Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat. / Hidalgo, Juan; Florit, Sergi; Giralt, Mercedes; Ferrer, Beatriz; Keller, Charlotte; Pilegaard, Henriette.

In: Brain, Behavior, and Immunity, Vol. 24, No. 1, 2010, p. 119-26.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hidalgo, J, Florit, S, Giralt, M, Ferrer, B, Keller, C & Pilegaard, H 2010, 'Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat', Brain, Behavior, and Immunity, vol. 24, no. 1, pp. 119-26. https://doi.org/10.1016/j.bbi.2009.09.002

APA

Hidalgo, J., Florit, S., Giralt, M., Ferrer, B., Keller, C., & Pilegaard, H. (2010). Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat. Brain, Behavior, and Immunity, 24(1), 119-26. https://doi.org/10.1016/j.bbi.2009.09.002

Vancouver

Hidalgo J, Florit S, Giralt M, Ferrer B, Keller C, Pilegaard H. Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat. Brain, Behavior, and Immunity. 2010;24(1):119-26. https://doi.org/10.1016/j.bbi.2009.09.002

Author

Hidalgo, Juan ; Florit, Sergi ; Giralt, Mercedes ; Ferrer, Beatriz ; Keller, Charlotte ; Pilegaard, Henriette. / Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat. In: Brain, Behavior, and Immunity. 2010 ; Vol. 24, No. 1. pp. 119-26.

Bibtex

@article{8b51b950277511df8ed1000ea68e967b,
title = "Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat",
abstract = "Interleukin-6 (IL-6) is a major cytokine involved in both normal physiological brain functions and underlying significant neuropathology. IL-6 has been suggested to play a role in the control of body weight but the results are somewhat controversial. In this study we have challenged transgenic mice with astrocyte-targeted IL-6 expression (GFAP-IL6 mice) with a high-fat diet (55% kcal from fat) versus a control diet (10%). The results demonstrate that the GFAP-IL6 mice are resistant to high-fat diet-induced increases in body weight and body fat, apparently without altering food intake and with no evidences of increased sympathetic tone. The high-fat diet-induced impaired responses to an insulin tolerance test (ITT), and to an oral glucose tolerance test (OGTT) in both genotypes. The GFAP-IL6 mice did not differ from littermate wild-type (WT) mice in ITT, but they were more glucose intolerant following the high-fat diet feeding. In summary, the present results demonstrate that brain-specific IL-6 controls body weight which may be a significant factor in physiological conditions and/or in diseases causing neuroinflammation.",
author = "Juan Hidalgo and Sergi Florit and Mercedes Giralt and Beatriz Ferrer and Charlotte Keller and Henriette Pilegaard",
note = "Keywords: Adiposity; Animals; Astrocytes; Body Composition; Body Weight; Cold Temperature; Diet; Dietary Fats; Female; Glial Fibrillary Acidic Protein; Glucose Tolerance Test; Hypothalamus; Insulin; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Promoter Regions, Genetic; RNA; Reverse Transcriptase Polymerase Chain Reaction; Sex Characteristics; Stress, Psychological",
year = "2010",
doi = "10.1016/j.bbi.2009.09.002",
language = "English",
volume = "24",
pages = "119--26",
journal = "Brain, Behavior, and Immunity",
issn = "0889-1591",
publisher = "Academic Press",
number = "1",

}

RIS

TY - JOUR

T1 - Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat

AU - Hidalgo, Juan

AU - Florit, Sergi

AU - Giralt, Mercedes

AU - Ferrer, Beatriz

AU - Keller, Charlotte

AU - Pilegaard, Henriette

N1 - Keywords: Adiposity; Animals; Astrocytes; Body Composition; Body Weight; Cold Temperature; Diet; Dietary Fats; Female; Glial Fibrillary Acidic Protein; Glucose Tolerance Test; Hypothalamus; Insulin; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Promoter Regions, Genetic; RNA; Reverse Transcriptase Polymerase Chain Reaction; Sex Characteristics; Stress, Psychological

PY - 2010

Y1 - 2010

N2 - Interleukin-6 (IL-6) is a major cytokine involved in both normal physiological brain functions and underlying significant neuropathology. IL-6 has been suggested to play a role in the control of body weight but the results are somewhat controversial. In this study we have challenged transgenic mice with astrocyte-targeted IL-6 expression (GFAP-IL6 mice) with a high-fat diet (55% kcal from fat) versus a control diet (10%). The results demonstrate that the GFAP-IL6 mice are resistant to high-fat diet-induced increases in body weight and body fat, apparently without altering food intake and with no evidences of increased sympathetic tone. The high-fat diet-induced impaired responses to an insulin tolerance test (ITT), and to an oral glucose tolerance test (OGTT) in both genotypes. The GFAP-IL6 mice did not differ from littermate wild-type (WT) mice in ITT, but they were more glucose intolerant following the high-fat diet feeding. In summary, the present results demonstrate that brain-specific IL-6 controls body weight which may be a significant factor in physiological conditions and/or in diseases causing neuroinflammation.

AB - Interleukin-6 (IL-6) is a major cytokine involved in both normal physiological brain functions and underlying significant neuropathology. IL-6 has been suggested to play a role in the control of body weight but the results are somewhat controversial. In this study we have challenged transgenic mice with astrocyte-targeted IL-6 expression (GFAP-IL6 mice) with a high-fat diet (55% kcal from fat) versus a control diet (10%). The results demonstrate that the GFAP-IL6 mice are resistant to high-fat diet-induced increases in body weight and body fat, apparently without altering food intake and with no evidences of increased sympathetic tone. The high-fat diet-induced impaired responses to an insulin tolerance test (ITT), and to an oral glucose tolerance test (OGTT) in both genotypes. The GFAP-IL6 mice did not differ from littermate wild-type (WT) mice in ITT, but they were more glucose intolerant following the high-fat diet feeding. In summary, the present results demonstrate that brain-specific IL-6 controls body weight which may be a significant factor in physiological conditions and/or in diseases causing neuroinflammation.

U2 - 10.1016/j.bbi.2009.09.002

DO - 10.1016/j.bbi.2009.09.002

M3 - Journal article

C2 - 19748567

VL - 24

SP - 119

EP - 126

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

SN - 0889-1591

IS - 1

ER -

ID: 18364728