The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. / Cano, Amparo; Pérez-Moreno, Mirna A.; Rodrigo, Isabel; Locascio, Annamaria; Blanco, María J.; del Barrio, Marta G.; Portillo, Francisco; Nieto, M. Angela.

In: Nature Cell Biology, Vol. 2, No. 2, 2000, p. 76-83.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cano, A, Pérez-Moreno, MA, Rodrigo, I, Locascio, A, Blanco, MJ, del Barrio, MG, Portillo, F & Nieto, MA 2000, 'The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression', Nature Cell Biology, vol. 2, no. 2, pp. 76-83. https://doi.org/10.1038/35000025

APA

Cano, A., Pérez-Moreno, M. A., Rodrigo, I., Locascio, A., Blanco, M. J., del Barrio, M. G., Portillo, F., & Nieto, M. A. (2000). The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biology, 2(2), 76-83. https://doi.org/10.1038/35000025

Vancouver

Cano A, Pérez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG et al. The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biology. 2000;2(2):76-83. https://doi.org/10.1038/35000025

Author

Cano, Amparo ; Pérez-Moreno, Mirna A. ; Rodrigo, Isabel ; Locascio, Annamaria ; Blanco, María J. ; del Barrio, Marta G. ; Portillo, Francisco ; Nieto, M. Angela. / The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. In: Nature Cell Biology. 2000 ; Vol. 2, No. 2. pp. 76-83.

Bibtex

@article{c5bf51f18ba44775a643c2703bad4156,
title = "The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression",
abstract = "The Snail family of transcription factors has previously been implicated in the differentiation of epithelial cells into mesenchymal cells (epithelial-mesenchymal transitions) during embryonic development. Epithelial-mesenchymal transitions are also determinants of the progression of carcinomas, occurring concomitantly with the cellular acquisition of migratory properties following downregulation of expression of the adhesion protein E-cadherin. Here we show that mouse Snail is a strong repressor of transcription of the E-cadherin gene. Epithelial cells that ectopically express Snail adopt a fibroblastoid phenotype and acquire tumorigenic and invasive properties. Endogenous Snail protein is present in invasive mouse and human carcinoma cell lines and tumours in which E-cadherin expression has been lost. Therefore, the same molecules are used to trigger epithelial-mesenchymal transitions during embryonic development and in tumour progression. Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs.",
keywords = "Animals, Binding Sites, Cadherins, Carcinoma, Carcinoma, Squamous Cell, Cell Differentiation, Cell Movement, Cytoskeletal Proteins, DNA-Binding Proteins, Desmoplakins, Epithelial Cells, Gene Expression Regulation, Developmental, Humans, Keratinocytes, Mesoderm, Mice, Neoplasm Invasiveness, Neoplasms, Glandular and Epithelial, Phenotype, Promoter Regions, Genetic, Protein Binding, Repressor Proteins, Snail Family Transcription Factors, Transcription Factors, Tumor Cells, Cultured, Journal Article, Research Support, Non-U.S. Gov't",
author = "Amparo Cano and P{\'e}rez-Moreno, {Mirna A.} and Isabel Rodrigo and Annamaria Locascio and Blanco, {Mar{\'i}a J.} and {del Barrio}, {Marta G.} and Francisco Portillo and Nieto, {M. Angela}",
year = "2000",
doi = "10.1038/35000025",
language = "English",
volume = "2",
pages = "76--83",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "nature publishing group",
number = "2",

}

RIS

TY - JOUR

T1 - The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

AU - Cano, Amparo

AU - Pérez-Moreno, Mirna A.

AU - Rodrigo, Isabel

AU - Locascio, Annamaria

AU - Blanco, María J.

AU - del Barrio, Marta G.

AU - Portillo, Francisco

AU - Nieto, M. Angela

PY - 2000

Y1 - 2000

N2 - The Snail family of transcription factors has previously been implicated in the differentiation of epithelial cells into mesenchymal cells (epithelial-mesenchymal transitions) during embryonic development. Epithelial-mesenchymal transitions are also determinants of the progression of carcinomas, occurring concomitantly with the cellular acquisition of migratory properties following downregulation of expression of the adhesion protein E-cadherin. Here we show that mouse Snail is a strong repressor of transcription of the E-cadherin gene. Epithelial cells that ectopically express Snail adopt a fibroblastoid phenotype and acquire tumorigenic and invasive properties. Endogenous Snail protein is present in invasive mouse and human carcinoma cell lines and tumours in which E-cadherin expression has been lost. Therefore, the same molecules are used to trigger epithelial-mesenchymal transitions during embryonic development and in tumour progression. Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs.

AB - The Snail family of transcription factors has previously been implicated in the differentiation of epithelial cells into mesenchymal cells (epithelial-mesenchymal transitions) during embryonic development. Epithelial-mesenchymal transitions are also determinants of the progression of carcinomas, occurring concomitantly with the cellular acquisition of migratory properties following downregulation of expression of the adhesion protein E-cadherin. Here we show that mouse Snail is a strong repressor of transcription of the E-cadherin gene. Epithelial cells that ectopically express Snail adopt a fibroblastoid phenotype and acquire tumorigenic and invasive properties. Endogenous Snail protein is present in invasive mouse and human carcinoma cell lines and tumours in which E-cadherin expression has been lost. Therefore, the same molecules are used to trigger epithelial-mesenchymal transitions during embryonic development and in tumour progression. Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs.

KW - Animals

KW - Binding Sites

KW - Cadherins

KW - Carcinoma

KW - Carcinoma, Squamous Cell

KW - Cell Differentiation

KW - Cell Movement

KW - Cytoskeletal Proteins

KW - DNA-Binding Proteins

KW - Desmoplakins

KW - Epithelial Cells

KW - Gene Expression Regulation, Developmental

KW - Humans

KW - Keratinocytes

KW - Mesoderm

KW - Mice

KW - Neoplasm Invasiveness

KW - Neoplasms, Glandular and Epithelial

KW - Phenotype

KW - Promoter Regions, Genetic

KW - Protein Binding

KW - Repressor Proteins

KW - Snail Family Transcription Factors

KW - Transcription Factors

KW - Tumor Cells, Cultured

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/35000025

DO - 10.1038/35000025

M3 - Journal article

C2 - 10655586

VL - 2

SP - 76

EP - 83

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 2

ER -

ID: 188406998