Stine Helene Falsig Pedersen

Stine Helene Falsig Pedersen

Professor

ORCID: 0000-0002-3044-7714

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  1. Published

    Glycosylation of solute carriers: mechanisms and functional consequences

    Pedersen, N. B., Carlsson, M. C. & Pedersen, Stine Helene Falsig, 2016, In: Pflügers Archiv - European Journal of Physiology. 468, 2, p. 159-176 18 p.

    Research output: Contribution to journal › Review › Research › peer-review

  2. Published

    Gram-scale solution-phase synthesis of selective sodium bicarbonate Co-transport Inhibitor S0859: in vitro efficacy studies in breast cancer cells

    Larsen, A. M., Krogsgaard-Larsen, N., Lauritzen, G., Olesen, C. W., Hansen, S. H., Bødtkjer, E., Pedersen, Stine Helene Falsig & Bunch, Lennart, 2012, In: ChemMedChem. 7, 10, p. 1808-1814 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    H-ras transformation sensitizes volume-activated anion channels and increases migratory activity of NIH3T3 fibroblasts.

    Schneider, L., Klausen, T. K., Stock, C., Mally, S., Christensen, Søren Tvorup, Pedersen, Stine Helene Falsig, Hoffmann, E. K. & Schwab, A., 2008, In: Pflügers Archiv: European Journal of Physiology. 455, 6, p. 1055-62 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503

    Gorbatenko, A., Søkilde, R., Sorensen, E. E., Newie, I., Persson, H., Morancho, B., Arribas, J., Litman, Thomas, Rovira, C. & Pedersen, Stine Helene Falsig, 2019, In: Scientific Reports. 9, 1, p. 1-16 3352.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    HL-1 mouse cardiomyocyte injury and death after simulated ischemia and reperfusion: roles of pH, Ca2+-independent phospholipase A2, and Na+/H+ exchange

    Andersen, A., Poulsen, K. A., Lambert, Ian Henry & Pedersen, Stine Helene Falsig, 2009, In: American Journal of Physiology: Cell Physiology. 296, 5, p. C1227-42

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Heat shock protein 70 inhibits shrinkage-induced programmed cell death via mechanisms independent of effects on cell volume-regulatory membrane transport proteins.

    Nylandsted, J., Jäättelä, M., Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2004, In: Pflügers Archiv: European Journal of Physiology. 449, 2, p. 175-85 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression

    Elingaard-Larsen, L. O., Rolver, M. G., Sørensen, E. E. & Pedersen, Stine Helene Falsig, 2022, From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology. Stock, C. & Pardo, L. A. (eds.). Springer, p. 1-38 38 p. (Reviews of Physiology, Biochemistry and Pharmacology, Vol. 182).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  8. Published

    How protons pave the way to aggressive cancers

    Swietach, P., Boedtkjer, E. & Pedersen, Stine Helene Falsig, 2023, In: Nature Reviews Cancer. 23, p. 825-841 17 p.

    Research output: Contribution to journal › Review › Research › peer-review

  9. Published

    Hsp-70 mediated protection of WEHI cells against hypertonic stress-induced programmed cell death by a mechanism independent of effects on volume-regulatory membrane transport proteins

    Pedersen, Stine Helene Falsig, Larsen, J. N., Hoffmann, E. K. & Jaattela, M., 2004, In: The FASEB Journal. 18 (5), p. A1284 suppl.s.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response

    Thirone, A. C. P., Speight, P., Zulys, M., Rotstein, O. D., Szaszi, K., Pedersen, Stine Helene Falsig & Kapus, A., 2009, In: American Journal of Physiology: Cell Physiology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton

    Ly, D. L., Waheed, F., Lodyga, M., Speight, P., Masszi, A., Nakano, H., Hersom, M. N. S., Pedersen, Stine Helene Falsig, Szászi, K. & Kapus, A., 2013, In: American Journal of Physiology: Cell Physiology. 304, 2, p. C115-C127 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Hyperosmotic stress strongly potentiates serum response factor (SRF)-dependent transcriptional activity in ehrlich lettré ascites cells through a mechanism involving p38 mitogen-activated protein kinase

    Gorbatenko, A., Wiwel, M., Klingberg, H., Nielsen, A. B., Kapus, A. & Pedersen, Stine Helene Falsig, 2011, In: Journal of Cellular Physiology. 226, 11, p. 2857-2868 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Increases in [Ca2+]i and changes in intracellular pH during chemical anoxia in mouse neocortical neurons in primary culture.

    Jørgensen, N. K., Pedersen, Stine Helene Falsig, Damgaard, I., Schousboe, A. & Hoffmann, E. K., 1999, In: Journal of Neuroscience Research. 56, p. 358-370

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Induction of group VIA phospholipase A2 activity during in vitro ischemia in C2C12 myotubes is associated with changes in the level of its splice variants.

    Poulsen, K. A., Pedersen, Stine Helene Falsig, Kolko, M. & Lambert, Ian Henry, 2007, In: American Journal of Physiology: Cell Physiology. 293, 5, p. C1605-15

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment

    Andersen, Anne Poder, Moreira, José & Pedersen, Stine Helene Falsig, 2014, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1638, 11 p., 20130098.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Intracellular pH gradients in migrating cells

    Martin, C., Pedersen, Stine Helene Falsig, Schwab, A. & Stock, C., 2011, In: American Journal of Physiology: Cell Physiology. 300, 3, p. C490-C495 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes

    Haxholm, G. W., Nikolajsen, L. F., Olsen, Johan Gotthardt, Fredsted, J., Larsen, F. H., Goffin, V., Pedersen, Stine Helene Falsig, Brooks, A. J., Waters, M. J. & Kragelund, Birthe Brandt, 2015, In: Biochemical Journal. 468, 3, p. 495-506 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration

    Veland, I. R., Montjean, R., Eley, L., Pedersen, Lotte Bang, Schwab, A., Goodship, J., Kristiansen, Karsten, Pedersen, Stine Helene Falsig, Saunier, S. & Christensen, Søren Tvorup, 2013, In: P L o S One. 8, 4, 15 p., e60193.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Ion channels and transporters in cancer: pathophysiology, regulation, and clinical potential

    Pedersen, Stine Helene Falsig & Stock, C., 2013, In: Cancer Research. 73, 6, p. 1658-1661 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Ion transport proteins control pancreatic cancer cell behaviour

    Schwab, A., Stock, C., Swietach, P., Hulikova, A., Vaughan-Jones, R. D., Pedersen, S. H. F., Andersen, A-D., Hoffmann, E. K., Novak, I., Reshkin, S., Prevarskaya, N., Lemonnier, L., Borowiec, A. S., Arcangeli, A., Zanieri, F., D´Amico, M., Fraser, S. P., Djamgoz, M. BA., Alves, F., Kalthoff, H. & 2 others, Pardo, L. A. & Stühmer, W., 2010, In: Acta Physiologica (Print Edition). 198, 677, p. 17 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  21. Published

    Ion transport proteins control pancreatic ductal adenocarcinoma

    Schwab, A., Stock, C., Swietach, P., Hulikova, A., Vaughan-Jones, R., Pedersen, S. H. F., Andersen, A. D., Hoffmann, E., Novak, I., Reshkin, S., Prevarskaya, N., Lemonnier, L., A-S, B., Fraser, S. P., Arcangeli, A., Zanieri, F., D'Amico, M., Kalthoff, H., Djamgoz, M. B., Alves, F. & 2 others, Pardo, L. & Stuehmer, W., 1 Oct 2010, In: Onkologie. 33, Suppl. 6, p. 269 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4

    Jørgensen, Kathrine Lundø, Dmytriyeva, O., Spøhr, L., Alves, Eliana Carolina Goncalves, Yao, Jiayi, Puig Blasco, Laia, Trauelsen, Mette, Ponniah, M., Severin, M., Sandelin, Albin Gustav, Kveiborg, Marie, Schwartz, Thue W. & Pedersen, Stine Helene Falsig, 2023, In: BMC Cancer. 23, 1, 20 p., 1136.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair

    Schreml, S., Meier, R. J., Kirschbaum, M., Kong, S. C., Gehmert, S., Felthaus, O., Kuechler, S., Sharpe, J. R., Woeltje, K., Weiss, K. T., Albert, M., Seidl, U., Schroeder, J., Morsczeck, C., Prantl, L., Duschl, C., Pedersen, S. H. F., Gosau, M., Berneburg, M., Wolfbeis, O. S. & 2 others, Landthaler, M. & Babilas, P., 2014, In: Theranostics. 4, 7, p. 721-735 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    MCT1 and MCT4 expression and lactate flux activity increase during white and brown adipogenesis and impact adipocyte metabolism

    Petersen, C., Nielsen, M. D., Andersen, E. S., Basse, A. L., Isidor, Marie Sophie, Markussen, L. K., Viuff, B. M., Lambert, Ian Henry, Hansen, Jacob B. & Pedersen, Stine Helene Falsig, 12 Oct 2017, In: Scientific Reports. 7, 1, 13 p., 13101.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells

    Meng, Signe, Sørensen, E. E., Ponniah, M., Thorlacius-Ussing, J., Crouigneau, R., Larsen, T., Borre, M. T., Willumsen, N., Flinck, M. & Pedersen, Stine Helene Falsig, 2024, In: Journal of Cell Science. 137, 8, 15 p., jcs261608.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Mechanical stress induces release of ATP from Ehrlich ascites tumor cells.

    Pedersen, S., Pedersen, Stine Helene Falsig, Nilius, B., Lambert, Ian Henry & Hoffmann, E. K., 1999, In: BBA General Subjects. 1416, p. 271-284

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells.

    Pedersen, Stine Helene Falsig, Varming, C., Christensen, Søren Tvorup & Hoffmann, E. K., 2002, In: Journal of Membrane Biology. 189, 1, p. 67-81 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Mechanisms of pHi regulation studied in individual neurons cultured from mouse cerebral cortex

    Pedersen, Stine Helene Falsig, Jørgensen, N. K., Damgaard, I., Schousboe, A. & Hoffmann, E. K., 1998, In: Journal of Neuroscience Research. 51, p. 431-441

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets

    Andersen, Henriette Berg, Ialchina, Renata, Pedersen, Stine Helene Falsig & Czaplinska, D., 2021, In: Cancer and Metastasis Reviews. 40, 4, p. 1093-1114 22 p.

    Research output: Contribution to journal › Review › Research › peer-review

  30. Published

    Metabolism and microenvironment in cancer plasticity

    Baldini, N., Sonveaux, P., De Milito, A., Supuran, C. T., Otto, A. M., Stock, C. M., Pedersen, Stine Helene Falsig, Favicchio, R. & Avnet, S., 2016, In: Cancer & Metabolism. 4, Supplement 1, 7 p., 1.

    Research output: Contribution to journal › Comment/debate › Research

  31. Published

    Modeling the ischemic blood-brain barrier; the effects of oxygen-glucose deprivation (OGD) on endothelial cells in culture

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig, Waagepetersen, Helle S. & Larsen, Birger Brodin, 19 Jun 2016.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  32. Published

    Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study

    Klausen, T. K., Pagani, A., Minassi, A., Ech-Chahad, A., Prenen, J., Owsianik, G., Hoffmann, E. K., Pedersen, Stine Helene Falsig, Appendino, G. & Nilius, B., 2009, In: Journal of Medicinal Chemistry. 52, 9, p. 2933-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin

    Hendus-Altenburger, R., Wang, X., Sjøgaard-Frich, Lise Margrethe, Pedraz Cuesta, E., Sheftic, S. R., Bendsøe, A. H., Page, R., Kragelund, Birthe Brandt, Pedersen, Stine Helene Falsig & Peti, W., 2019, In: Nature Communications. 10, 13 p., 3489.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Molecular cloning of NHE1 from Winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A

    Pedersen, Stine Helene Falsig, King, S. A., Rigor, R. R., Zhuang, Z., Warren, J. M. & Cala, P. M., 2003, In: FASEB Journal. Vol. 19 (4), p. A 139- A 140

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Molecular cloning of NHE1 from Winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A.

    Pedersen, Stine Helene Falsig, King, S. A., Rigor, R. R., Zhuang, Z., Warren, J. M. & Cala, P. M., 2003, In: American Journal of Physiology.. Vol. 284 (6), p. C1561-C1576

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Monocarboxylate transporters MCT1 and MCT4 regulate migration and invasion of pancreatic ductal adenocarcinoma cells

    Kong, S. C., Nøhr-Nielsen, A., Zeeberg, K., Reshkin, S. J., Hoffmann, E. K., Novak, Ivana & Pedersen, Stine Helene Falsig, 2016, In: Pancreas. 45, 7, p. 1036-1047 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Monovalent ions control proliferation of Ehrlich Lettre ascites cells

    Klausen, T. K., Preisler, S., Pedersen, Stine Helene Falsig & Hoffmann, E. K., 1 Sep 2010, In: American Journal of Physiology (Consolidated). 299, 3, p. C714-25

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Multiple PLA2 isoforms regulate taurine release in NIH3T3 mouse fibroblasts.

    Lambert, Ian Henry & Pedersen, Stine Helene Falsig, 2006, In: Advances in Experimental Medicine and Biology. 583, p. 99-108 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Myocardin-related transcription factor regulates Nox4 protein expression: linking cytoskeletal orginization to redox state

    Rozycki, M., Bialik, J. F., Speight, P., Dan, Q., Knudsen, Teresa Emmilie Toudal, Szeto, S. G., Yuen, D. A., Szászi, K., Pedersen, Stine Helene Falsig & Kapus, A., 2016, In: Journal of Biological Chemistry. 291, 1, p. 227-243 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance

    Lauritzen, G., Jensen, M. B. F., Bødtkjer, E., Dybboe, R., Aalkjær, Christian, Nylandsted, J. & Pedersen, Stine Helene Falsig, 10 Sep 2010, In: Experimental Cell Research. 316, 15, p. 2538-53 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity.

    Pedersen, Stine Helene Falsig, King, S. A., Nygaard, E. B., Rigor, R. R. & Cala, P. M., 2007, In: Journal of Biological Chemistry. 282, 27, p. 19716-27 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Na+,HCO3--cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice

    Lee, S., Axelsen, T. V., Jesse, N., Pedersen, Stine Helene Falsig, Vahl, P. & Boedtkjer, E., 2018, In: Oncogene. 37, 41, p. 5569-5584

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    O-glycan initiation directs distinct biological pathways and controls epithelial differentiation

    Bagdonaite, Ieva , Pallesen, E. M. H., Ye, Z., Vakhrushev, Sergey, Marinova, I. N., Nielsen, Mathias Alexander Ingemann, Kramer, S. H., Pedersen, Stine Helene Falsig, Joshi, Hiren Jitendra, Bennett, Eric Paul, Dabelsteen, Sally & Wandall, Hans H., 2020, In: EMBO Reports. 21, 6, 17 p., e48885.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    On the role of TRPC1 in control of Ca2+ influx, cell volume, and cell cycle

    Madsen, C. P., Klausen, T. K., Fabian, A., Hansen, B. J., Pedersen, Stine Helene Falsig & Hoffmann, E. K., 2012, In: American Journal of Physiology: Cell Physiology. 303, 6, p. C625-C634 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Oncogenic p95HER2 regulates Na+-HCO3- cotransporter NBCn1 mRNA stability in breast cancer cells via 3'UTR-dependent processes

    Gorbatenko, A., Olesen, C. W., Loebl, N., Sigurdsson, H. H., Bianchi, C., Pedraz Cuesta, E., Christiansen, Jan & Pedersen, Stine Helene Falsig, 2016, In: Biochemical Journal. 473, 21, p. 4027-4044 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Osmosensory mechanisms in cellular and systemic volume regulation

    Pedersen, Stine Helene Falsig, Kapus, A. & Hoffmann, E. K., 2011, In: Journal of the American Society of Nephrology. 22, 9, p. 1587-97 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications

    Rasmussen, M., Alexander, R. T., Darborg, B. V., Møbjerg, Nadja, Hoffmann, E. K., Kapus , A. & Pedersen, Stine Helene Falsig, 2008, In: American Journal of Physiology: Cell Physiology. 294, 1, p. C197-C212 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells

    Rasmussen, L. J. H., Mûller, H. S. H., Jørgensen, B., Pedersen, Stine Helene Falsig & Hoffmann, E. K., 2015, In: American Journal of Physiology: Cell Physiology. 308, 2, p. C101-C110 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    P2 receptor-mediated signal transduction in Ehrlich ascites tumor cells

    Pedersen, Stine Helene Falsig, Pedersen, S., Lambert, Ian Henry & Hoffmann, E. K., 1998, In: BBA General Subjects. 1374, p. 94-106

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    PDGFR alpha signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90(RSK) and AKT signaling pathways

    Clement, Ditte Lynge, Mally, S., Stock, C., Lethan, M., Satir, P., Schwab, A., Pedersen, Stine Helene Falsig & Christensen, Søren Tvorup, 2013, In: Journal of Cell Science. 126, 4, p. 953-965 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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