ATP signaling in inflammation and cancer

Hovedområde:Cell biology
 
Målgruppe:Molecular Biomedicine, Biology, Biochemistry
 
Niveau:Masters, Bachelor
 
Projektbeskrivelse:

ATP is the molecule of life. Inside the cell it provides energy and participates in many essential processes. Outside the cell it acts as a short-range and “evolutionary old” signaling molecule. This so called Purinergic Signalling involves a number of membrane-bound specific receptors, enzymes and ATP release mechanisms. These processes are important both at the cellular level and in physiology, and play a role in inflammation, cancer and also obesity and diabetes.

The overall objective of our research is to increase the understanding of the role of ATP outside/inside of cells and pin down the relevance to inflammation and pancreatic cancer. We have the following focus areas and interdisciplinary projects:

•       Purinergic signaling in pancreatic cancer and fibrosis

•       Role of ATP signaling in cellular crosstalk in the tumor microenvironment

•       Role of P2X7 receptors in inflammasome activation  

The projects are offered at MSc and BSc level in the above research areas, and we have wide national and international collaborations. We use a wide spectrum of approaches and techniques ranging from the molecular to organismal level. In particular we are experienced in advanced imaging techniques, and our group runs part of the Center for Advanced Bioimaging. Contact the group leader to discuss the current project possibilities.

 
Anvendte metoder:Cell/molecular biology, heterologous expression of P2X7 mutants, bioluminescence inflammasome assays, metabolic studies, cell survival and migration assays, 2D and 3D models for pancreatic cancer, advanced live cell imaging techniques
 
Keywords:ATP, cancer, inflammation, imaging, microscopy
 
Projekthjemmeside: https://www1.bio.ku.dk/ansatte/?pure=da/persons/146379
 
Vejleder(e): Professor Ivana Novak, Ph.D. student Lara Magni
 
E-mail:inovak@bio.ku.dk