Interleukin-6 modifies mRNA expression in mouse skeletal muscle
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Interleukin-6 modifies mRNA expression in mouse skeletal muscle. / Hassing, Helle Adser; Wojtaszewski, Jørgen; Jakobsen, Anne Hviid; Kiilerich, Kristian; Hidalgo, J; Pilegaard, Henriette.
In: Acta Physiologica, Vol. 202, No. 2, 2011, p. 165-173.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Interleukin-6 modifies mRNA expression in mouse skeletal muscle
AU - Hassing, Helle Adser
AU - Wojtaszewski, Jørgen
AU - Jakobsen, Anne Hviid
AU - Kiilerich, Kristian
AU - Hidalgo, J
AU - Pilegaard, Henriette
N1 - CURIS 2011 5200 028
PY - 2011
Y1 - 2011
N2 - Aim: The aim of the present study was to test the hypothesis that interleukin-6 plays a role in exercise-induced PGC-1a and TNFa mRNA responses in skeletal muscle and to examine the potential IL-6 mediated AMPK regulation in these responses. Methods: Whole body IL-6 knockout and wildtype (WT) male mice (4 month) performed 1h treadmill exercise. White gastrocnemius (WG) and quadriceps muscles were removed immediately (0') or 4h after exercise and from mice not run acutely. Results: Acute exercise reduced only in WT muscle glycogen concentration to 55% and 35% (P
AB - Aim: The aim of the present study was to test the hypothesis that interleukin-6 plays a role in exercise-induced PGC-1a and TNFa mRNA responses in skeletal muscle and to examine the potential IL-6 mediated AMPK regulation in these responses. Methods: Whole body IL-6 knockout and wildtype (WT) male mice (4 month) performed 1h treadmill exercise. White gastrocnemius (WG) and quadriceps muscles were removed immediately (0') or 4h after exercise and from mice not run acutely. Results: Acute exercise reduced only in WT muscle glycogen concentration to 55% and 35% (P
U2 - 10.1111/j.1748-1716.2011.02269.x
DO - 10.1111/j.1748-1716.2011.02269.x
M3 - Journal article
C2 - 21352507
VL - 202
SP - 165
EP - 173
JO - Acta Physiologica
JF - Acta Physiologica
SN - 1748-1708
IS - 2
ER -
ID: 32928426