Isolation of potentially novel species expands the genomic and functional diversity of Lachnospiraceae
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The Lachnospiraceae family holds promise as a source of next-generation probiotics, yet a comprehensive delineation of its diversity is lacking, hampering the identification of suitable strains for future applications. To address this knowledge gap, we conducted an in-depth genomic and functional analysis of 1868 high-quality genomes, combining data from public databases with our new isolates. This data set represented 387 colonization-selective species-level clusters, of which eight genera represented multilineage clusters. Pan-genome analysis, single-nucleotide polymorphism (SNP) identification, and probiotic functional predictions revealed that species taxonomy, habitats, and geography together shape the functional diversity of Lachnospiraceae. Moreover, analyses of associations with atherosclerotic cardiovascular disease (ACVD) and inflammatory bowel disease (IBD) indicated that several strains of potentially novel Lachnospiraceae species possess the capacity to reduce the abundance of opportunistic pathogens, thereby imparting potential health benefits. Our findings shed light on the untapped potential of novel species enabling knowledge-based selection of strains for the development of next-generation probiotics holding promise for improving human health and disease management.
Original language | English |
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Article number | e174 |
Journal | iMeta |
Volume | 3 |
Issue number | 2 |
Number of pages | 18 |
ISSN | 2770-5986 |
DOIs | |
Publication status | Published - 2024 |
Bibliographical note
Funding Information:
The authors also appreciate the colleagues at BGI Research for discussions and the support of Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome. This work was supported by grants from the National Natural Science Foundation of China (No. 32100009), the Natural Science Foundation of Guangdong Province, China (No. 2019B020230001), and Shenzhen Municipal Government of China (No. XMHT20220104017).
Publisher Copyright:
© 2024 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.
- genomic analysis, Lachnospiraceae, next-generation probiotics, probiotic functional predictions
Research areas
ID: 389513159