Osmosensory mechanisms in cellular and systemic volume regulation

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Osmosensory mechanisms in cellular and systemic volume regulation. / Pedersen, Stine Helene Falsig; Kapus, András; Hoffmann, Else K.

In: Journal of the American Society of Nephrology, Vol. 22, No. 9, 2011, p. 1587-97.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pedersen, SHF, Kapus, A & Hoffmann, EK 2011, 'Osmosensory mechanisms in cellular and systemic volume regulation', Journal of the American Society of Nephrology, vol. 22, no. 9, pp. 1587-97. https://doi.org/10.1681/ASN.2010121284

APA

Pedersen, S. H. F., Kapus, A., & Hoffmann, E. K. (2011). Osmosensory mechanisms in cellular and systemic volume regulation. Journal of the American Society of Nephrology, 22(9), 1587-97. https://doi.org/10.1681/ASN.2010121284

Vancouver

Pedersen SHF, Kapus A, Hoffmann EK. Osmosensory mechanisms in cellular and systemic volume regulation. Journal of the American Society of Nephrology. 2011;22(9):1587-97. https://doi.org/10.1681/ASN.2010121284

Author

Pedersen, Stine Helene Falsig ; Kapus, András ; Hoffmann, Else K. / Osmosensory mechanisms in cellular and systemic volume regulation. In: Journal of the American Society of Nephrology. 2011 ; Vol. 22, No. 9. pp. 1587-97.

Bibtex

@article{0e18f3b6ebc44b2f971338faef05ecf5,
title = "Osmosensory mechanisms in cellular and systemic volume regulation",
abstract = "Perturbations of cellular and systemic osmolarity severely challenge the function of all organisms and are consequently regulated very tightly. Here we outline current evidence on how cells sense volume perturbations, with particular focus on mechanisms relevant to the kidneys and to extracellular osmolarity and whole body volume homeostasis. There are a variety of molecular signals that respond to perturbations in cell volume and osmosensors or volume sensors responding to these signals. The early signals of volume perturbation include integrins, the cytoskeleton, receptor tyrosine kinases, and transient receptor potential channels. We also present current evidence on the localization and function of central and peripheral systemic osmosensors and conclude with a brief look at the still limited evidence on pathophysiological conditions associated with deranged sensing of cell volume.",
keywords = "Cell Size, Homeostasis, Kidney, Macrophages, Mechanotransduction, Cellular, Osmolar Concentration",
author = "Pedersen, {Stine Helene Falsig} and Andr{\'a}s Kapus and Hoffmann, {Else K}",
year = "2011",
doi = "10.1681/ASN.2010121284",
language = "English",
volume = "22",
pages = "1587--97",
journal = "Journal of the American Society of Nephrology : JASN",
issn = "1046-6673",
publisher = "The American Society of Nephrology",
number = "9",

}

RIS

TY - JOUR

T1 - Osmosensory mechanisms in cellular and systemic volume regulation

AU - Pedersen, Stine Helene Falsig

AU - Kapus, András

AU - Hoffmann, Else K

PY - 2011

Y1 - 2011

N2 - Perturbations of cellular and systemic osmolarity severely challenge the function of all organisms and are consequently regulated very tightly. Here we outline current evidence on how cells sense volume perturbations, with particular focus on mechanisms relevant to the kidneys and to extracellular osmolarity and whole body volume homeostasis. There are a variety of molecular signals that respond to perturbations in cell volume and osmosensors or volume sensors responding to these signals. The early signals of volume perturbation include integrins, the cytoskeleton, receptor tyrosine kinases, and transient receptor potential channels. We also present current evidence on the localization and function of central and peripheral systemic osmosensors and conclude with a brief look at the still limited evidence on pathophysiological conditions associated with deranged sensing of cell volume.

AB - Perturbations of cellular and systemic osmolarity severely challenge the function of all organisms and are consequently regulated very tightly. Here we outline current evidence on how cells sense volume perturbations, with particular focus on mechanisms relevant to the kidneys and to extracellular osmolarity and whole body volume homeostasis. There are a variety of molecular signals that respond to perturbations in cell volume and osmosensors or volume sensors responding to these signals. The early signals of volume perturbation include integrins, the cytoskeleton, receptor tyrosine kinases, and transient receptor potential channels. We also present current evidence on the localization and function of central and peripheral systemic osmosensors and conclude with a brief look at the still limited evidence on pathophysiological conditions associated with deranged sensing of cell volume.

KW - Cell Size

KW - Homeostasis

KW - Kidney

KW - Macrophages

KW - Mechanotransduction, Cellular

KW - Osmolar Concentration

U2 - 10.1681/ASN.2010121284

DO - 10.1681/ASN.2010121284

M3 - Journal article

C2 - 21852585

VL - 22

SP - 1587

EP - 1597

JO - Journal of the American Society of Nephrology : JASN

JF - Journal of the American Society of Nephrology : JASN

SN - 1046-6673

IS - 9

ER -

ID: 36070017