Kresten Lindorff-Larsen
Professor
Biomolecular Sciences
Ole Maaløes Vej 5
2200 København N.
- 2024
- Published
A mutational atlas for Parkin proteostasis
Clausen, L., Voutsinos, Vasileios, Cagiada, Matteo, Johansson, Kristoffer Enøe, Grønbæk-Thygesen, Martin, Nariya, S., Powell, R. L., Have, M. K. N., Østergaard, Vibe Hallundbæk, Stein, Amelie, Fowler, D. M., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2024, In: Nature Communications. 15, 1, 17 p., 1541.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay
Gersing, S., Schulze, Thea Klarsø, Cagiada, Matteo, Stein, Amelie, Roth, F. P., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2024, In: Genome Biology. 25, 1, 22 p., 98.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational ensembles of the human intrinsically disordered proteome
Tesei, Giulio, Trolle, A. I., Jonsson, Nicolas, Betz, J., Knudsen, F. E., Pesce, Francesco, Johansson, Kristoffer Enøe & Lindorff-Larsen, Kresten, 2024, In: Nature. 626, p. 897-904 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FRETpredict: a Python package for FRET efficiency predictions using rotamer libraries
Montepietra, D., Tesei, Giulio, Martins, J. M., Kunze, M. B. A., Best, R. B. & Lindorff-Larsen, Kresten, 2024, In: Communications Biology . 7, 1, 10 p., 298.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GMMA Can Stabilize Proteins Across Different Functional Constraints
Daffern, N., Johansson, Kristoffer Enøe, Baumer, Z. T., Robertson, N. R., Woojuh, J., Bedewitz, M. A., Davis, Z., Wheeldon, I., Cutler, S. R., Lindorff-Larsen, Kresten & Whitehead, T. A., 2024, In: Journal of Molecular Biology. 436, 11, 15 p., 168586.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Fitting Force Field Parameters to NMR Relaxation Data
Kümmerer, Felix, Orioli, S. & Lindorff-Larsen, Kresten, 5 Jun 2023, In: Journal of Chemical Theory and Computation. 19, 12, p. 3741-3751 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A comprehensive map of human glucokinase variant activity
Gersing, S., Cagiada, Matteo, Gebbia, M., Gjesing, A. P., Coté, A. G., Seesankar, G., Li, R., Tabet, D., Weile, J., Stein, Amelie, Gloyn, A. L., Hansen, Torben, Roth, F. P., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Genome Biology. 24, 1, 23 p., 97.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Accurate protein stability predictions from homology models
Valanciute, A., Nygaard, L., Zschach, Henrike, Maglegaard Jepsen, M., Lindorff-Larsen, Kresten & Stein, Amelie, 2023, In: Computational and Structural Biotechnology Journal. 21, p. 66-73 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation and substrate specificity of the human P4-ATPase ATP8B1
Dieudonné, T., Kümmerer, Felix, Laursen, M. J., Stock, C., Flygaard, R. K., Khalid, S., Lenoir, G., Lyons, J. A., Lindorff-Larsen, Kresten & Nissen, P., 2023, In: Nature Communications. 14, 1, 14 p., 7492.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins
Pesce, Francesco, Newcombe, Estella Anne, Seiffert, P., Tranchant, E. E., Olsen, Johan Gotthardt, Grace, C. R., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2023, In: Biophysical Journal. 122, 2, p. 310-321 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combining Experiments and Simulations to Examine the Temperature-Dependent Behavior of a Disordered Protein
Pesce, Francesco & Lindorff-Larsen, Kresten, 2023, In: Journal of Physical Chemistry B. 127, 28, p. 6277-6286 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations
Thomasen, Emil, Cuneo, M. J., Mittag, T. & Lindorff-Larsen, Kresten, 2023, In: eLife. 12, 23 p., e84147.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovering functionally important sites in proteins
Cagiada, Matteo, Bottaro, S., Lindemose, Søren, Schenstrøm, S. M., Stein, Amelie, Hartmann-Petersen, Rasmus & Lindorff-Larsen, Kresten, 2023, In: Nature Communications. 14, 1, 13 p., 4175.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Folding of heterologous proteins in bacterial cell factories: Cellular mechanisms and engineering strategies
Rong, Y., Jensen, S. I., Lindorff-Larsen, Kresten & Nielsen, A. T., 2023, In: Biotechnology Advances. 63, 21 p., 108079.Research output: Contribution to journal › Review › Research › peer-review
- Published
Global analysis of multi-mutants to improve protein function
Johansson, Kristoffer Enøe, Lindorff-Larsen, Kresten & Winther, Jakob R., 2023, In: Journal of Molecular Biology. 435, 8, 15 p., 168034.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HSP70-binding motifs function as protein quality control degrons
Abildgaard, A. B., Voutsinos, Vasileios, Petersen, S. D., Larsen, Fia Brunsgaard Valsted, Kampmeyer, Caroline, Johansson, Kristoffer Enøe, Stein, Amelie, Ravid, T., Andréasson, C., Jensen, M. K., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Cellular and Molecular Life Sciences. 80, 1, 17 p., 32.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improved predictions of phase behaviour of intrinsically disordered proteins by tuning the interaction range
Tesei, Giulio & Lindorff-Larsen, Kresten, 2023, In: Open Research Europe. 2, 94, 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insights into the conservation and diversification of the molecular functions of YTHDF proteins
Flores-Téllez, D., Tankmar, Mathias Due, von Bülow, Sören, Chen, Junyu, Lindorff-Larsen, Kresten, Brodersen, Peter & Arribas Hernandez, Laura, 2023, In: PLOS Genetics. 19, 10, 37 p., e1010980.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrated NMR/Molecular Dynamics Determination of the Ensemble Conformation of a Thermodynamically Stable CUUG RNA Tetraloop
Oxenfarth, A., Kümmerer, Felix, Bottaro, S., Schnieders, R., Pinter, G., Jonker, H. R. A., Fürtig, B., Richter, C., Blackledge, M., Lindorff-Larsen, Kresten & Schwalbe, H., 2023, In: Journal of the American Chemical Society. 145, 30, p. 16557-16572 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interpreting the molecular mechanisms of disease variants in human transmembrane proteins
Tiemann, Johanna Katarina Sofie, Zschach, Henrike, Lindorff-Larsen, Kresten & Stein, Amelie, 2023, In: Biophysical Journal. 122, 11, 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lynch syndrome, molecular mechanisms and variant classification
Abildgaard, A. B., Nielsen, S., Bernstein, I., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: British Journal of Cancer. 128, 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6-methyladenosine-containing RNA virus
Martínez-Pérez, M., Aparicio, F., Arribas Hernandez, Laura, Tankmar, Mathias Due, Rennie, Sarah, von Bülow, Sören, Lindorff-Larsen, Kresten, Brodersen, Peter & Pallas, V., 2023, In: EMBO Journal. 42, 18, 17 p., e113378.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Prediction of Quality-control Degradation Signals in Yeast Proteins
Johansson, Kristoffer Enøe, Mashahreh, B., Hartmann-Petersen, Rasmus, Ravid, T. & Lindorff-Larsen, Kresten, 2023, In: Journal of Molecular Biology. 435, 2, 9 p., 167915.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rapid protein stability prediction using deep learning representations
Blaabjerg, Lasse Møller, Kassem, M. M., Good, L. L., Jonsson, Nicolas, Cagiada, Matteo, Johansson, Kristoffer Enøe, Boomsma, Wouter, Stein, Amelie & Lindorff-Larsen, Kresten, 2023, In: eLife. 12, 19 p., e82593.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rare Catechol-O-methyltransferase Missense Variants Are Structurally Unstable Proteasome Targets
Larsen, Fia Brunsgaard Valsted, Cagiada, Matteo, Dideriksen, J., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2023, In: Biochemistry. 62, 8, 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Slow conformational changes in the rigid and highly stable chymotrypsin inhibitor 2
Gavrilov, Y., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2023, In: Protein Science. 32, 4, 9 p., 4604.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of linker conformation on performance and stability of a two-domain lytic polysaccharide monooxygenase
Forsberg, Z., Stepnov, A. A., Tesei, Giulio, Wang, Y., Buchinger, E., Kristiansen, S. K., Aachmann, F. L., Arleth, Lise, Eijsink, V. G. H., Lindorff-Larsen, Kresten & Courtade, G., 2023, In: Journal of Biological Chemistry. 299, 11, 17 p., 105262.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate
Araya-Secchi, R., Bugge, K., Seiffert, P., Petry, A., Haxholm, G. W., Lindorff-Larsen, Kresten, Pedersen, Stine Helene Falsig, Arleth, Lise & Kragelund, Birthe Brandt, 2023, In: eLife. 12, 27 p., e84645.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation
Chhabra, Y., Seiffert, P., Gormal, R. S., Vullings, M., Lee, C. M. M., Wallis, T. P., Dehkhoda, F., Indrakumar, S., Jacobsen, Nina Louise, Lindorff-Larsen, Kresten, Durisic, N., Waters, M. J., Meunier, F. A., Kragelund, Birthe Brandt & Brooks, A. J., 2023, In: Cell Reports. 42, 5, 26 p., 112490.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
WASCO: A Wasserstein-based Statistical Tool to Compare Conformational Ensembles of Intrinsically Disordered Proteins
González-Delgado, J., Sagar, A., Zanon, C., Lindorff-Larsen, Kresten, Bernadó, P., Neuvial, P. & Cortés, J., 2023, In: Journal of Molecular Biology. 435, 14, 11 p., 168053.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes
Gjesing, A. P., Engelbrechtsen, L., Cathrine B. Thuesen, A., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Steen Nielsen, J., Christensen, L. B., Thomsen, R. W., Johansson, K. E., Cagiada, M., Gersing, S., Hartmann-Petersen, R., Lindorff-Larsen, K., Vaag, A., Sørensen, H. T., Brandslund, I., Beck-Nielsen, H., Pedersen, O. & 2 others, , 2022, In: Diabetes Research and Clinical Practice. 194, 9 p., 110159.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A structural biology community assessment of AlphaFold2 applications
Akdel, M., Pires, D. E., Porta Pardo, E., Jänes, J., Zalevsky, A. O., Meszaros, B., Bryant, P., Good, L. L., Laskowski, R. A., Pozzati, G., Shenoy, A., Zhu, W., Kundrotas, P., Serra, V. R., Rodrigues, C. H. M., Dunham, A. S., Burke, D., Borkakoti, N., Velankar, S., Frost, A. & 14 others, , 2022, In: Nature Structural & Molecular Biology. 29, 11, 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system
Koivisto, J. M., Poulsen, N. R., Larsen, B. S., Weibull, M. G. M., Stein, Amelie, Doro, F., Winther, Jakob R., Lindorff-Larsen, Kresten & Willemoës, Martin, 2022, In: The Biochemical journal. 479, 4, p. 479-501Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins
Thomasen, Emil & Lindorff-Larsen, Kresten, 2022, In: Biochemical Society Transactions. 50, 1, p. 541-554 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Conserved conformational dynamics determine enzyme activity
Torgeson, K. R., Clarkson, M. W., Granata, D., Lindorff-Larsen, Kresten, Page, R. & Peti, W., 2022, In: Science Advances. 8, 31, 10 p., eabo5546.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conserved degronome features governing quality control associated proteolysis
Mashahreh, B., Armony, S., Johansson, Kristoffer Enøe, Chappleboim, A., Friedman, N., Gardner, R. G., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Ravid, T., 2022, In: Nature Communications. 13, 1, 13 p., 7588.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity
Neumann, C., Rosenbæk, L. L., Flygaard, R. K., Habeck, M., Karlsen, J. L., Wang, Y., Lindorff-Larsen, Kresten, Gad, H. H., Hartmann, R., Lyons, J. A., Fenton, R. A. & Nissen, P., 2022, In: EMBO Journal. 41, 23, 15 p., e110169.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deciphering the Alphabet of Disorder-Glu and Asp Act Differently on Local but Not Global Properties
Roesgaard, M. A., Lundsgaard, J. E., Newcombe, Estella Anne, Jacobsen, Nina Louise, Pesce, Francesco, Tranchant, E. E., Lindemose, Søren, Prestel, Andreas, Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2022, In: Biomolecules. 12, 10, 19 p., 1426.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disease-linked mutations cause exposure of a protein quality control degron
Kampmeyer, Caroline, Larsen-Ledet, Sven, Wagnkilde, M. R., Michelsen, M., Iversen, Henriette Kring Mangor, Nielsen, S. V., Lindemose, Søren, Caregnato, A., Ravid, T., Stein, Amelie, Teilum, Kaare, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2022, In: Structure. 30, 9, p. 1245-1253.e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Double Mutant of Chymotrypsin Inhibitor 2 Stabilized through Increased Conformational Entropy
Gavrilov, Y., Kümmerer, Felix, Orioli, S., Prestel, Andreas, Lindorff-Larsen, Kresten & Teilum, Kaare, 2022, In: Biochemistry. 61, 3, p. 160-170 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation
Pacheco-Garcia, J. L., Cagiada, Matteo, Tienne-Matos, K., Salido, E., Lindorff-Larsen, Kresten & L. Pey, A., 2022, In: Frontiers in Molecular Biosciences. 9, 17 p., 1063620.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein
Gaggero, S., Martinez-Fabregas, J., Cozzani, A., Fyfe, P. K., Leprohon, M., Yang, J., Thomasen, F. E., Winkelmann, H., Magnez, R., Conti, A. G., Wilmes, S., Pohler, E., van Gijsel Bonnello, M., Thuru, X., Quesnel, B., Soncin, F., Piehler, J., Lindorff-Larsen, K., Roychoudhuri, R., Moraga, I. & 1 others, , 2022, In: Science immunology. 7, 78, 15 p., eade5686.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improving Martini 3 for Disordered and Multidomain Proteins
Thomasen, Emil, Pesce, Francesco, Roesgaard, M. A., Tesei, Giulio & Lindorff-Larsen, Kresten, 2022, In: Journal of Chemical Theory and Computation. 18, 4, p. 2033-2041 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increasing protein stability by inferring substitution effects from high-throughput experiments
Norrild, R. K., Johansson, Kristoffer Enøe, O'Shea, Charlotte, Morth, J. P., Lindorff-Larsen, Kresten & Winther, Jakob R., 2022, In: Cell Reports Methods. 2, 11, 11 p., 100333.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation
Johansen, Nicolai Tidemand, Bonaccorsi, M., Bengtsen, T., Nørgrd Larsen, Andreas, Tidemand, Frederik Grønbæk, Pedersen, Martin Cramer, Huda, P., Berndtsson, J., Darwish, T., Yepuri, N. R., Martel, A., Pomorski, Thomas Guenther, Bertarello, A., Sansom, M., Rapp, M., Crehuet, R., Schubeis, T., Lindorff-Larsen, Kresten, Pintacuda, G. & Arleth, Lise, 2022, In: eLife. 11, 35 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation
Høie, M. H., Cagiada, Matteo, Frederiksen, A. H. B., Stein, Amelie & Lindorff-Larsen, Kresten, 2022, In: Cell Reports. 38, 2, 15 p., 110207.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21
Svenningsen, E. B., Ottosen, R. N., Jørgensen, K. H., Nisavic, M., Larsen, C. K., Hansen, B. K., Wang, Y., Lindorff-Larsen, Kresten, Tørring, T., Hacker, S. M., Palmfeldt, J. & Poulsen, T. B., 2022, In: RSC Chemical Biology. 3, 10, p. 1216-1229 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of water coordination in the pH-dependent gating of hAQP10
Truelsen, S. F., Missel, Julie Winkel, Gotfryd, K., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel, Lindorff-Larsen, Kresten & Hélix-Nielsen, C., 2022, In: B B A - Biomembranes. 1864, 1, 13 p., 183809.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transient exposure of a buried phosphorylation site in an autoinhibited protein
Orioli, S., Henning Hansen, C. G. & Lindorff-Larsen, Kresten, 2022, In: Biophysical Journal. 121, 1, p. 91-101 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
VM i molekylære puslespil
Abildgaard, A. B., Winther, Jakob R., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 16 Apr 2021, In: Weekendavisen: Ideer. 15, p. 11Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
- Published
Molekylære stavefejl
Abildgaard, A. B., Winther, Jakob R., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 28 Jan 2021, In: Weekendavisen, Ideer.Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
- Published
A dual-reporter system for investigating and optimizing protein translation and folding in E. coli
Zutz, A., Hamborg, L., Pedersen, L. E., Kassem, M. M., Papaleo, E., Koza, A., Herrgård, M. J., Ingemann Jensen, S., Teilum, Kaare, Lindorff-Larsen, Kresten & Nielsen, A. T., 2021, In: Nature Communications. 12, 15 p., 6093.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Accurate model of liquid-liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties
Tesei, Giulio, Schulze, T. K., Crehuet, R. & Lindorff-Larsen, Kresten, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 44, 10 p., e2111696118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Architecture and assembly dynamics of the essential mitochondrial chaperone complex TIM9·10·12
Weinhäupl, K., Wang, Y., Hessel, A., Brennich, M., Lindorff-Larsen, Kresten & Schanda, P., 2021, In: Structure. 29, 9, p. 1065-1073.e4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Charge Interactions in a Highly Charge-Depleted Protein
Hervø-Hansen, S., Højgaard, C., Johansson, Kristoffer Enøe, Wang, Y., Wahni, K., Young, D., Messens, J., Teilum, Kaare, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: Journal of the American Chemical Society. 143, 6, p. 2500-2508 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computational and Experimental Assessment of Backbone Templates for Computational Redesign of the Thioredoxin Fold
Marin, Frederikke Isa, Johansson, Kristoffer Enøe, O'Shea, Charlotte, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: The Journal of Physical Chemistry B. 125, 40, p. 11141-11149Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
Conformational Ensembles of Noncoding Elements in the SARS-CoV-2 Genome from Molecular Dynamics Simulations
Bottaro, S., Bussi, G. & Lindorff-Larsen, Kresten, 2021, In: Journal of the American Chemical Society. 143, 22, p. 8333-8343Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Y., Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DEER-PREdict: Software for efficient calculation of spin-labeling EPR and NMR data from conformational ensembles
Tesei, Giulio, Martins, J. M., Kunze, M. B. A., Wang, Y., Crehuet, R. & Lindorff-Larsen, Kresten, 2021, In: PLOS Computational Biology. 17, 1, 18 p., e1008551.Research output: Contribution to journal › Journal article › Research › peer-review
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Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks
Koehler Leman, J., Lyskov, S., Lewis, S. M., Adolf-Bryfogle, J., Alford, R. F., Barlow, K., Ben-Aharon, Z., Farrell, D., Fell, J., Hansen, W. A., Harmalkar, A., Jeliazkov, J., Kuenze, G., Krys, J. D., Ljubetič, A., Loshbaugh, A. L., Maguire, J., Moretti, R., Mulligan, V. K., Nance, M. L. & 30 others, , 2021, In: Nature Communications. 12, 15 p., 6947.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fitting Side-Chain NMR Relaxation Data Using Molecular Simulations
Kümmerer, Felix, Orioli, S., Harding-Larsen, D., Hoffmann, F., Gavrilov, Y., Teilum, Kaare & Lindorff-Larsen, Kresten, 2021, In: Journal of Chemical Theory and Computation. 17, 8, p. 5262-5275 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Force Field Effects in Simulations of Flexible Peptides with Varying Polyproline II Propensity
Jephthah, S., Pesce, Francesco, Lindorff-Larsen, Kresten & Skepö, M., 2021, In: Journal of Chemical Theory and Computation. 17, 10, p. 6634-6646 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins
Newcombe, Estella Anne, Fernandes, Catarina, Lundsgaard, J. E., Brakti, Inna, Lindorff-Larsen, Kresten, Langkilde, Annette Eva, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Biomolecules. 11, 8, 17 p., 1173.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
Martin, E. W., Thomasen, Emil, Milkovic, N. M., Cuneo, M. J., Grace, C. R., Nourse, A., Lindorff-Larsen, Kresten & Mittag, T., 2021, In: Nucleic Acids Research. 49, 5, p. 2931-2945 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Linking thermodynamics and measurements of protein stability
Lindorff-Larsen, Kresten & Teilum, Kaare, 2021, In: Protein engineering, design & selection : PEDS. 34, 13 p., gzab002.Research output: Contribution to journal › Review › Research › peer-review
- Published
Mapping the degradation pathway of a disease-linked aspartoacylase variant
Gersing, S. K., Wang, Y., Grønbæk-Thygesen, Martin, Kampmeyer, Caroline, Bjørnkjær, Lene, Willemoës, Martin, Andréasson, C., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2021, In: PLOS Genetics. 17, 4, 28 p., e1009539.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiplexed assays reveal effects of missense variants in MSH2 and cancer predisposition
Nielsen, S. V., Hartmann-Petersen, Rasmus, Stein, Amelie & Lindorff-Larsen, Kresten, 2021, In: PLOS Genetics. 17, 4, 6 p., e1009496.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the Potential of Machine Learning to Examine the Relationship Between Sequence, Structure, Dynamics and Function of Intrinsically Disordered Proteins
Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2021, In: Journal of Molecular Biology. 433, 20, 22 p., 167196.Research output: Contribution to journal › Review › Research › peer-review
- Published
Order and disorder - An integrative structure of the full-length human growth hormone receptor
Kassem, N., Araya-Secchi, R., Bugge, K., Barclay, A., Steinocher, H., Khondker, A., Wang, Y., Lenard, A. J., Bürck, J., Sahin, Cagla, Ulrich, A. S., Landreh, M., Pedersen, Martin Cramer, Rheinstädter, M. C., Pedersen, Per Amstrup, Lindorff-Larsen, Kresten, Arleth, Lise & Kragelund, Birthe Brandt, 2021, In: Science Advances. 7, 27, 20 p., eabh3805.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Properdin oligomers adopt rigid extended conformations supporting function
Pedersen, D. V., Pedersen, M. N., Mazarakis, S. M. M., Wang, Y., Lindorff-Larsen, Kresten, Arleth, Lise & Andersen, G. R., 2021, In: eLife. 10, 22 p., e63356.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods
Ahmed, M. C., Skaanning, L. K., Jussupow, A., Newcombe, Estella Anne, Kragelund, Birthe Brandt, Camilloni, C., Langkilde, Annette Eva & Lindorff-Larsen, Kresten, 2021, In: Frontiers in Molecular Biosciences. 8, 13 p., 654333.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Refining conformational ensembles of flexible proteins against small-angle x-ray scattering data
Pesce, Francesco & Lindorff-Larsen, Kresten, 2021, In: Biophysical Journal. 120, 22, p. 5124-5135 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and functional variation of chitin-binding domains of a lytic polysaccharide monooxygenase from Cellvibrio japonicus
Madland, E., Forsberg, Z., Wang, Y., Lindorff-Larsen, Kresten, Niebisch, A., Modregger, J., Eijsink, V. G. H., Aachmann, F. L. & Courtade, G., 2021, In: Journal of Biological Chemistry. 297, 4, 17 p., 101084.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli
Hamborg, L., Granata, D., Olsen, Johan Gotthardt, Roche, J. V., Pedersen, L. E., Nielsen, A. T., Lindorff-Larsen, Kresten & Teilum, Kaare, 2021, In: Communications Biology . 4, 9 p., 980.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs
Lambrughi, M., Maiani, E., Fas, B. A., Shaw, G. S., Kragelund, Birthe Brandt, Lindorff-Larsen, Kresten, Teilum, Kaare, Invernizzi, G. & Papaleo, E., 2021, In: Frontiers in Molecular Biosciences. 8, 14 p., 676235.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance
Cagiada, Matteo, Johansson, Kristoffer Enøe, Valanciute, A., Nielsen, S. V., Hartmann-Petersen, Rasmus, Yang, J. J., Fowler, D. M., Stein, Amelie & Lindorff-Larsen, Kresten, 2021, In: Molecular Biology and Evolution. 38, 8, p. 3235-3246Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations.
Bengtsen, T., Midtgaard, S. R., Holm-Janas, Viktor, Kjølbye, L. R., Johansen, Nicolai Tidemand, Tesei, Giulio, Bottaro, S., Schiøtt, B., Arleth, Lise & Lindorff-Larsen, Kresten, 30 Jul 2020, In: eLife. 9, 24 p., e56518.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Small-angle Neutron Scattering Shows that the Solution Structures of the Bacterial Mg2+-Channel CorA are Overall Similar with and without Mg2+ Bound
Arleth, Lise, Johansen, Nicolai Tidemand, Bengtsen, T., Larsen, A. H., Tidemand, Frederik Grønbæk, Pomorski, Thomas Guenther & Lindorff-Larsen, Kresten, 7 Feb 2020, In: Biophysical Journal. 118, 3, Suppl. 1, p. 12A 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Classifying disease-associated variants using measures of protein activity and stability
Jepsen, M. M., Fowler, D. M., Hartmann-Petersen, Rasmus, Stein, Amelie & Lindorff-Larsen, Kresten, 2020, Protein Homeostasis Diseases: Mechanisms and Novel Therapies. Pey, A. L. (ed.). Elsevier, p. 91-107Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome
Abildgaard, A. B., Gersing, S. K., Larsen-Ledet, Sven, Nielsen, S. V., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, In: Biomolecules. 10, 8, 24 p., 1141.Research output: Contribution to journal › Review › Research › peer-review
- Published
Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution
Nørgrd Larsen, Andreas, Wang, Y., Bottaro, S., Grudinin, S., Arleth, Lise & Lindorff-Larsen, Kresten, 2020, In: P L o S Computational Biology. 16, 4, 29 p., e1007870.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computing, Analyzing, and Comparing the Radius of Gyration and Hydrodynamic Radius in Conformational Ensembles of Intrinsically Disordered Proteins
Ahmed, M. C., Crehuet, R. & Lindorff-Larsen, Kresten, 2020, Intrinsically Disordered Proteins: Methods and Protocols. Kragelund, B. B. & Skriver, K. (eds.). Humana Press, p. 429-445 17 p. (Methods in Molecular Biology, Vol. 2141).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation
Bjørnkjær, Lene, Stein, Amelie, Grønbæk-Thygesen, Martin, Nygaard, L., Søltoft, C. L., Nielsen, S. V., Lisby, Michael, Ravid, T., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, In: PLOS Genetics. 16, 11, 28 p., e1009187.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Global analysis of protein stability by temperature and chemical denaturation
Hamborg, L., Horsted, E. W., Johansson, Kristoffer Enøe, Willemoës, Martin, Lindorff-Larsen, Kresten & Teilum, Kaare, 2020, In: Analytical Biochemistry. 605, 7 p., 113863.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How to learn from inconsistencies: Integrating molecular simulations with experimental data
Orioli, S., Nørgrd Larsen, Andreas, Bottaro, S. & Lindorff-Larsen, Kresten, 2020, Computational Approaches for Understanding Dynamical Systems: Protein Folding and Assembly. Strodel, B. & Barz, B. (eds.). Academic Press, p. 123-176 54 p. (Progress in Molecular Biology and Translational Science, Vol. 170).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Integrating Molecular Simulation and Experimental Data: A Bayesian/Maximum Entropy Reweighting Approach
Bottaro, S., Bengtsen, T. & Lindorff-Larsen, Kresten, 2020, Structural Bioinformatics: Methods and Protocols. Gáspári, Z. (ed.). Humana Press, p. 219-240 22 p. (Methods in Molecular Biology, Vol. 2112).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Integrating NMR and simulations reveals motions in the UUCG tetraloop
Bottaro, S., Nichols, P. J., Vögeli, B., Parrinello, M. & Lindorff-Larsen, Kresten, 2020, In: Nucleic Acids Research. 48, 11, p. 5839-5848 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel HARS2 missense variants identified in individuals with sensorineural hearing impairment and Perrault syndrome
Karstensen, H. G., Rendtorff, N. D., Hindbæk, L. S., Colombo, R., Stein, Amelie, Birkebæk, N. H., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten, Højland, A. T., Petersen, M. B. & Tranebjærg, Lisbeth, 2020, In: European Journal of Medical Genetics. 63, 3, 6 p., 103733.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein Dynamics Enables Phosphorylation of Buried Residues in Cdk2/Cyclin-A-Bound p27
Henriques, J. & Lindorff-Larsen, Kresten, 2020, In: Biophysical Journal. 119, 10, p. 2010-2018 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein destabilization and degradation as a mechanism for hereditary disease
Nielsen, S. V., Schenstrøm, S. M., Christensen, Caspar Elo, Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2020, Protein Homeostasis Diseases: Mechanisms and Novel Therapies. Pey, A. L. (ed.). Elsevier, p. 111-125Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Structural basis of client specificity in mitochondrial membrane-protein chaperones
Sučec, I., Wang, Y., Dakhlaoui, O., Weinhäupl, K., Jores, T., Costa, D., Hessel, A., Brennich, M., Rapaport, D., Lindorff-Larsen, Kresten, Bersch, B. & Schanda, P., 2020, In: Science Advances. 6, 51, 15 p., eabd0263.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
What Will Computational Modeling Approaches Have to Say in the Era of Atomistic Cryo-EM Data?
Fraser, J. S., Lindorff-Larsen, Kresten & Bonomi, M., 2020, In: Journal of Chemical Information and Modeling. 60, 5, p. 2410-2412 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- 2019
- Published
Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
Lückmann, Michael, Trauelsen, Mette, Bentsen, M. A., Nissen, T. A. D., Martins, J., Fallah, Z., Nygaard, M. M., Papaleo, E., Lindorff-Larsen, Kresten, Schwartz, Thue W. & Frimurer, Thomas Michael, 2 Apr 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7123-7128Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PSX, Protein-Solvent Exchange: software for calculation of deuterium-exchange effects in small-angle neutron scattering measurements from protein coordinates
Pedersen, Martin Cramer, Wang, Y., Tidemand, Frederik Grønbæk, Martel, A., Lindorff-Larsen, Kresten & Arleth, Lise, 2019, In: Journal of Applied Crystallography. 52, 6, p. 1427-1436 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Multi-State Coarse-Grained Simulation Model Captures Conformational Cycling in P-Type ATPases
Wang, Y., Saleh, N., Chu, X. & Lindorff-Larsen, Kresten, 2019, In: Biophysical Journal. 116, 3, suppl. 1, p. 300a 1484-Plat.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Allosteric modulation of the sarcoplasmic reticulum Ca2+ ATPase by thapsigargin via decoupling of functional motions
Saleh, N., Wang, Y., Nissen, P. & Lindorff-Larsen, Kresten, 2019, In: Physical Chemistry Chemical Physics. 21, 39, p. 21991-21995Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Barnaba: software for analysis of nucleic acid structures and trajectories
Bottaro, S., Bussi, G., Pinamonti, G., Reisser, S., Boomsma, Wouter & Lindorff-Larsen, Kresten, 2019, In: RNA. 25, 2, p. 219-231Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bayesian-Maximum-Entropy Reweighting of IDP Ensembles Based on NMR Chemical Shifts
Crehuet, R., Buigues, P. J., Salvatella, X. & Lindorff-Larsen, Kresten, 2019, In: Entropy. 21, 9, 17 p., 898.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical and Mechanistic Models for Disease-Causing Protein Variants
Stein, Amelie, Fowler, D. M., Hartmann-Petersen, Rasmus & Lindorff-Larsen, Kresten, 2019, In: Trends in Biochemical Sciences. 44, 7, p. 575-588Research output: Contribution to journal › Review › Research › peer-review
ID: 35228567
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Protein structure validation and refinement using amide proton chemical shifts derived from quantum mechanics
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Similarity measures for protein ensembles
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Evaluating the effects of cutoffs and treatment of long-range electrostatics in protein folding simulations
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