Assembly of primary cilia.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Assembly of primary cilia. / Pedersen, Lotte B; Veland, Iben R; Schrøder, Jacob M; Christensen, Søren T.

In: Developmental Dynamics, Vol. 237, 2008, p. 1993-2006.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pedersen, LB, Veland, IR, Schrøder, JM & Christensen, ST 2008, 'Assembly of primary cilia.', Developmental Dynamics, vol. 237, pp. 1993-2006. https://doi.org/10.1002/dvdy.21521

APA

Pedersen, L. B., Veland, I. R., Schrøder, J. M., & Christensen, S. T. (2008). Assembly of primary cilia. Developmental Dynamics, 237, 1993-2006. https://doi.org/10.1002/dvdy.21521

Vancouver

Pedersen LB, Veland IR, Schrøder JM, Christensen ST. Assembly of primary cilia. Developmental Dynamics. 2008;237:1993-2006. https://doi.org/10.1002/dvdy.21521

Author

Pedersen, Lotte B ; Veland, Iben R ; Schrøder, Jacob M ; Christensen, Søren T. / Assembly of primary cilia. In: Developmental Dynamics. 2008 ; Vol. 237. pp. 1993-2006.

Bibtex

@article{2e18f67011df11ddbee902004c4f4f50,
title = "Assembly of primary cilia.",
abstract = "Primary cilia are microtubule-based, hair-like sensory organelles present on the surface of most growth-arrested cells in our body. Recent research has demonstrated a crucial role for primary cilia in regulating vertebrate developmental pathways and tissue homeostasis, and defects in genes involved in primary cilia assembly or function have been associated with a panoply of disorders and diseases, including polycystic kidney disease, left-right asymmetry defects, hydrocephalus, and Bardet Biedl Syndrome. Here we provide an up-to-date review focused on the molecular mechanisms involved in the assembly of primary cilia in vertebrate cells. We present an overview of the early stages of the cilia assembly process, as well as a description of the intraflagellar transport (IFT) system. IFT is a highly conserved process required for assembly of almost all eukaryotic cilia and flagella, and much of our current knowledge about IFT is based on studies performed in Chlamydomonas and Caenorhabditis elegans. Therefore, our review of the IFT literature includes studies performed in these two model organisms. The role of several non-IFT proteins (e.g., centrosomal proteins) in the ciliary assembly process is also discussed. Developmental Dynamics, 2008. (c) 2008 Wiley-Liss, Inc.",
author = "Pedersen, {Lotte B} and Veland, {Iben R} and Schr{\o}der, {Jacob M} and Christensen, {S{\o}ren T}",
note = "Keywords cilia • intraflagellar transport • kinesin • dynein",
year = "2008",
doi = "10.1002/dvdy.21521",
language = "English",
volume = "237",
pages = "1993--2006",
journal = "Developmental Dynamics",
issn = "1058-8388",
publisher = "JohnWiley & Sons, Inc.",

}

RIS

TY - JOUR

T1 - Assembly of primary cilia.

AU - Pedersen, Lotte B

AU - Veland, Iben R

AU - Schrøder, Jacob M

AU - Christensen, Søren T

N1 - Keywords cilia • intraflagellar transport • kinesin • dynein

PY - 2008

Y1 - 2008

N2 - Primary cilia are microtubule-based, hair-like sensory organelles present on the surface of most growth-arrested cells in our body. Recent research has demonstrated a crucial role for primary cilia in regulating vertebrate developmental pathways and tissue homeostasis, and defects in genes involved in primary cilia assembly or function have been associated with a panoply of disorders and diseases, including polycystic kidney disease, left-right asymmetry defects, hydrocephalus, and Bardet Biedl Syndrome. Here we provide an up-to-date review focused on the molecular mechanisms involved in the assembly of primary cilia in vertebrate cells. We present an overview of the early stages of the cilia assembly process, as well as a description of the intraflagellar transport (IFT) system. IFT is a highly conserved process required for assembly of almost all eukaryotic cilia and flagella, and much of our current knowledge about IFT is based on studies performed in Chlamydomonas and Caenorhabditis elegans. Therefore, our review of the IFT literature includes studies performed in these two model organisms. The role of several non-IFT proteins (e.g., centrosomal proteins) in the ciliary assembly process is also discussed. Developmental Dynamics, 2008. (c) 2008 Wiley-Liss, Inc.

AB - Primary cilia are microtubule-based, hair-like sensory organelles present on the surface of most growth-arrested cells in our body. Recent research has demonstrated a crucial role for primary cilia in regulating vertebrate developmental pathways and tissue homeostasis, and defects in genes involved in primary cilia assembly or function have been associated with a panoply of disorders and diseases, including polycystic kidney disease, left-right asymmetry defects, hydrocephalus, and Bardet Biedl Syndrome. Here we provide an up-to-date review focused on the molecular mechanisms involved in the assembly of primary cilia in vertebrate cells. We present an overview of the early stages of the cilia assembly process, as well as a description of the intraflagellar transport (IFT) system. IFT is a highly conserved process required for assembly of almost all eukaryotic cilia and flagella, and much of our current knowledge about IFT is based on studies performed in Chlamydomonas and Caenorhabditis elegans. Therefore, our review of the IFT literature includes studies performed in these two model organisms. The role of several non-IFT proteins (e.g., centrosomal proteins) in the ciliary assembly process is also discussed. Developmental Dynamics, 2008. (c) 2008 Wiley-Liss, Inc.

U2 - 10.1002/dvdy.21521

DO - 10.1002/dvdy.21521

M3 - Journal article

C2 - 18393310

VL - 237

SP - 1993

EP - 2006

JO - Developmental Dynamics

JF - Developmental Dynamics

SN - 1058-8388

ER -

ID: 3799321