Per Amstrup Pedersen
Associate Professor
Cell Biology and Physiology
Universitetsparken 13
2100 København Ø
- 2024
- Published
Imaging of extracellular and intracellular ATP in pancreatic beta cells reveals correlation between glucose metabolism and purinergic signalling
Ghiasi, S. M., Christensen, Nynne, Pedersen, Per Amstrup, Skovhøj, Emil Zeng & Novak, Ivana, 2024, In: Cellular Signalling. 117, 12 p., 111109.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases
Guo, Zongxin, Orädd, F., Bågenholm, Viktoria, Grønberg, C., Ma, J. F., Ott, P., Wang, Y., Andersson, M., Pedersen, Per Amstrup, Wang, Kaituo & Gourdon, Pontus Emanuel, 2024, In: Nature Communications. 15, 1, 16 p., 2690.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
pXOOY: A dual-function vector for expression of membrane proteins in Saccharomyces cerevisiae and Xenopus laevis oocytes
Vold, Victoria Amstrup, Glanville, S., Klærke, Dan Arne & Pedersen, Per Amstrup, 2023, In: PLoS ONE. 18, 2, 16 p., e0281868.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5
Merklinger, L., Bauer, J., Pedersen, Per Amstrup, Damgaard, R. B. & Morth, J. P., 2022, In: Life Science Alliance. 5, 8, 13 p., e202101309.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of water coordination in the pH-dependent gating of hAQP10
Truelsen, S. F., Missel, Julie Winkel, Gotfryd, K., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel, Lindorff-Larsen, Kresten & Hélix-Nielsen, C., 2022, In: B B A - Biomembranes. 1864, 1, 13 p., 183809.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Production of an Active, Human Membrane Protein in Saccharomyces cerevisiae: Full-Length FICD
Virolainen, M. S., Søltoft, C. L., Pedersen, Per Amstrup & Ellgaard, Lars, 2022, In: International Journal of Molecular Sciences. 23, 5, 17 p., 2458.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Isolation and Crystallization of the D156C Form of Optogenetic ChR2
Zhang, L., Wang, Kaituo, Ning, S., Pedersen, Per Amstrup, Duelli, A. S. & Gourdon, Pontus Emanuel, 2022, In: Cells. 11, 5, 11 p., 895.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Overproduction of Human Zip (SLC39) Zinc Transporters in Saccharomyces cerevisiae for Biophysical Characterization
Becares, E. R., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel & Gotfryd, K., 2021, In: Cells. 10, 2, 21 p., 213.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Order and disorder - An integrative structure of the full-length human growth hormone receptor
Kassem, N., Araya-Secchi, R., Bugge, K., Barclay, A., Steinocher, H., Khondker, A., Wang, Y., Lenard, A. J., Bürck, J., Sahin, Cagla, Ulrich, A. S., Landreh, M., Pedersen, Martin Cramer, Rheinstädter, M. C., Pedersen, Per Amstrup, Lindorff-Larsen, Kresten, Arleth, Lise & Kragelund, Birthe Brandt, 2021, In: Science Advances. 7, 27, 20 p., eabh3805.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Occipital Horn Syndrome as a Result of Splice Site Mutations in ATP7A. No Activity of ATP7A Splice Variants Missing Exon 10 or Exon 15
Møller, L. B., Mogensen, M., Weaver, D. D. & Pedersen, Per Amstrup, 2021, In: Frontiers in Molecular Neuroscience. 14, 12 p., 532291.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations
Pimpão, C., Wragg, D., Bonsignore, R., Aikman, B., Pedersen, Per Amstrup, Leoni, S., Soveral, G. & Casini, A., 2021, In: Metallomics. 13, 9, 11 p., mfab053.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Saccharomyces cerevisiae as a superior host for overproduction of prokaryotic integral membrane proteins
Preisler, Sarah Spruce, Wiuf, A. D., Friis, M., Kjaergaard, L., Hurd, M., Becares, E. R., Nurup, C. N., Bjoerkskov, F. B., Szathmáry, Z., Gourdon, Pontus Emanuel, Callø, Kirstine, Klærke, Dan Arne, Gotfryd, K. & Pedersen, Per Amstrup, 2021, In: Current research in structural biology. 3, p. 51-71 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recombinant production of membrane proteins in yeast
Preisler, Sarah Spruce, Hansen, K. M., Nurup, C. N., Beich-Frandsen, M. & Pedersen, Per Amstrup, 2021, Methods in Enzymology. Pyle, A. M. & Christianson, D. W. (eds.). Academic Press, Vol. 660. p. 21-52 32 p. (Methods in Enzymology, Vol. 660).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2020
- Published
The rapid “teabag” method for high-end purification of membrane proteins
Hering, J., Missel, Julie Winkel, Zhang, L., Gunnarsson, A., Castaldo, M., Pedersen, Per Amstrup, Ek, M., Gourdon, Pontus Emanuel & Snijder, H. J., 2020, In: Scientific Reports. 10, 11 p., 16167.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Yeast recombinant production of intact human membrane proteins with long intrinsically disordered intracellular regions for structural studies
Kassem, N., Kassem, M. M., Pedersen, Stine Helene Falsig, Pedersen, Per Amstrup & Kragelund, Birthe Brandt, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 14 p., 183272.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Purification and initial characterization of Plasmodium falciparum K+ channels, PfKch1 and PfKch2 produced in Saccharomyces cerevisiae
Molbaek, K., Tejada, M., Ricke, C. H., Scharff-Poulsen, P., Ellekvist, P., Helix-Nielsen, C., Kumar, N., Klærke, Dan Arne & Pedersen, Per Amstrup, 2020, In: Microbial Cell Factories. 19, 1, 183.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Characterization of Hailey-Hailey Disease-mutants in presence and absence of wild type SPCA1 using Saccharomyces cerevisiae as model organism
Muncanovic, D., Justesen, M. H., Preisler, Sarah Spruce & Pedersen, Per Amstrup, 2019, In: Scientific Reports. 9, 25 p., 12442.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human aquaporin-5 facilitates hydrogen peroxide permeation affecting adaption to oxidative stress and cancer cell migration
Rodrigues, C., Pimpão, C., Mósca, A. F., Coxixo, A. S., Lopes, D., Da Silva, I. V., Pedersen, Per Amstrup, Antunes, F. & Soveral, G., 2019, In: Cancers. 11, 7, 17 p., 932.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of the human ClC-1 chloride channel
Wang, Kaituo, Preisler, Sarah Spruce, Zhang, L., Cui, Y., Missel, Julie Winkel, Grønberg, C., Gotfryd, K., Lindahl, E., Andersson, M., Callø, Kirstine, Egea, P. F., Klærke, Dan Arne, Pusch, M., Pedersen, Per Amstrup, Zhou, Z. H. & Gourdon, Pontus Emanuel, 2019, In: PLOS Biology. 17, 4, p. 1-20 e3000218.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Purification of Functional Human TRP Channels Recombinantly Produced in Yeast
Zhang, L., Wang, Kaituo, Klærke, Dan Arne, Callø, Kirstine, Lowrey, L., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel & Gotfryd, K., 2019, In: Cells. 8, 2, p. 1-20 148.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Human adipose glycerol flux is regulated by a pH gate in AQP10
Gotfryd, K., Mósca, A. F., Missel, Julie Winkel, Truelsen, S. F., Wang, Kaituo, Spulber, M., Krabbe, S., Hélix-nielsen, C., Laforenza, U., Soveral, G., Pedersen, Per Amstrup & Gourdon, Pontus Emanuel, 2018, In: Nature Communications. 9, p. 1-11 4749.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reconstitution and Electrophysiological Characterization of Ion Channels in Lipid Bilayers
Klærke, Dan Arne, Tejada, M. D. L. A., Christensen, V. G., Lassen, M., Pedersen, Per Amstrup & Callø, Kirstine, 2018, In: Current Protocols in Pharmacology. 81, 1, p. e37 17 p., e37.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
From channel proteins to industrial biomimetic membrane technology
Pedersen, Per Amstrup, Bjørkskov, F. B., Alvisse, S. & Hélix-Nielsen, C., 2018, In: Faraday Discussions. 209, p. 287-301 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human AQP5 facilitates hydrogen peroxide permeation and improves cell resistance to oxidative stress
Rodrigues, C., Mósca, A. F., Lopes, D., Pedersen, Per Amstrup, Antunes, F. & Soveral, G., 2018, In: Free Radical Biology and Medicine. 120, Suppl. 1, p. S70 P-86.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- 2017
- Published
Purification and functional comparison of nine human Aquaporins produced in Saccharomyces cerevisiae for the purpose of biophysical characterization
Bjørkskov, F. B., Krabbe, S., Nurup, C. N., Missel, Julie Winkel, Spulber, M., Bomholt, J., Molbaek, K., Helix-Nielsen, C., Gotfryd, K., Gourdon, Pontus Emanuel & Pedersen, Per Amstrup, 4 Dec 2017, In: Scientific Reports. 7, 21 p., 16899.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease
Skjørringe, T., Pedersen, Per Amstrup, Thorborg, S. S., Nissen, P., Gourdon, Pontus Emanuel & Møller, L. B., 7 Apr 2017, In: Scientific Reports. 7, 18 p., 757.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Single-Channel Recordings of K+ Channels Expressed in Saccharomyces Cerevisiae
Tejada, M. D. L. A., Molbaek, K., Cazimi, H., Ellekvist, P., Callø, Kirstine, Nielsen, C. H., Pedersen, Per Amstrup & Klærke, Dan Arne, 2017, In: Biophysical Journal. 112, 3, Suppl. 1, p. 406A 1 p., 2002-Pos Board B322.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- 2015
- Published
High yield purification of full-length functional hERG K+ channels produced in Saccharomyces cerevisiae
Hansen, K. M., Scharff-Poulsen, P., Hélix-Nielsen, C., Klærke, Dan Arne & Pedersen, Per Amstrup, 2015, In: Microbial Cell Factories. 14, 16 p., 15.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle
Biensø, R. S., Knudsen, Jakob Grunnet, Brandt, N., Pedersen, Per Amstrup & Pilegaard, Henriette, 2014, In: Pflügers Archiv - European Journal of Physiology. 466, 8, p. 1647-1657 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of vesicular nucleotide transporter VNUT (SLC17A9) in release of ATP from AR42J cells and mouse pancreatic acinar cells
Haanes, Kristian Agmund, Kowal, J. M., Arpino, G., Lange, S. C., Moriyama, Y., Pedersen, Per Amstrup & Novak, Ivana, 2014, In: Purinergic Signalling. 10, 3, p. 431-440 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
mTOR ensures increased release and reduced uptake of the organic osmolyte taurine under hypoosmotic conditions in mouse fibroblasts
Lambert, Ian Henry, Jensen, J. V. & Pedersen, Per Amstrup, 2014, In: American Journal of Physiology: Cell Physiology. 306, 11, p. C1028-C1040 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Recombinant Production of Human Aquaporin-1 to an Exceptional High Membrane Density in Saccharomyces cerevisiae
Bomholt, J., Hélix-Nielsen, C., Scharff-Poulsen, P. & Pedersen, Per Amstrup, 2013, In: P L o S One. 8, 2, 9 p., e56431.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo studies of aquaporins 3 and 10 in human stratum corneum
Jungersted, J., Bomholt, J., Bajraktari, N., Hansen, J. S., Klærke, Dan Arne, Pedersen, Per Amstrup, Hedfalk, K., Nielsen, K. H., Agner, T. & Hélix-Nielsen, C., 2013, In: Archives of Dermatological Research. 305, 8, p. 699-704 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Saccharomyces cerevisiae-based platform for rapid production and evaluation of Eukaryotic Nutrient transporters and transceptors for biochemical studies and crystallography
Scharff-Poulsen, P. & Pedersen, Per Amstrup, 2013, In: PLoS ONE. 8, 10, 12 p., e76851.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Role of PGC-1{alpha} in exercise and fasting induced adaptations in mouse liver
Haase, T. N., Jørgensen, S. R., Leick, L., Biensø, R. S., Kiilerich, K., Johansen, S., Nielsen, M. M., Wojtaszewski, Jørgen F P, Hidalgo, J., Pedersen, Per Amstrup & Pilegaard, Henriette, 2011, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 301, 5, p. R1501-R1509 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle
Kiilerich, K., Gudmundsson, M., Birk, Jesper Bratz, Lundby, C., Taudorf, S., Plomgaard, Peter Stendahl, Saltin, B., Pedersen, Per Amstrup, Wojtaszewski, Jørgen F P & Pilegaard, Henriette, 2010, In: Diabetes. 59, 1, p. 26-32 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PGC-1{alpha} increases PDH content but does not change acute PDH regulation in mouse skeletal muscle
Kiilerich, K., Adser, H., Jakobsen, A. H., Pedersen, Per Amstrup, Hardie, D. G., Wojtaszewski, Jørgen F P & Pilegaard, Henriette, 2010, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 299, 5, p. R1350-R1359 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Heterologous Expression of Membrane and Soluble Proteins Derepresses GCN4 mRNA Translation in the Yeast Saccharomyces cerevisiae
Steffensen, L. & Pedersen, Per Amstrup, 2006, In: Eukaryotic Cell. 5, 2, p. 248-261Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Oprensning af sjældent forekommende membranproteiner
Pedersen, Per Amstrup, 2005, Proteiner: oprensning og karakterisering. Kielberg, V. & Rasmussen, L. (eds.). 3. ed. København: Gyldendal, p. 67-76Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Rekombinant fremstillede proteiner
Pedersen, Per Amstrup, 2005, Proteiner: oprensning og karakterisering. Kielberg, V. & Rasmussen, L. (eds.). 3. ed. København: Gyldendal, p. 77-86Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs
Teilmann, S. C., Byskov, A. G., Pedersen, Per Amstrup, Wheatley, D. N., Pazour, G. J. & Christensen, Søren Tvorup, 2005, In: Molecular Reproduction and Development. 71, 4, p. 444-452Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Identification and partial characterization of Taastrup virus: a newly identified member species of the Monomegavirales
Bock, J. O., Lundsgaard, T., Pedersen, Per Amstrup & Christensen, L. S., 2004, In: Virology. 319, p. 49-59Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Overexpression of SERCA1a Ca2+-ATPase in Yeast
Falson, P., Lenoir, G., Menguy, T., Corre, F., Montigny, C., Pedersen, Per Amstrup, Thinès, D. & le Maire, M., 2003, In: Ann. N. Y. Acad. Sci.. 986, p. 312-314Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cloning, expression, purification and crystallization of the N-domain from the alpha(2) subunit of the membrane-spanning Na,K-ATPase protein
Haue, L., Pedersen, Per Amstrup, Jorgensen, P. L. & Håkansson, K. O., Jul 2003, In: Acta crystallographica Section D: Structural biology . 59, Pt 7, p. 1259-61 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cloning and characterisation of a glucoamylase gene (GlaM) from dimorphic zygomycete Mucor circinelloides
Houghton-Larsen, J. & Pedersen, Per Amstrup, 2003, In: Applied Microbiology and Biotechnology. 62, 2-3, p. 210-217Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional expression of rat adenosine A1 receptor in the dimorphic zygomycete Mucor circinelloides
Houghton-Larsen, J. & Pedersen, Per Amstrup, 2003, In: Appl. Microbiol. Biotechnol.. 63, p. 64-67Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amino Acids in the TM4-TM5 loop of Na,K-ATPase Are Important for Biosynthesis
Jørgensen, J. R., Houghton-Larsen, J., Jacobsen, M. D. & Pedersen, Per Amstrup, 2003, In: Annals of the New York Academy of Sciences. 986, p. 369-377Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Responses at the Translational Level to Heterologous Expression of the Na,K-ATPase
Steffensen, L. & Pedersen, Per Amstrup, 2003, In: Annals of the New York Academy of Sciences. 986, p. 539-540Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Importance of Na,K-ATPase Residueβ-1Arg544 in the Segment Arg544-ASP567 for High-Affinity Binding of ATP, ADP, or MgATP
Jacobsen, M. D., Pedersen, Per Amstrup & Jorgensen, P. L., 2002, In: Biochemistry. 41, p. 1451-1456Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Overproduction in yeast and rapid and efficient purification of the rabbit SERCA1a Ca2+-ATPase
Lenoir, G., Menguy, T., Corre, F., Montigny, C., Pedersen, Per Amstrup, Thinès, D., le Maire, M. & Falson, P., 2002, In: BBA General Subjects. 1560, p. 67-83Research output: Contribution to journal › Journal article › Research › peer-review
ID: 12553
Most downloads
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1155
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Recombinant Production of Human Aquaporin-1 to an Exceptional High Membrane Density in Saccharomyces cerevisiae
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
957
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Saccharomyces cerevisiae-based platform for rapid production and evaluation of Eukaryotic Nutrient transporters and transceptors for biochemical studies and crystallography
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
925
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Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle
Research output: Contribution to journal › Journal article › Research › peer-review
Published