Søren Tvorup Christensen
Professor
Cell Biology and Physiology
Universitetsparken 13
2100 København Ø
- 2024
- Published
DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2
Rezi, C. K., G. Aslanyan, M., D. Diwan, G., Cheng, T., Chamlali, M., Junger, K., Anvarian, Z., Lorentzen, E., Pauly, K., Afshar-Bahadori, Y., FA Fernandes, E., Qian, F., Tosi, S., Christensen, S. T., Pedersen, S. H. F., Strømgaard, K., B. Russell, R., H. Miner, J., R. Mahjoub, M., Boldt, K. & 2 others, , 7 Jun 2024, In: E M B O Reports.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Cilia and flagella
Pedersen, Lotte Bang, Jurisch-Yaksi, N., Schmid, F. M. & Christensen, Søren Tvorup, 2023, Encyclopedia of Cell Biology, Second Edition. Bradshaw, R. A., Hart, G. W. & Stahl, P. D. (eds.). 2 ed. Oxford: Elsevier, Vol. 3. p. 164-188 25 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Editorial: Signaling by primary cilia in development and disease
Kim, S. E., Nechipurenko, I. & Christensen, Søren Tvorup, 2023, In: Frontiers in Cell and Developmental Biology. 11, 3 p., 1186367.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Expression of genes and enzymes involved in ovarian steroidogenesis in relation to human follicular development
Zheng, M., tcg964, tcg964, Rasmussen, F. R., Cadenas, J., Christensen, Søren Tvorup & Mamsen, L. S., 2023, In: Frontiers in Endocrinology. 14, 17 p., 1268248.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Primary cilia as dynamic and diverse signalling hubs in development and disease
Mill, P., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2023, In: Nature Reviews. Genetics. 24, 21 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The genetic background of hydrocephalus in a population-based cohort: implication of ciliary involvement
Munch, Tina Nørgaard, Hedley, P. L., Hagen, C. M., Baekvad-Hansen, M., Geller, F., Bybjerg-Grauholm, J., Nordentoft, Merete, Borglum, A. D., Werge, Thomas, Melbye, M., Hougaard, D. M., Larsen, Lars Allan, Christensen, Søren Tvorup & Christiansen, M., 2023, In: Brain Communications. 5, 1, 14 p., fcad004.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling
Morthorst, Stine Kjær, Nielsen, C., Farinelli, P., Anvarian, Zeinab, Rasmussen, C. B. R., Serra-Marques, A., Grigoriev, I., Altelaar, M., Fürstenberg, N., Ludwig, A., Akhmanova, A., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2022, In: Journal of Cell Science. 135, 12, 10 p., jcs259471.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peter Satir (1936-2022), cell biology pioneer and mentor
Sale, W. S. & Christensen, Søren Tvorup, 2022, In: Journal of Cell Science. 135, 23Research output: Contribution to journal › Comment/debate › Research
- Published
Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models
Christensen, S. L., Rasmussen, Rikke Holm, Cour, S. L., Ernstsen, C., Hansen, Thomas Folkmann, Kogelman, L. J. A., Lauritzen, S. P., Guzaite, G., Styrishave, Bjarne, Janfelt, Christian, Christensen, Søren Tvorup, Aziz, Q., Tinker, A., Jansen-Olesen, I., Olesen, Jes & Kristensen, D. M., 2022, In: Cephalalgia. 42, 2, p. 93-107Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
ALMS1 Regulates TGF-β Signaling and Morphology of Primary Cilia
Álvarez-Satta, M., Lago-Docampo, M., Bea-Mascato, B., Solarat, C., Castro-Sánchez, S., Christensen, Søren Tvorup & Valverde, D., 2021, In: Frontiers in Cell and Developmental Biology. 9, 8 p., 623829.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels
Gonçalves, A. B., Hasselbalch, S. K., Joensen, B. B., Patzke, S., Martens, P., Ohlsen, S. K., Quinodoz, M., Nikopoulos, K., Suleiman, R., Jeppesen, M. P. D., Weiss, C., Christensen, Søren Tvorup, Rivolta, C., Andersen, J. S., Farinelli, P. & Pedersen, Lotte Bang, 2021, In: eLife. 10, 34 p., e63731.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine
Christensen, S. L., Rasmussen, R. H., Ernstsen, C., La Cour, S., David, A., Chaker, J., Haanes, K. A., Christensen, Søren Tvorup, Olesen, Jes & Kristensen, D. M., 2021, In: Cephalalgia. 41, 14, p. 1413-1426 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-acetylcysteine protects ovarian follicles from ischemia-reperfusion injury in xenotransplanted human ovarian tissue
Olesen, H. Ø., Pors, S. E., Jensen, L. B., Grønning, A. P., Lemser, C. E., Heimbürger, M. T. H. N., Mamsen, L. S., Getreu, N., Christensen, Søren Tvorup, tcg964, tcg964 & Kristensen, S. G., 2021, In: Human Reproduction. 36, 2, p. 429-443 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Ciliary Localization of the Intraflagellar Transport Protein IFT88 Is Disrupted in Cystic Fibrosis
Stevens, E. M., Vladar, E. K., Alanin, M. C., Christensen, Søren Tvorup, von Buchwald, Christian & Milla, C., Jan 2020, In: American Journal of Respiratory Cell and Molecular Biology. 62, 1, p. 120-123 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analysis of caveolin in primary cilia
Morthorst, Stine Kjær, Mogensen, J. B., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2020, Caveolae: Methods and Protocols. Blouin, C. M. (ed.). Humana Press, p. 27-41 (Methods in Molecular Biology, Vol. 2169).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution
Björkman, A., Johansen, S. L., Lin, L., Schertzer, M., Kanellis, D. C., Katsori, A., Christensen, Søren Tvorup, Luo, Y., Andersen, J. S., Elsässer, S. J., Londono-Vallejo, A., Bartek, J. & Schou, K. B., 2020, In: Genes & Development. 34, 15-16, p. 1065-1074 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis
Farooq, M., Lindbæk, L., Krogh, N., Doganli, C., Keller, C., Mönnich, M., Gonçalves, A. B., Sakthivel, S., Mang, Y., Fatima, A., Andersen, V. S., Hussain, M. S., Eiberg, H., Hansen, L., Kjaer, K. W., Gopalakrishnan, J., Pedersen, L. B., Møllgård, K., Nielsen, H., Baig, S. M. & 3 others, , 2020, In: Nature Communications. 11, 16 p., 5816.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TGFβ Signaling Increases Net Acid Extrusion, Proliferation and Invasion in Panc-1 Pancreatic Cancer Cells: SMAD4 Dependence and Link to Merlin/NF2 Signaling
Malinda, R. R., Zeeberg, K., Sharku, P. C., Ludwig, M. Q., Pedersen, Lotte Bang, Christensen, Søren Tvorup & Pedersen, Stine Helene Falsig, 2020, In: Frontiers in Oncology. 10, 15 p., 687.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Cellular signalling by primary cilia in development, organ function and disease
Anvarian, Zeinab, Mykytyn, K., Mukhopadhyay, S., Pedersen, Lotte Bang & Christensen, Søren Tvorup, 2019, In: Nature Reviews Nephrology. 15, p. 199-219Research output: Contribution to journal › Review › Research › peer-review
- Published
Comparison of cultured human cardiomyocyte clusters obtained from embryos/fetuses or derived from human embryonic stem cells
Grubb, Søren, Vestergaard, M. L., Andersen, A. S., Rasmussen, K. K., Mamsen, L., Tuckute, G., Grunnet-Lauridsen, K., Møllgård, Kjeld, Ernst, E., Christensen, Søren Tvorup, Callø, Kirstine & tcg964, tcg964, 2019, In: Stem Cells and Development. 28, 9, p. 608-619Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium
Mönnich, M., Borgeskov, L., Breslin, L., Jakobsen, L., Rogowski, M., Doganli, Canan, Schrøder, J. M., Mogensen, J. B., Blinkenkjær, L., Harder, L. M., Lundberg, E., Geimer, S., Christensen, Søren Tvorup, Andersen, J. S., Larsen, Lars Allan & Pedersen, Lotte Bang, 2018, In: Cell Reports. 22, 10, p. 2584-2592 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Challenges for the sustainability of university-run biobanks
Kongsholm, Nana Cecilie Halmsted, Christensen, Søren Tvorup, Herrmann, Janne Rothmar, Larsen, Lars Allan, Minssen, Timo, Pedersen, Lotte Bang, Rajam, N., Tommerup, Niels, Tupasela, A. M. & Schovsbo, Jens Hemmingsen, 2018, In: Biopreservation and Biobanking. 16, 4, p. 312-321 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases
Schmid, F. M., Schou, K. B., Vilhelm, M. J., Holm, M. S., Breslin, L., Farinelli, P., Larsen, Lars Allan, Andersen, J. S., Pedersen, Lotte Bang & Christensen, Søren Tvorup, 2018, In: Journal of Cell Biology. 217, 1, p. 151-161 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
Morthorst, Stine Kjær, Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2018, In: F E B S Journal. 285, 24, p. 4535-4564Research output: Contribution to journal › Review › Research › peer-review
- Published
TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms
Rosengren, T., Larsen, L. J., Pedersen, Lotte Bang, Christensen, Søren Tvorup & Møller, L. B., 2018, In: Cellular and Molecular Life Sciences. 75, 14, p. 2663-2680 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development
Rasmussen, K. K., Skat-Rørdam, Josephine, Andersen, P., Warzecha, C. B., Pye, M., Andersen, T. A., Ajbro, K. D., Bendsen, E., Narimatsu, M., Vilhardt, Frederik, Pedersen, Lotte Bang, Wrana, J. L., Anderson, R. H., Møllgård, Kjeld, Christensen, Søren Tvorup & Larsen, Lars Allan, 2018, In: Scientific Reports. 8, 1, 14 p., 9542.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Hot spots of N2O emission move with the seasonally mobile oxic-anoxic interface in drained organic soils
Lee, A. J., Winther, M. N., Priemé, Anders, Blunier, Thomas & Christensen, Søren Tvorup, 1 Dec 2017, In: Soil Biology & Biochemistry. 115, p. 178-186 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human embryonic stem cell derived cardiomyocytes self-arrange with areas of different subtypes during differentiation
Vestergaard, M. L., Grubb, Søren, Rasmussen, K. K., Anderson-Jenkins, Z. L., Grunnet-Lauridsen, K., Callø, Kirstine, Clausen, C., Christensen, Søren Tvorup, Møllgård, Kjeld & tcg964, tcg964, 1 Nov 2017, In: Stem Cells and Development. 26, 21, p. 1566-1577 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Patient-specific three-dimensional explant spheroids derived from human nasal airway epithelium: a simple methodological approach for ex vivo studies of primary ciliary dyskinesia
Marthin, J. K., Stevens, E. M., Larsen, Lars Allan, Christensen, Søren Tvorup & Nielsen, Kim G., 23 Mar 2017, In: Cilia. 6, 9 p., 3.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.
Schou, K. B., Mogensen, J. B., Morthorst, Stine Kjær, Nielsen, B. S., Aleliunaite, A., Serra-Marques, A., Fürstenberg, N., Saunier, S., Bizet, A. A., Veland, I. R., Akhmanova, A., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 30 Jan 2017, In: Nature Communications. 8, 15 p., 14177.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutation of the planar cell polarity gene VANGL1 in adolescent idiopathic scoliosis
Andersen, M. R., Farooq, M., Rasmussen, K. K., Kjaer, K. W., Simony, A., Christensen, Søren Tvorup & Larsen, Lars Allan, 2017, In: Spine. 42, 12, p. E702–E707 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Primary cilia and coordination of receptor tyrosine kinase (RTK) and transforming growth factor β (TGF-β) signaling
Christensen, Søren Tvorup, Morthorst, Stine Kjær, Mogensen, J. B. & Pedersen, Lotte Bang, 2017, In: Cold Spring Harbor Perspectives in Biology. 9, 6, 18 p., a028167.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Cilia and flagella
Schmid, F. M., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2016, Encyclopedia of cell biology. Bradshaw, R. A. & Stahl, P. D. (eds.). 1 ed. Elsevier, Vol. 2. p. 660-676 17 p.Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Research › peer-review
- Published
Endocytic control of cellular signaling at the primary cilium
Pedersen, Lotte Bang, Mogensen, J. B. & Christensen, Søren Tvorup, 2016, In: Trends in Biochemical Sciences. 41, 9, p. 784-797 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Immunofluorescence Microscopy and mRNA Analysis of Human Embryonic Stem Cells (hESCs) Including Primary Cilia Associated Signaling Pathways
Vestergaard, M. L., Awan, A., Warzecha, C. B., Christensen, Søren Tvorup & tcg964, tcg964, 2016, Human Embryonic Stem Cell Protocols. Springer Science+Business Media, Vol. 1307. p. 123-140 (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
TGFβ1-induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner
Labour, M., Riffault, M., Christensen, Søren Tvorup & Hoey, D. A., 2016, In: Scientific Reports. 6, 13 p., 35542.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The intraflagellar transport machinery in ciliary signaling
Mourão, A., Christensen, Søren Tvorup & Lorentzen, E., 2016, In: Current Opinion in Structural Biology. 41, p. 98-108 11 p.Research output: Contribution to journal › Review › Research › peer-review
- 2015
- Published
Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells
Nygaard, M. B., Almstrup, Kristian, Lindbæk, L., Christensen, Søren Tvorup & Svingen, T., 2015, In: Scientific Reports. 5, 14 p., 10364 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Coordination of TGFβ/BMP signaling is associated with the primary cilium
Lindbæk, L., Warzecha, C. B., Koefoed, K., Mogensen, J. B., Schmid, F., Pedersen, Lotte Bang, Larsen, Lars Allan & Christensen, Søren Tvorup, 2015, In: Cilia. 4, Suppl. 1, 1 p., P17.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Evolutionary implications of localization of the signaling scaffold protein Parafusin to both cilia and the nucleus
Satir, B. H., Wyroba, E., Liu, L., Lethan, M., Satir, P. & Christensen, Søren Tvorup, 2015, In: Cell Biology International. 39, 2, p. 136-145 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of the oncogenic, constitutive active Platelet-Derived Growth Factor Receptor alpha D842V mutant induces loss of primary cilia
Nielsen, B. S., Schmid, F., Malinda, R., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2015, In: Cilia. 4, Suppl. 1, 1 p., P63.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Ins and outs of GPCR signaling in primary cilia
Schou, K. B., Pedersen, Lotte Bang & Christensen, Søren Tvorup, 2015, In: E M B O Reports. 16, 9, p. 1099-1113 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Kinesin-3 motor protein KIF13B localizes to centrosomes and primary cilia and regulates ciliary length and signaling
Schou, K. B., Mogensen, J. B., Aleliunaite, A., Morthorst, Stine Kjær, Veland, I., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2015, In: Cilia. 4, Suppl. 1, 1 p., O3.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism
Nielsen, B. S., Malinda, R. R., Schmid, F. M., Pedersen, Stine Helene Falsig, Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2015, In: Journal of Cell Science. 128, p. 3543-3549 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Cilia and coordination of signaling networks during heart development
Koefoed, K., Veland, I. R., Pedersen, Lotte Bang, Larsen, Lars Allan & Christensen, Søren Tvorup, 2014, In: Organogenesis. 10, 1, p. 108-125 18 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8
Schou, K. B., Morthorst, Stine Kjær, Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2014, In: Cilia. 3, 6, 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomic analysis of bovine blastocoel fluid and blastocyst cells
Jensen, P. L., Grøndahl, M. L., Beck, H. C., Petersen, J., Stroebech, L., Christensen, Søren Tvorup & tcg964, tcg964, 2014, In: Systems Biology in Reproductive Medicine. 60, 3, p. 127-135 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Analysis of primary cilia in directional cell migration in fibroblasts
Christensen, Søren Tvorup, Veland, I., Schwab, A., Cammer, M. & Satir, P., 2013, In: Methods in Enzymology. 525, p. 45-58 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration
Veland, I. R., Montjean, R., Eley, L., Pedersen, Lotte Bang, Schwab, A., Goodship, J., Kristiansen, Karsten, Pedersen, Stine Helene Falsig, Saunier, S. & Christensen, Søren Tvorup, 2013, In: P L o S One. 8, 4, 15 p., e60193.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PDGFR alpha signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90(RSK) and AKT signaling pathways
Clement, Ditte Lynge, Mally, S., Stock, C., Lethan, M., Satir, P., Schwab, A., Pedersen, Stine Helene Falsig & Christensen, Søren Tvorup, 2013, In: Journal of Cell Science. 126, 4, p. 953-965 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4693
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Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration
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Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8
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Primary cilia and aberrant cell signaling in epithelial ovarian cancer
Research output: Contribution to journal › Journal article › Research › peer-review
Published