Jakob R. Winther
Ole Maaløes Vej 5
2200 København N
Telefon: 35 32 15 00
Jakob R. Winther vil være en god mentor
for studerende med interesse for:
Proteinkemi, mikrobiel screening og genetiske metoder, proteinoprensning og karakterisering, metabolisme.
The scientific work has throughout focused on combining protein chemistry and molecular genetics but has also covered more basic biophysical aspects of protein structure and function as well as enzymology. The main areas of experience include redox metabolism and disulfide bond formation as well as protein structure, function and engineering. One of the significant contributions has been the design and implementation of a redox sensitive variant of GFP. This has later evolved into several projects involving protein design. In addition, protease function and activity has been an important area of interest in particular in terms of specificity and activation and inhibition and most recently this work has involved the study to understand the substrate specificity of HIV protease.
In the recent years the development and understanding of tools for improving protein design, both basic and applied, has become an increasingly important area of research.