Guilt by association: what p120-catenin has to hide
Research output: Contribution to journal › Comment/debate › Research › peer-review
Members of the p120-catenin family associate with cadherins and regulate their stability at the plasma membrane. How p120-catenin limits cadherin endocytosis has long remained a mystery. In this issue, Nanes et al. (2012. J. Cell Biol. doi:10.1083/jcb.201205029) identify a conserved acidic motif within cadherins that acts as a physical platform for p120-catenin binding. However, in the absence of p120-catenin, the motif acts as an endocytic signal. These results provide new insight into p120-catenin's role as guardian of intercellular junction dynamics.
Original language | English |
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Journal | Journal of Cell Biology |
Volume | 199 |
Issue number | 2 |
Pages (from-to) | 211-214 |
Number of pages | 4 |
ISSN | 0021-9525 |
DOIs |
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Publication status | Published - 2012 |
Externally published | Yes |
- Adherens Junctions, Animals, Antigens, CD, Cadherins, Catenins, Endocytosis, Humans, Comment, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Research areas
ID: 188368581