Bacterial chromosomes and their replication
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
This chapter reviews the current knowledge on the organization and replication of bacterial genomes with a special emphasis on the initiation of DNA replication. Most bacteria contain one chromosome, however a few species, like the human pathogen Vibrio cholerae, carry a secondary chromosome. We discuss structures of origins of replication, the function of initiator proteins, the cell cycle regulation of initiation of replication, and the loading and assembly of replisomes. This is predominantly described for Escherichia coli, but parallels are drawn to Bacillus subtilis along with important pathogenic bacteria when relevant.
Original language | English |
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Title of host publication | Molecular Medical Microbiology |
Editors | Yi-Wei Tang, Musa Y. Hindiyeh, Dongyou Liu, Andrew Sails, Paul Spearman, Jing-Ren Zhang |
Number of pages | 29 |
Volume | 1 |
Publisher | Academic Press |
Publication date | 2024 |
Edition | 3 |
Pages | 279-307 |
Chapter | 14 |
ISBN (Print) | 978-0-12-818610-0 |
ISBN (Electronic) | 9780128186190 |
DOIs | |
Publication status | Published - 2024 |
- chromosome replication during infection, Chromosome structure, global chromosome organization, origin structure, regulation of replication initiation, replication of chromids, replisome structure and dynamics, the bacterial cell cycle
Research areas
ID: 374456454