Adipose tissue expression of IL-18 and HIV-associated lipodystrophy
Research output: Contribution to journal › Journal article › Research › peer-review
IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.
Original language | English |
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Journal | AIDS |
Volume | 18 |
Issue number | 14 |
Pages (from-to) | 1956-1958 |
ISSN | 0269-9370 |
Publication status | Published - 2004 |
ID: 100533