Acid/base transport and pH homeostasis in pancreatic cancer

Hovedområde:Cell biology
 
Målgruppe:Molecular Biomedicine, Biology, Biochemistry
 
Niveau:Masters, Bachelor
 
Projektbeskrivelse:

Transport of acids and bases over cell membranes is essential for the function of every cell in the body. Some organs maintain body acid/base homeostasis, while others utilize acid/base transport for special purposes, such as digestion, and transport significant quantities of protons and bicarbonates. The exocrine pancreas is the most avid acid/base transporter in our body. However, it is also an organ harboring the most serious disease, the pancreatic cancer.

Our goal is to understand how acid/base transporters and dysregulated pH underlie the pancreatic cancer progression and to target them therapeutically. Our research is carried out in collaboration with our EU partners in the Marie Sklodowska-Curie Innovative Training Networks pHioniC. The student projects available in our lab focus on:

•       Targeting of proton pump and associated potassium channels in pancreatic organoids

•       Interplay between pH sensors and ATP sensor in the tumor microenvironment

•       Mapping of pH landscape in the pancreas

The projects are offered at MSc and BSc level in the above research areas, and we have wide national and international collaborations. We use a wide spectrum of approaches and techniques ranging from the molecular to organismal level. In particular, we are experienced in advanced imaging techniques, and our group runs part of the Center for Advanced Bioimaging. Contact the group leader to discuss the current project possibilities.

 
Anvendte metoder:Advanced organoid models, tissue slice preparations, live cell imaging techniques, cell/molecular biology, heterologous expression, fluorescence, metabolic studies, cell survival and migration assays
 
Keywords:pH, cancer, ATP, imaging, microscopy
 
Projekthjemmeside: https://www1.bio.ku.dk/ansatte/?pure=da/persons/146379
 
Vejleder(e): Professor Ivana Novak, Ph.D. student Ganga Deshar
 
E-mail:inovak@bio.ku.dk