Stine Helene Falsig Pedersen

Stine Helene Falsig Pedersen

Professor

ORCID: 0000-0002-3044-7714

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  1. Published

    Assessment of different 3D culture systems to study tumor phenotype and chemosensitivity in pancreatic ductal adenocarcinoma

    Zeeberg, K., Cardone, R. A., Greco, M. R., Saccomano, M., Nøhr-Nielsen, A., Alves, F., Pedersen, Stine Helene Falsig & Reshkin, S. J., 2016, In: International Journal of Oncology. 49, 1, p. 243-252 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Cancer Cell Acid Adaptation Gene Expression Response is Correlated to Tumor-Specific Tissue Expression Profiles and Patient Survival

    Yao, Jiayi, Czaplinska, D., Ialchina, Renata, Schnipper, J., Liu, B., Sandelin, Albin Gustav & Pedersen, Stine Helene Falsig, 2020, In: Cancers. 12, 8, 27 p., 2183.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Regulation of the expression and subcellular localization of the taurine transporter TauT in mouse NIH3T3 fibroblasts

    Voss, J. W., Pedersen, Stine Helene Falsig, Christensen, Søren Tvorup & Lambert, Ian Henry, 2004, In: European Journal of Biochemistry. 271, p. 4646-4658

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration

    Veland, I. R., Montjean, R., Eley, L., Pedersen, Lotte Bang, Schwab, A., Goodship, J., Kristiansen, Karsten, Pedersen, Stine Helene Falsig, Saunier, S. & Christensen, Søren Tvorup, 2013, In: P L o S One. 8, 4, 15 p., e60193.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    The in vitro blood-brain barrier model under OGD condition

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2 Nov 2015.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  6. Published

    Modeling the ischemic blood-brain barrier; the effects of oxygen-glucose deprivation (OGD) on endothelial cells in culture

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig, Waagepetersen, Helle S. & Larsen, Birger Brodin, 19 Jun 2016.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  7. Published

    Changes in barrier properties and protein expression levels of bovine brain endothelial cells during oxygen-glucose deprivation (OGD)

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 27 Aug 2015.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  8. Published

    Changes in protein expression levels, Claudin-5 localization and barrier function in bovine brain endothelial cells during oxygen-glucose deprivation (OGD)

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 4 Jul 2015.

    Research output: Contribution to conference › Conference abstract for conference › Communication

  9. Published

    Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures

    Tornabene, E., Helms, H. C. C., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2019, In: PLoS ONE. 14, 8, 20 p., e0221103.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    A bovine in vitro blood-brain barrier model under oxygenglucose deprivation (OGD) condition

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2016.

    Research output: Contribution to conference › Poster › Research

  11. Published

    Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response

    Thirone, A. C. P., Speight, P., Zulys, M., Rotstein, O. D., Szaszi, K., Pedersen, Stine Helene Falsig & Kapus, A., 2009, In: American Journal of Physiology: Cell Physiology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4

    Thiesen, L., Belew, Zeinu Mussa, Griem-Krey, Nane, Pedersen, Stine Helene Falsig, Crocoll, C., Nour-Eldin, Hussam Hassan & Wellendorph, Petrine, 15 Feb 2020, In: European Journal of Pharmaceutical Sciences. 143, p. 1-9 105203.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    How protons pave the way to aggressive cancers

    Swietach, P., Boedtkjer, E. & Pedersen, Stine Helene Falsig, 2023, In: Nature Reviews Cancer. 23, p. 825-841 17 p.

    Research output: Contribution to journal › Review › Research › peer-review

  14. Published

    A unifying mechanism for Cancer cell death through ion channel activation by HAMLET

    Storm, P., Klausen, T. K., Trulsson, M., Ho CS, J., Dosnon, M., Westergren, T., Chao, Y., Rydström, A., Yang, H., Pedersen, Stine Helene Falsig & Svanborg, C., 2013, In: P L o S One. 8, 3, 18 p., e58578.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Roles of pH and the Na+/H+ exchanger NHE1 in cancer: from cell biology and animal models to an emerging translational perspective?

    Stock, C. & Pedersen, Stine Helene Falsig, Apr 2017, In: Seminars in Cancer Biology. 43, p. 5-16 12 p.

    Research output: Contribution to journal › Review › Research › peer-review

  16. Published

    Dynamic Na+/H+ exchanger 1 (NHE1) - calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation

    Sjøgaard-Frich, Lise Margrethe, Prestel, Andreas, Pedersen, E. S., Severin, M., Kristensen, Kristian Kølby, Olsen, Johan Gotthardt, Kragelund, Birthe Brandt & Pedersen, Stine Helene Falsig, 2021, In: eLife. 10, 29 p., e60889.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Constitutively active ErbB2 regulates cisplatin-induced cell death in breast cancer cells via pro- and antiapoptotic mechanisms

    Sigurðsson, H. H., Olesen, C. W., Dybboe, R., Lauritzen, G. & Pedersen, Stine Helene Falsig, 2015, In: Molecular Cancer Research. 13, 1, p. 63-77 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Dynamic localization of the Na+-HCO3- co-transporter NBCn1 to the plasma membrane, centrosomes, spindle and primary cilia

    Severin, M., Pedersen, E. L., Borre, M. T., Axholm, I., Christiansen, F. B., Ponniah, M., Czaplinska, D., Larsen, T., Pardo, L. A. & Pedersen, Stine Helene Falsig, 2023, In: Journal of Cell Science. 136, 7, 20 p., jcs260687.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Ion transport proteins control pancreatic cancer cell behaviour

    Schwab, A., Stock, C., Swietach, P., Hulikova, A., Vaughan-Jones, R. D., Pedersen, S. H. F., Andersen, A-D., Hoffmann, E. K., Novak, I., Reshkin, S., Prevarskaya, N., Lemonnier, L., Borowiec, A. S., Arcangeli, A., Zanieri, F., D´Amico, M., Fraser, S. P., Djamgoz, M. BA., Alves, F., Kalthoff, H. & 2 others, Pardo, L. A. & Stühmer, W., 2010, In: Acta Physiologica (Print Edition). 198, 677, p. 17 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  20. Published

    Ion transport proteins control pancreatic ductal adenocarcinoma

    Schwab, A., Stock, C., Swietach, P., Hulikova, A., Vaughan-Jones, R., Pedersen, S. H. F., Andersen, A. D., Hoffmann, E., Novak, I., Reshkin, S., Prevarskaya, N., Lemonnier, L., A-S, B., Fraser, S. P., Arcangeli, A., Zanieri, F., D'Amico, M., Kalthoff, H., Djamgoz, M. B., Alves, F. & 2 others, Pardo, L. & Stuehmer, W., 1 Oct 2010, In: Onkologie. 33, Suppl. 6, p. 269 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms

    Schrøder, J. M., Larsen, J., Komarova, Y., Akhmanova, A., Thorsteinsson, R. I., Grigoriev, I., Manguso, R., Christensen, Søren Tvorup, Pedersen, Stine Helene Falsig, Geimer, S. & Pedersen, Lotte Bang, 2011, In: Journal of Cell Science. 124, p. 2539-51 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair

    Schreml, S., Meier, R. J., Kirschbaum, M., Kong, S. C., Gehmert, S., Felthaus, O., Kuechler, S., Sharpe, J. R., Woeltje, K., Weiss, K. T., Albert, M., Seidl, U., Schroeder, J., Morsczeck, C., Prantl, L., Duschl, C., Pedersen, S. H. F., Gosau, M., Berneburg, M., Wolfbeis, O. S. & 2 others, Landthaler, M. & Babilas, P., 2014, In: Theranostics. 4, 7, p. 721-735 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Acid Adaptation Promotes TRPC1 Plasma Membrane Localization Leading to Pancreatic Ductal Adenocarcinoma Cell Proliferation and Migration through Ca2+ Entry and Interaction with PI3K/CaM

    Schnipper, J., Kouba, S., Hague, F., Girault, A., Telliez, M., Guenin, S., Ahidouch, A., Pedersen, Stine Helene Falsig & Ouadid-Ahidouch, H., 2022, In: Cancers. 14, 19, 27 p., 4946.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca2+-Independent Manner

    Schnipper, J., Kouba, S., Hague, F., Girault, A., Rybarczyk, P., Telliez, M., Guenin, S., Tebbakha, R., Sevestre, H., Ahidouch, A., Pedersen, Stine Helene Falsig & Ouadid-Ahidouch, H., 2022, In: International Journal of Molecular Sciences . 23, 14, 20 p., 7923.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    H-ras transformation sensitizes volume-activated anion channels and increases migratory activity of NIH3T3 fibroblasts.

    Schneider, L., Klausen, T. K., Stock, C., Mally, S., Christensen, Søren Tvorup, Pedersen, Stine Helene Falsig, Hoffmann, E. K. & Schwab, A., 2008, In: Pflügers Archiv: European Journal of Physiology. 455, 6, p. 1055-62 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium

    Schneider, L., Stock, C., Dieterich, P., Jensen, B. H., Pedersen, Lotte Bang, Satir, P., Schwab, A., Christensen, Søren Tvorup & Pedersen, Stine Helene Falsig, 2009, In: Journal of Cell Biology. 185, 1, p. 163-76 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC)

    Sauter, D. R. P., Novak, Ivana, Pedersen, Stine Helene Falsig, Larsen, Erik Hviid & Hoffmann, E. K., 2015, In: Pflügers Archiv - European Journal of Physiology. 467, 7, p. 1495-1508 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Myocardin-related transcription factor regulates Nox4 protein expression: linking cytoskeletal orginization to redox state

    Rozycki, M., Bialik, J. F., Speight, P., Dan, Q., Knudsen, Teresa Emmilie Toudal, Szeto, S. G., Yuen, D. A., Szászi, K., Pedersen, Stine Helene Falsig & Kapus, A., 2016, In: Journal of Biological Chemistry. 291, 1, p. 227-243 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer

    Rolver, M. G. & Pedersen, Stine Helene Falsig, 2021, In: British Journal of Cancer. 124, p. 1-2 2 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  30. Published

    Chronic acidosis rewires cancer cell metabolism through PPARα signaling

    Rolver, M. G., Holland, L. K. K., Ponniah, M., Prasad, N. S., Yao, Jiayi, Schnipper, J., Kramer, S., Elingaard-Larsen, L., Pedraz-Cuesta, E., Liu, B., Pardo, L. A., Maeda, K., Sandelin, Albin Gustav & Pedersen, Stine Helene Falsig, 2023, In: International Journal of Cancer. 152, 8, 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells

    Rolver, M. G., Elingaard-Larsen, L. O. & Pedersen, Stine Helene Falsig, 2019, In: Journal of Visualized Experiments. 2019, 148, e59714.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1

    Rolver, M. G., Elingaard-Larsen, L. O., Andersen, Anne Poder, Counillon, L. & Pedersen, Stine Helene Falsig, 2020, In: Scientific Reports. 10, 17 p., 5800.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Roles of Na+/H+ exchange in regulation of p38 mitogen-activated protein kinase activity and cell death after chemical anoxia in NIH3T3 fibroblasts.

    Rentsch, M. L., Ossum, C. G., Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2007, In: Pflügers Archiv: European Journal of Physiology. 454, 4, p. 649-62 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Effects of chemical anoxia on NHE1, p38 MAPK, p53, Akt and ERM proteins in NIH3T3 fibroblasts: evidence for a role of NHE1 upstream of p38 MAPK

    Rentsch, M. L., Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2006, In: The FASEB Journal. 5, p. A1158

    Research output: Contribution to journal › Conference abstract in journal › Research

  35. Published

    Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications

    Rasmussen, M., Alexander, R. T., Darborg, B. V., Møbjerg, Nadja, Hoffmann, E. K., Kapus , A. & Pedersen, Stine Helene Falsig, 2008, In: American Journal of Physiology: Cell Physiology. 294, 1, p. C197-C212 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells

    Rasmussen, L. J. H., Mûller, H. S. H., Jørgensen, B., Pedersen, Stine Helene Falsig & Hoffmann, E. K., 2015, In: American Journal of Physiology: Cell Physiology. 308, 2, p. C101-C110 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Induction of group VIA phospholipase A2 activity during in vitro ischemia in C2C12 myotubes is associated with changes in the level of its splice variants.

    Poulsen, K. A., Pedersen, Stine Helene Falsig, Kolko, M. & Lambert, Ian Henry, 2007, In: American Journal of Physiology: Cell Physiology. 293, 5, p. C1605-15

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Snowpack fluxes of methane and carbon dioxide from high Arctic tundra

    Pirk, N., Tamstorf, M. P., Lund, M., Mastepanov, M., Pedersen, Stine Helene Falsig, Mylius, M. R., Parmentier, F. W., Christiansen, H. H. & Christensen, T. R., 2016, In: Journal of Geophysical Research: Biogeosciences. 121, 11, p. 2886-2900 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    The Na+/H+ exchanger, NHE1, differentially regulates mitogen-activated protein kinase subfamilies after osmotic shrinkage in Ehrlich Lettre Ascites cells.

    Pedersen, Stine Helene Falsig, Rasmussen, M., Darborg, B. V., Nylandsted, J. & Hoffmann, E. K., 2007, In: Cellular Physiology and Biochemistry. 20, 6, p. 735-50 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    MCT1 and MCT4 expression and lactate flux activity increase during white and brown adipogenesis and impact adipocyte metabolism

    Petersen, C., Nielsen, M. D., Andersen, E. S., Basse, A. L., Isidor, Marie Sophie, Markussen, L. K., Viuff, B. M., Lambert, Ian Henry, Hansen, Jacob B. & Pedersen, Stine Helene Falsig, 12 Oct 2017, In: Scientific Reports. 7, 1, 13 p., 13101.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Prolactin signaling stimulates invasion via Na+/H+ exchanger NHE1 in T47D human breast cancer cells

    Pedraz Cuesta, E., Fredsted, J., Jensen, H. H., Bornebusch, A., Nejsum, L. N., Kragelund, Birthe Brandt & Pedersen, Stine Helene Falsig, 2016, In: Molecular Endocrinology. 30, 7, p. 693-708 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Mechanical stress induces release of ATP from Ehrlich ascites tumor cells.

    Pedersen, S., Pedersen, Stine Helene Falsig, Nilius, B., Lambert, Ian Henry & Hoffmann, E. K., 1999, In: BBA General Subjects. 1416, p. 271-284

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Acid–base transporters in the context of tumor heterogeneity

    Pedersen, Stine Helene Falsig, 2024, In: Pflugers Archiv European Journal of Physiology. 476, p. 689–701 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  44. Published

    Roles of phospholipase A2 isoforms in swelling- and melittin-induced arachidonic acid release and taurine efflux in NIH3T3 fibroblasts.

    Pedersen, Stine Helene Falsig, Poulsen, K. A. & Lambert, Ian Henry, 2006, In: American Journal of Physiology: Cell Physiology. 291, 6, p. C 1286-1296

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Osmosensory mechanisms in cellular and systemic volume regulation

    Pedersen, Stine Helene Falsig, Kapus, A. & Hoffmann, E. K., 2011, In: Journal of the American Society of Nephrology. 22, 9, p. 1587-97 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Cell volume regulation in epithelial physiology and cancer

    Pedersen, Stine Helene Falsig, Hoffmann, E. K. & Novak, Ivana, 2013, In: Frontiers in Physiology. 4, 12 p., 233.

    Research output: Contribution to journal › Review › Research › peer-review

  47. Published

    Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1.

    Pedersen, Stine Helene Falsig, Darborg, B. V., Rentsch, M. L. & Rasmussen, M., 2006, In: Archives of Biochemistry and Biophysics. 462, 2, p. 195-201 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    The identification of a volume-regulated anion channel: an amazing Odyssey

    Pedersen, Stine Helene Falsig, Klausen, T. K. & Nilius, B., 2015, In: Acta Physiologica (Print). 213, 4, p. 868-881 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  49. Published

    Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells.

    Pedersen, Stine Helene Falsig, Varming, C., Christensen, Søren Tvorup & Hoffmann, E. K., 2002, In: Journal of Membrane Biology. 189, 1, p. 67-81 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Alternating pH landscapes shape epithelial cancer initiation and progression: focus on pancreatic cancer

    Pedersen, Stine Helene Falsig, Novak, Ivana, Alves, F., Schwab, A. & Pardo, L. A., Jun 2017, In: BioEssays. 39, 6, 10 p., 1600253.

    Research output: Contribution to journal › Journal article › Research › peer-review

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