10):1345-71
  18. Andersen AP, Moreira J, Pedersen SF. 2014. Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment. Philos Trans R Soc Lond B Biol Sci. 369(1638):20130098
  19. Pedersen SF, Hoffmann EK, Novak I. 2013. Cell volume regulation in epithelial physiology and cancer. Frontiers Physiol. 4:233
  20. Gorbatenko A, Olesen CW, Boedtkjer E, Pedersen SF. 2014. Regulation and roles of bicarbonate transport in cancer. Frontiers Physiol., 5:130
  21. Hendus-Altenburger R, Kragelund BB, Pedersen SF. 2014. Structural dynamics and regulation of mammalian SLC9A family sodium-proton exchangers. Curr Top Membranes, 2014;73:69-148.
  22. Kong SC, Gianuzzo A, Novak I, Pedersen SF. 2014. Acid-base transport in pancreatic cancer: Molecular mechanisms and clinical potential. Biochemistry and Cell Biology. 92(6):449-59
  23. Pedersen SF, Klausen KK, Nilius B. 2015. The identification of a volume-regulated anion channel: an amazing Odyssey. Acta Physiol. 213(4):868-81
  24. Pedersen NB, Carlsson MC, Pedersen SF. 2015. Glycosylation of Solute Carriers: Mechanisms and functional consequences. Pflügers Archiv 468(2):159-76
  25. Pedersen SF, Okada Y, Nilius B. 2016. Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR). Pflugers Archiv. 468(3):371-83
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