Cilia and flagella
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Cilia and flagella. / Pedersen, Lotte Bang; Jurisch-Yaksi, Nathalie; Schmid, Fabian Marc; Christensen, Søren Tvorup.
Encyclopedia of Cell Biology, Second Edition. ed. / Ralph A Bradshaw; Gerald W. Hart; Philip D. Stahl. Vol. 3 2. ed. Oxford : Elsevier, 2023. p. 164-188.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Cilia and flagella
AU - Pedersen, Lotte Bang
AU - Jurisch-Yaksi, Nathalie
AU - Schmid, Fabian Marc
AU - Christensen, Søren Tvorup
N1 - Publisher Copyright: © 2023 Elsevier Inc. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Cilia and flagella are microtubule-based, rod-shaped organelles present on the surface of a variety of eukaryotic cells. They function in cell locomotion, flow of extracellular fluid across cell surfaces as well as in detection, transmission and integration of signals from the cellular surroundings. In vertebrates, cilia are critical for regulating developmental processes and tissue homeostasis. Consequently, genetic defects that impair ciliary function or assembly lead to a growing number of different human diseases. This class of diseases, called ciliopathies, is often pleiotropic affecting multiple organs and tissues in the body. Here we first provide an overview of general cilia structure, and discuss mechanisms of ciliary assembly and length control, including intraflagellar transport (IFT) and transcriptional control of motile cilia formation. Next, we describe how cilia coordinate their motility and signaling functions, and we conclude with a brief overview of ciliopathies and the main symptoms associated with these diseases
AB - Cilia and flagella are microtubule-based, rod-shaped organelles present on the surface of a variety of eukaryotic cells. They function in cell locomotion, flow of extracellular fluid across cell surfaces as well as in detection, transmission and integration of signals from the cellular surroundings. In vertebrates, cilia are critical for regulating developmental processes and tissue homeostasis. Consequently, genetic defects that impair ciliary function or assembly lead to a growing number of different human diseases. This class of diseases, called ciliopathies, is often pleiotropic affecting multiple organs and tissues in the body. Here we first provide an overview of general cilia structure, and discuss mechanisms of ciliary assembly and length control, including intraflagellar transport (IFT) and transcriptional control of motile cilia formation. Next, we describe how cilia coordinate their motility and signaling functions, and we conclude with a brief overview of ciliopathies and the main symptoms associated with these diseases
KW - Basal body
KW - Centriole
KW - Centrosome
KW - Cilia
KW - Ciliogenesis
KW - Ciliopathies
KW - Dynein
KW - Flagella
KW - Intraflagellar Transport
KW - Kinesin
KW - Microtubule
KW - Motility
KW - Signaling
KW - Transition zone
U2 - 10.1016/B978-0-12-821618-7.00209-1
DO - 10.1016/B978-0-12-821618-7.00209-1
M3 - Book chapter
AN - SCOPUS:85158962751
VL - 3
SP - 164
EP - 188
BT - Encyclopedia of Cell Biology, Second Edition
A2 - Bradshaw, Ralph A
A2 - Hart, Gerald W.
A2 - Stahl, Philip D.
PB - Elsevier
CY - Oxford
ER -
ID: 332189213