A role for the weak DnaA binding sites in bacterial replication origins
Research output: Contribution to journal › Journal article › Research › peer-review
DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an 'AT-rich' region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor et al. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.
Original language | English |
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Journal | Molecular Microbiology |
Volume | 82 |
Issue number | 2 |
Pages (from-to) | 272-274 |
Number of pages | 3 |
ISSN | 0950-382X |
DOIs | |
Publication status | Published - 2011 |
Externally published | Yes |
- Bacterial Proteins/chemistry, Binding Sites, Caulobacter crescentus/chemistry, Chromosomes, Bacterial/genetics, DNA Replication, DNA-Binding Proteins/chemistry, Protein Binding, Replication Origin
Research areas
ID: 200971366