A mathematical model of amphibian skin epithelium with two types of transporting cellular units

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A mathematical model of amphibian skin epithelium with two types of transporting cellular units. / Larsen, Erik Hviid; Rasmussen, B E.

In: Pflügers Archiv - European journal of physiology, Vol. 405 Suppl 1, 1985, p. S50-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Larsen, EH & Rasmussen, BE 1985, 'A mathematical model of amphibian skin epithelium with two types of transporting cellular units', Pflügers Archiv - European journal of physiology, vol. 405 Suppl 1, pp. S50-8.

APA

Larsen, E. H., & Rasmussen, B. E. (1985). A mathematical model of amphibian skin epithelium with two types of transporting cellular units. Pflügers Archiv - European journal of physiology, 405 Suppl 1, S50-8.

Vancouver

Larsen EH, Rasmussen BE. A mathematical model of amphibian skin epithelium with two types of transporting cellular units. Pflügers Archiv - European journal of physiology. 1985;405 Suppl 1:S50-8.

Author

Larsen, Erik Hviid ; Rasmussen, B E. / A mathematical model of amphibian skin epithelium with two types of transporting cellular units. In: Pflügers Archiv - European journal of physiology. 1985 ; Vol. 405 Suppl 1. pp. S50-8.

Bibtex

@article{af4c2d6d5c4f4d98bc25d0797cad1796,
title = "A mathematical model of amphibian skin epithelium with two types of transporting cellular units",
abstract = "A computer model of ion transport across amphibian skin epithelium containing two types of cellular units, their relative number and sizes, and a paracellular pathway has been developed. The two cellular units are, a large Na+ transporting compartment representing the major epithelium from stratum granulosum to str. germinativum, and a small, Cl- transporting compartment representing the mitochondria rich cell. The cellular units both contain dissipative and active pathways according to the two-membrane model. The Na+ transporting unit includes a (Na+, K+, 2 Cl-) co-transport system in the inward facing membrane. The outward facing membrane of the Cl- transporting units contains a potential gated Cl- permeability. Effects of ion distributions and changes in gating variables on the time course of transepithelial voltage clamp currents and their steady states are analyzed. The model predicts communication between the two cellular units under open circuit conditions.",
keywords = "Amphibians, Animals, Biological Transport, Active, Cell Membrane, Cell Membrane Permeability, Chlorides, Epithelium, Kinetics, Mathematics, Membrane Potentials, Models, Biological, Potassium, Skin, Sodium",
author = "Larsen, {Erik Hviid} and Rasmussen, {B E}",
year = "1985",
language = "English",
volume = "405 Suppl 1",
pages = "S50--8",
journal = "Pfl{\"u}gers Archiv - European Journal of Physiology",
issn = "0031-6768",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - A mathematical model of amphibian skin epithelium with two types of transporting cellular units

AU - Larsen, Erik Hviid

AU - Rasmussen, B E

PY - 1985

Y1 - 1985

N2 - A computer model of ion transport across amphibian skin epithelium containing two types of cellular units, their relative number and sizes, and a paracellular pathway has been developed. The two cellular units are, a large Na+ transporting compartment representing the major epithelium from stratum granulosum to str. germinativum, and a small, Cl- transporting compartment representing the mitochondria rich cell. The cellular units both contain dissipative and active pathways according to the two-membrane model. The Na+ transporting unit includes a (Na+, K+, 2 Cl-) co-transport system in the inward facing membrane. The outward facing membrane of the Cl- transporting units contains a potential gated Cl- permeability. Effects of ion distributions and changes in gating variables on the time course of transepithelial voltage clamp currents and their steady states are analyzed. The model predicts communication between the two cellular units under open circuit conditions.

AB - A computer model of ion transport across amphibian skin epithelium containing two types of cellular units, their relative number and sizes, and a paracellular pathway has been developed. The two cellular units are, a large Na+ transporting compartment representing the major epithelium from stratum granulosum to str. germinativum, and a small, Cl- transporting compartment representing the mitochondria rich cell. The cellular units both contain dissipative and active pathways according to the two-membrane model. The Na+ transporting unit includes a (Na+, K+, 2 Cl-) co-transport system in the inward facing membrane. The outward facing membrane of the Cl- transporting units contains a potential gated Cl- permeability. Effects of ion distributions and changes in gating variables on the time course of transepithelial voltage clamp currents and their steady states are analyzed. The model predicts communication between the two cellular units under open circuit conditions.

KW - Amphibians

KW - Animals

KW - Biological Transport, Active

KW - Cell Membrane

KW - Cell Membrane Permeability

KW - Chlorides

KW - Epithelium

KW - Kinetics

KW - Mathematics

KW - Membrane Potentials

KW - Models, Biological

KW - Potassium

KW - Skin

KW - Sodium

M3 - Journal article

C2 - 4088838

VL - 405 Suppl 1

SP - S50-8

JO - Pflügers Archiv - European Journal of Physiology

JF - Pflügers Archiv - European Journal of Physiology

SN - 0031-6768

ER -

ID: 103933257