COP9 signalosome: a provider of DNA building blocks
Research output: Contribution to journal › Journal article › Research › peer-review
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COP9 signalosome: a provider of DNA building blocks. / Nielsen, Olaf.
In: Current Biology, Vol. 13, No. 14, 15.07.2003, p. R565-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - COP9 signalosome: a provider of DNA building blocks
AU - Nielsen, Olaf
PY - 2003/7/15
Y1 - 2003/7/15
N2 - In fission yeast, the COP9 signalosome is required to activate ribonucleotide reductase for DNA synthesis. This is mediated via the ubiquitin ligase Pcu4, activation of which leads to degradation of the scaffold protein Spd1, which anchors the small ribonucleotide reductase subunit in the nucleus away from the large subunit in the cytoplasm.
AB - In fission yeast, the COP9 signalosome is required to activate ribonucleotide reductase for DNA synthesis. This is mediated via the ubiquitin ligase Pcu4, activation of which leads to degradation of the scaffold protein Spd1, which anchors the small ribonucleotide reductase subunit in the nucleus away from the large subunit in the cytoplasm.
KW - Cell Cycle
KW - Cullin Proteins
KW - Models, Biological
KW - Multiprotein Complexes
KW - Peptide Hydrolases
KW - Proteins
KW - Ribonucleotide Reductases
KW - Schizosaccharomyces
KW - Ubiquitin-Protein Ligases
M3 - Journal article
C2 - 12867051
VL - 13
SP - R565-7
JO - Current Biology
JF - Current Biology
SN - 0960-9822
IS - 14
ER -
ID: 33577756