High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts. / Christensen, Søren Tvorup; Voss, Jesper W.; Teilmann, Stefan C.; Lambert, Ian H.

In: Cell Biology International, Vol. 29, No. 5, 2005, p. 347-351.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Christensen, ST, Voss, JW, Teilmann, SC & Lambert, IH 2005, 'High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts', Cell Biology International, vol. 29, no. 5, pp. 347-351. https://doi.org/10.1016/j.cellbi.2005.02.003

APA

Christensen, S. T., Voss, J. W., Teilmann, S. C., & Lambert, I. H. (2005). High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts. Cell Biology International, 29(5), 347-351. https://doi.org/10.1016/j.cellbi.2005.02.003

Vancouver

Christensen ST, Voss JW, Teilmann SC, Lambert IH. High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts. Cell Biology International. 2005;29(5):347-351. https://doi.org/10.1016/j.cellbi.2005.02.003

Author

Christensen, Søren Tvorup ; Voss, Jesper W. ; Teilmann, Stefan C. ; Lambert, Ian H. / High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts. In: Cell Biology International. 2005 ; Vol. 29, No. 5. pp. 347-351.

Bibtex

@article{02d5cf406c3711dcbee902004c4f4f50,
title = "High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts",
abstract = "Taurine, present in high concentrations in various mammalian cells, is essential for regulation of cell volume, cellular oxidative status as well as the cellular Ca2+ homeostasis. Cellular taurine content is a balance between active uptake through the saturable, Na+-dependent taurine transporter TauT, and passive release via a volume-sensitive leak pathway. Here we demonstrate that: (i) TauT localizes to the primary cilium of growth-arrested NIH3T3 fibroblasts, (ii) long-term exposure to TNFa or hypertonic sucrose medium, i.e., growth medium supplemented with 100 mM sucrose, increases ciliary TauT expression and (iii) long-term exposure to hypertonic taurine medium, i.e., growth medium supplemented with 100 mM taurine, reduces ciliary TauT expression. These results point to an important role of taurine in the regulation of physiological processes located to the primary cilium.",
author = "Christensen, {S{\o}ren Tvorup} and Voss, {Jesper W.} and Teilmann, {Stefan C.} and Lambert, {Ian H.}",
note = "Keywords: Taurine transporter; NIH3T3 cells; Primary cilia; Ca2+ homeostasis; Ion channels; Tumour necrosis factor a",
year = "2005",
doi = "10.1016/j.cellbi.2005.02.003",
language = "English",
volume = "29",
pages = "347--351",
journal = "Cell Biology International",
issn = "1065-6995",
publisher = "Academic Press",
number = "5",

}

RIS

TY - JOUR

T1 - High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts

AU - Christensen, Søren Tvorup

AU - Voss, Jesper W.

AU - Teilmann, Stefan C.

AU - Lambert, Ian H.

N1 - Keywords: Taurine transporter; NIH3T3 cells; Primary cilia; Ca2+ homeostasis; Ion channels; Tumour necrosis factor a

PY - 2005

Y1 - 2005

N2 - Taurine, present in high concentrations in various mammalian cells, is essential for regulation of cell volume, cellular oxidative status as well as the cellular Ca2+ homeostasis. Cellular taurine content is a balance between active uptake through the saturable, Na+-dependent taurine transporter TauT, and passive release via a volume-sensitive leak pathway. Here we demonstrate that: (i) TauT localizes to the primary cilium of growth-arrested NIH3T3 fibroblasts, (ii) long-term exposure to TNFa or hypertonic sucrose medium, i.e., growth medium supplemented with 100 mM sucrose, increases ciliary TauT expression and (iii) long-term exposure to hypertonic taurine medium, i.e., growth medium supplemented with 100 mM taurine, reduces ciliary TauT expression. These results point to an important role of taurine in the regulation of physiological processes located to the primary cilium.

AB - Taurine, present in high concentrations in various mammalian cells, is essential for regulation of cell volume, cellular oxidative status as well as the cellular Ca2+ homeostasis. Cellular taurine content is a balance between active uptake through the saturable, Na+-dependent taurine transporter TauT, and passive release via a volume-sensitive leak pathway. Here we demonstrate that: (i) TauT localizes to the primary cilium of growth-arrested NIH3T3 fibroblasts, (ii) long-term exposure to TNFa or hypertonic sucrose medium, i.e., growth medium supplemented with 100 mM sucrose, increases ciliary TauT expression and (iii) long-term exposure to hypertonic taurine medium, i.e., growth medium supplemented with 100 mM taurine, reduces ciliary TauT expression. These results point to an important role of taurine in the regulation of physiological processes located to the primary cilium.

U2 - 10.1016/j.cellbi.2005.02.003

DO - 10.1016/j.cellbi.2005.02.003

M3 - Journal article

VL - 29

SP - 347

EP - 351

JO - Cell Biology International

JF - Cell Biology International

SN - 1065-6995

IS - 5

ER -

ID: 1093370