Stine Helene Falsig Pedersen

Stine Helene Falsig Pedersen

Professor

ORCID: 0000-0002-3044-7714

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  1. Published

    Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison

    Panou, D. A., Pedersen, Stine Helene Falsig, Kristensen, Mie & Nielsen, Hanne Mørck, 2023, In: Frontiers in Drug Delivery. 3, 16 p., 1221628.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer

    Pedersen, A., Mendes Lopes de Melo, J., Mørup, N., Tritsaris, Katerina & Pedersen, Stine Helene Falsig, 2017, In: BMC Cancer. 17, 15 p., 542.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Glycosylation of solute carriers: mechanisms and functional consequences

    Pedersen, N. B., Carlsson, M. C. & Pedersen, Stine Helene Falsig, 2016, In: Pflügers Archiv - European Journal of Physiology. 468, 2, p. 159-176 18 p.

    Research output: Contribution to journal › Review › Research › peer-review

  4. Published

    The SLC9A-C Mammalian Na+/H+ Exchanger Family: Molecules, Mechanisms, and Physiology

    Pedersen, Stine Helene Falsig & Counillon, L., 2019, In: Physiological Reviews. 99, 4, p. 2015-2113 99 p.

    Research output: Contribution to journal › Review › Research › peer-review

  5. Published

    Physiology and pathophysiology of Na+/H+ exchange and Na+-K+-2Cl- cotransport in the heart, brain, and blood

    Pedersen, Stine Helene Falsig, O´Donnell, M. E., Anderson, S. E. & Cala, P. M., 2006, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 291, 1, p. R1-R25

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Rho family GTP binding proteins are involved in the regulatory volume decrease process in NIH3T3 mouse fibroblasts.

    Pedersen, Stine Helene Falsig, Beisner, K. H., Willumsen, Berthe Marie, Lambert, Ian Henry & Hoffmann, E. K., 2002, In: Journal of Physiology. 541, Pt 3, p. 779-96 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity.

    Pedersen, Stine Helene Falsig, King, S. A., Nygaard, E. B., Rigor, R. R. & Cala, P. M., 2007, In: Journal of Biological Chemistry. 282, 27, p. 19716-27 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Molecular cloning of NHE1 from Winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A.

    Pedersen, Stine Helene Falsig, King, S. A., Rigor, R. R., Zhuang, Z., Warren, J. M. & Cala, P. M., 2003, In: American Journal of Physiology.. Vol. 284 (6), p. C1561-C1576

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer

    Pedersen, Stine Helene Falsig, Flinck, M. & Pardo, L. A., 2021, In: International Journal of Molecular Sciences. 22, 10, 27 p., 5209.

    Research output: Contribution to journal › Review › Research › peer-review

  10. Published

    Mechanisms of pHi regulation studied in individual neurons cultured from mouse cerebral cortex

    Pedersen, Stine Helene Falsig, Jørgensen, N. K., Damgaard, I., Schousboe, A. & Hoffmann, E. K., 1998, In: Journal of Neuroscience Research. 51, p. 431-441

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Role of the F-actin cytoskeleton in the RVD and RVI processes in Ehrlich ascites tumor cells.

    Pedersen, Stine Helene Falsig, Mills, J. W. & Hoffmann, E. K., 1999, In: Experimental Cell Research. 252, p. 63-74

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Separate swelling- og Ca2+-activated anion currents in Ehrlich ascites tumor cells

    Pedersen, Stine Helene Falsig, Prenen, J., Droogmans, G., Hoffmann, E. K. & Nilius, B., 1998, In: J. Membrane Biol.. 163, p. 97-110

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Molecular cloning of NHE1 from Winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A

    Pedersen, Stine Helene Falsig, King, S. A., Rigor, R. R., Zhuang, Z., Warren, J. M. & Cala, P. M., 2003, In: FASEB Journal. Vol. 19 (4), p. A 139- A 140

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The Na+/H+ Exchange system in Ehrlich ascites tumour cells. Effects of cell volume, phosphorylation and calcium.

    Pedersen, Stine Helene Falsig, Kramhøft, B., Jørgensen, N. K. & Hoffmann, E. K., 1994, In: Acta Physiologica (Print Edition). 151(4), p. 26A

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The cytoskeleton and cell volume regulation

    Pedersen, Stine Helene Falsig, Hoffmann, E. K. & Mills, J. W., 2001, In: Comparative Biochemistry and Physiology Part A. 130, p. 385-399

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Dynamics of Ca2+i and pHi in Ehrlich ascites tumor cells after Ca2+-mobilizing agonists or exposure to hypertonic solution

    Pedersen, Stine Helene Falsig, Jørgensen, N. K. & Hoffmann, E. K., 1998, In: Pflügers Archiv: European Journal of Physiology. 436, 2, p. 199-210

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Signal transduction mechanisms involved in the rgulation of NHE1 from Pseudopleuronectes Americanus red blood cells by osmotic shrinkage , ß-adrenergic stimuli, and calyculin A

    Pedersen, Stine Helene Falsig, Holt, M., King, S. A. & Cala, P. M., 2004, In: Bull. Mount Desert Island Biol. Lab. 43, p. 9-11

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Possible Interrelationship between Changes in F-actin and Myosin II, Protein Phosphorylation and Cell Volume Regulation in Ehrlich Ascites Tumor Cells

    Pedersen, Stine Helene Falsig & Hoffmann, E. K., 2002, In: Experimental Cell Research. 277, p. 57-73

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    P2 receptor-mediated signal transduction in Ehrlich ascites tumor cells

    Pedersen, Stine Helene Falsig, Pedersen, S., Lambert, Ian Henry & Hoffmann, E. K., 1998, In: BBA General Subjects. 1374, p. 94-106

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Hsp-70 mediated protection of WEHI cells against hypertonic stress-induced programmed cell death by a mechanism independent of effects on volume-regulatory membrane transport proteins

    Pedersen, Stine Helene Falsig, Larsen, J. N., Hoffmann, E. K. & Jaattela, M., 2004, In: The FASEB Journal. 18 (5), p. A1284 suppl.s.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Transient receptor potential channels in mechanosensing and cell volume regulation.

    Pedersen, Stine Helene Falsig & Nilius, B., 2007, In: Methods in Enzymology. 428, p. 183-207 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Comparative biology of the ubiquitous Na+/H+ exchanger, NHE1: lessons from erythrocytes.

    Pedersen, Stine Helene Falsig & Cala, P. M., 2004, In: Journal of experimental zoology. Part A, Comparative experimental biology. 301, 7, p. 569-78 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    A novel NHE1 from red blood cells of the winter flounder: regulation by multiple signaling pathways.

    Pedersen, Stine Helene Falsig, 2004, In: Advances in Experimental Medicine and Biology. 559, p. 89-98 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    TRP channels: an overview.

    Pedersen, Stine Helene Falsig, Owsianik, G. & Nilius, B., 2005, In: Cell Calcium. 38, 3-4, p. 233-52 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    The Na+/H+ exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death.

    Pedersen, Stine Helene Falsig, 2006, In: Pflügers Archiv: European Journal of Physiology. 452, 3, p. 249-59 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Acid–base transporters in the context of tumor heterogeneity

    Pedersen, Stine Helene Falsig, 2024, In: Pflugers Archiv European Journal of Physiology. 476, p. 689–701 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  27. Published

    Ion channels and transporters in cancer: pathophysiology, regulation, and clinical potential

    Pedersen, Stine Helene Falsig & Stock, C., 2013, In: Cancer Research. 73, 6, p. 1658-1661 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Biophysics and physiology of the volume-regulated anion channel (VRAC)/volume-sensitive outwardly rectifying anion channel (VSOR)

    Pedersen, Stine Helene Falsig, Okada, Y. & Nilius, B., 2016, In: Pflügers Archiv - European Journal of Physiology. 468, 3, p. 371-383 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Roles of phospholipase A2 isoforms in swelling- and melittin-induced arachidonic acid release and taurine efflux in NIH3T3 fibroblasts.

    Pedersen, Stine Helene Falsig, Poulsen, K. A. & Lambert, Ian Henry, 2006, In: American Journal of Physiology: Cell Physiology. 291, 6, p. C 1286-1296

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Osmosensory mechanisms in cellular and systemic volume regulation

    Pedersen, Stine Helene Falsig, Kapus, A. & Hoffmann, E. K., 2011, In: Journal of the American Society of Nephrology. 22, 9, p. 1587-97 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Cell volume regulation in epithelial physiology and cancer

    Pedersen, Stine Helene Falsig, Hoffmann, E. K. & Novak, Ivana, 2013, In: Frontiers in Physiology. 4, 12 p., 233.

    Research output: Contribution to journal › Review › Research › peer-review

  32. Published

    Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1.

    Pedersen, Stine Helene Falsig, Darborg, B. V., Rentsch, M. L. & Rasmussen, M., 2006, In: Archives of Biochemistry and Biophysics. 462, 2, p. 195-201 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    The identification of a volume-regulated anion channel: an amazing Odyssey

    Pedersen, Stine Helene Falsig, Klausen, T. K. & Nilius, B., 2015, In: Acta Physiologica (Print). 213, 4, p. 868-881 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells.

    Pedersen, Stine Helene Falsig, Varming, C., Christensen, Søren Tvorup & Hoffmann, E. K., 2002, In: Journal of Membrane Biology. 189, 1, p. 67-81 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Alternating pH landscapes shape epithelial cancer initiation and progression: focus on pancreatic cancer

    Pedersen, Stine Helene Falsig, Novak, Ivana, Alves, F., Schwab, A. & Pardo, L. A., Jun 2017, In: BioEssays. 39, 6, 10 p., 1600253.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Mechanical stress induces release of ATP from Ehrlich ascites tumor cells.

    Pedersen, S., Pedersen, Stine Helene Falsig, Nilius, B., Lambert, Ian Henry & Hoffmann, E. K., 1999, In: BBA General Subjects. 1416, p. 271-284

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Prolactin signaling stimulates invasion via Na+/H+ exchanger NHE1 in T47D human breast cancer cells

    Pedraz Cuesta, E., Fredsted, J., Jensen, H. H., Bornebusch, A., Nejsum, L. N., Kragelund, Birthe Brandt & Pedersen, Stine Helene Falsig, 2016, In: Molecular Endocrinology. 30, 7, p. 693-708 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    MCT1 and MCT4 expression and lactate flux activity increase during white and brown adipogenesis and impact adipocyte metabolism

    Petersen, C., Nielsen, M. D., Andersen, E. S., Basse, A. L., Isidor, Marie Sophie, Markussen, L. K., Viuff, B. M., Lambert, Ian Henry, Hansen, Jacob B. & Pedersen, Stine Helene Falsig, 12 Oct 2017, In: Scientific Reports. 7, 1, 13 p., 13101.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    The Na+/H+ exchanger, NHE1, differentially regulates mitogen-activated protein kinase subfamilies after osmotic shrinkage in Ehrlich Lettre Ascites cells.

    Pedersen, Stine Helene Falsig, Rasmussen, M., Darborg, B. V., Nylandsted, J. & Hoffmann, E. K., 2007, In: Cellular Physiology and Biochemistry. 20, 6, p. 735-50 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Snowpack fluxes of methane and carbon dioxide from high Arctic tundra

    Pirk, N., Tamstorf, M. P., Lund, M., Mastepanov, M., Pedersen, Stine Helene Falsig, Mylius, M. R., Parmentier, F. W., Christiansen, H. H. & Christensen, T. R., 2016, In: Journal of Geophysical Research: Biogeosciences. 121, 11, p. 2886-2900 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Induction of group VIA phospholipase A2 activity during in vitro ischemia in C2C12 myotubes is associated with changes in the level of its splice variants.

    Poulsen, K. A., Pedersen, Stine Helene Falsig, Kolko, M. & Lambert, Ian Henry, 2007, In: American Journal of Physiology: Cell Physiology. 293, 5, p. C1605-15

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells

    Rasmussen, L. J. H., Mûller, H. S. H., Jørgensen, B., Pedersen, Stine Helene Falsig & Hoffmann, E. K., 2015, In: American Journal of Physiology: Cell Physiology. 308, 2, p. C101-C110 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications

    Rasmussen, M., Alexander, R. T., Darborg, B. V., Møbjerg, Nadja, Hoffmann, E. K., Kapus , A. & Pedersen, Stine Helene Falsig, 2008, In: American Journal of Physiology: Cell Physiology. 294, 1, p. C197-C212 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Effects of chemical anoxia on NHE1, p38 MAPK, p53, Akt and ERM proteins in NIH3T3 fibroblasts: evidence for a role of NHE1 upstream of p38 MAPK

    Rentsch, M. L., Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2006, In: The FASEB Journal. 5, p. A1158

    Research output: Contribution to journal › Conference abstract in journal › Research

  45. Published

    Roles of Na+/H+ exchange in regulation of p38 mitogen-activated protein kinase activity and cell death after chemical anoxia in NIH3T3 fibroblasts.

    Rentsch, M. L., Ossum, C. G., Hoffmann, E. K. & Pedersen, Stine Helene Falsig, 2007, In: Pflügers Archiv: European Journal of Physiology. 454, 4, p. 649-62 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Chronic acidosis rewires cancer cell metabolism through PPARα signaling

    Rolver, M. G., Holland, L. K. K., Ponniah, M., Prasad, N. S., Yao, Jiayi, Schnipper, J., Kramer, S., Elingaard-Larsen, L., Pedraz-Cuesta, E., Liu, B., Pardo, L. A., Maeda, K., Sandelin, Albin Gustav & Pedersen, Stine Helene Falsig, 2023, In: International Journal of Cancer. 152, 8, 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells

    Rolver, M. G., Elingaard-Larsen, L. O. & Pedersen, Stine Helene Falsig, 2019, In: Journal of Visualized Experiments. 2019, 148, e59714.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1

    Rolver, M. G., Elingaard-Larsen, L. O., Andersen, Anne Poder, Counillon, L. & Pedersen, Stine Helene Falsig, 2020, In: Scientific Reports. 10, 17 p., 5800.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer

    Rolver, M. G. & Pedersen, Stine Helene Falsig, 2021, In: British Journal of Cancer. 124, p. 1-2 2 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  50. Published

    Myocardin-related transcription factor regulates Nox4 protein expression: linking cytoskeletal orginization to redox state

    Rozycki, M., Bialik, J. F., Speight, P., Dan, Q., Knudsen, Teresa Emmilie Toudal, Szeto, S. G., Yuen, D. A., Szászi, K., Pedersen, Stine Helene Falsig & Kapus, A., 2016, In: Journal of Biological Chemistry. 291, 1, p. 227-243 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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