Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans. / U-Din, Mueez; de Mello, Vanessa D.; Tuomainen, Marjo; Raiko, Juho; Niemi, Tarja; Fromme, Tobias; Klåvus, Anton; Gautier, Nadine; Haimilahti, Kimmo; Lehtonen, Marko; Kristiansen, Karsten; Newman, John W.; Pietiläinen, Kirsi H.; Pihlajamäki, Jussi; Amri, Ez Zoubir; Klingenspor, Martin; Nuutila, Pirjo; Pirinen, Eija; Hanhineva, Kati; Virtanen, Kirsi A.

In: Cell Reports, Vol. 42, No. 9, 113131, 26.09.2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

U-Din, M, de Mello, VD, Tuomainen, M, Raiko, J, Niemi, T, Fromme, T, Klåvus, A, Gautier, N, Haimilahti, K, Lehtonen, M, Kristiansen, K, Newman, JW, Pietiläinen, KH, Pihlajamäki, J, Amri, EZ, Klingenspor, M, Nuutila, P, Pirinen, E, Hanhineva, K & Virtanen, KA 2023, 'Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans', Cell Reports, vol. 42, no. 9, 113131. https://doi.org/10.1016/j.celrep.2023.113131

APA

U-Din, M., de Mello, V. D., Tuomainen, M., Raiko, J., Niemi, T., Fromme, T., Klåvus, A., Gautier, N., Haimilahti, K., Lehtonen, M., Kristiansen, K., Newman, J. W., Pietiläinen, K. H., Pihlajamäki, J., Amri, E. Z., Klingenspor, M., Nuutila, P., Pirinen, E., Hanhineva, K., & Virtanen, K. A. (2023). Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans. Cell Reports, 42(9), [113131]. https://doi.org/10.1016/j.celrep.2023.113131

Vancouver

U-Din M, de Mello VD, Tuomainen M, Raiko J, Niemi T, Fromme T et al. Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans. Cell Reports. 2023 Sep 26;42(9). 113131. https://doi.org/10.1016/j.celrep.2023.113131

Author

U-Din, Mueez ; de Mello, Vanessa D. ; Tuomainen, Marjo ; Raiko, Juho ; Niemi, Tarja ; Fromme, Tobias ; Klåvus, Anton ; Gautier, Nadine ; Haimilahti, Kimmo ; Lehtonen, Marko ; Kristiansen, Karsten ; Newman, John W. ; Pietiläinen, Kirsi H. ; Pihlajamäki, Jussi ; Amri, Ez Zoubir ; Klingenspor, Martin ; Nuutila, Pirjo ; Pirinen, Eija ; Hanhineva, Kati ; Virtanen, Kirsi A. / Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans. In: Cell Reports. 2023 ; Vol. 42, No. 9.

Bibtex

@article{d6e9a33333014e5fbe2f0566a490b752,
title = "Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans",
abstract = "Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge of NAD+ metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD+ salvage pathway (nicotinamide and 1-methylnicotinamide) in humans. Additionally, individuals with cold-stimulated BAT activation have decreased levels of metabolites from the de novo NAD+ biosynthesis pathway (tryptophan, kynurenine). Serum nicotinamide correlates positively with cold-stimulated BAT activation, whereas tryptophan and kynurenine correlate negatively. Furthermore, the expression of genes involved in NAD+ biosynthesis in BAT is related to markers of metabolic health. Our data indicate that cold increases serum tryptophan conversion to nicotinamide to be further utilized by BAT. We conclude that NAD+ metabolism is activated upon cold in humans and is probably regulated in a coordinated fashion by several tissues.",
keywords = "BAT, cold exposure, CP: Metabolism, human brown adipose tissue, NAD, nicotinamide, tryptophan",
author = "Mueez U-Din and {de Mello}, {Vanessa D.} and Marjo Tuomainen and Juho Raiko and Tarja Niemi and Tobias Fromme and Anton Kl{\aa}vus and Nadine Gautier and Kimmo Haimilahti and Marko Lehtonen and Karsten Kristiansen and Newman, {John W.} and Pietil{\"a}inen, {Kirsi H.} and Jussi Pihlajam{\"a}ki and Amri, {Ez Zoubir} and Martin Klingenspor and Pirjo Nuutila and Eija Pirinen and Kati Hanhineva and Virtanen, {Kirsi A.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2023",
month = sep,
day = "26",
doi = "10.1016/j.celrep.2023.113131",
language = "English",
volume = "42",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "9",

}

RIS

TY - JOUR

T1 - Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans

AU - U-Din, Mueez

AU - de Mello, Vanessa D.

AU - Tuomainen, Marjo

AU - Raiko, Juho

AU - Niemi, Tarja

AU - Fromme, Tobias

AU - Klåvus, Anton

AU - Gautier, Nadine

AU - Haimilahti, Kimmo

AU - Lehtonen, Marko

AU - Kristiansen, Karsten

AU - Newman, John W.

AU - Pietiläinen, Kirsi H.

AU - Pihlajamäki, Jussi

AU - Amri, Ez Zoubir

AU - Klingenspor, Martin

AU - Nuutila, Pirjo

AU - Pirinen, Eija

AU - Hanhineva, Kati

AU - Virtanen, Kirsi A.

N1 - Publisher Copyright: © 2023 The Author(s)

PY - 2023/9/26

Y1 - 2023/9/26

N2 - Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge of NAD+ metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD+ salvage pathway (nicotinamide and 1-methylnicotinamide) in humans. Additionally, individuals with cold-stimulated BAT activation have decreased levels of metabolites from the de novo NAD+ biosynthesis pathway (tryptophan, kynurenine). Serum nicotinamide correlates positively with cold-stimulated BAT activation, whereas tryptophan and kynurenine correlate negatively. Furthermore, the expression of genes involved in NAD+ biosynthesis in BAT is related to markers of metabolic health. Our data indicate that cold increases serum tryptophan conversion to nicotinamide to be further utilized by BAT. We conclude that NAD+ metabolism is activated upon cold in humans and is probably regulated in a coordinated fashion by several tissues.

AB - Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge of NAD+ metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD+ salvage pathway (nicotinamide and 1-methylnicotinamide) in humans. Additionally, individuals with cold-stimulated BAT activation have decreased levels of metabolites from the de novo NAD+ biosynthesis pathway (tryptophan, kynurenine). Serum nicotinamide correlates positively with cold-stimulated BAT activation, whereas tryptophan and kynurenine correlate negatively. Furthermore, the expression of genes involved in NAD+ biosynthesis in BAT is related to markers of metabolic health. Our data indicate that cold increases serum tryptophan conversion to nicotinamide to be further utilized by BAT. We conclude that NAD+ metabolism is activated upon cold in humans and is probably regulated in a coordinated fashion by several tissues.

KW - BAT

KW - cold exposure

KW - CP: Metabolism

KW - human brown adipose tissue

KW - NAD

KW - nicotinamide

KW - tryptophan

U2 - 10.1016/j.celrep.2023.113131

DO - 10.1016/j.celrep.2023.113131

M3 - Journal article

C2 - 37708023

AN - SCOPUS:85171357961

VL - 42

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 9

M1 - 113131

ER -

ID: 367905499