Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities

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Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities. / Zhang, Xiuying; Zhong, Huanzi; Li, Yufeng; Shi, Zhun; Ren, Huahui; Zhang, Zhe; Zhou, Xianghai; Tang, Shanmei; Han, Xueyao; Lin, Yuxiang; Yang, Fangming; Wang, Dan; Fang, Chao; Fu, Zuodi; Wang, Lianying; Zhu, Shida; Hou, Yong; Xu, Xun; Yang, Huanming; Wang, Jian; Kristiansen, Karsten; Li, Junhua; Ji, Linong.

In: Nature Aging, Vol. 1, No. 1, 2021, p. 87-100.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhang, X, Zhong, H, Li, Y, Shi, Z, Ren, H, Zhang, Z, Zhou, X, Tang, S, Han, X, Lin, Y, Yang, F, Wang, D, Fang, C, Fu, Z, Wang, L, Zhu, S, Hou, Y, Xu, X, Yang, H, Wang, J, Kristiansen, K, Li, J & Ji, L 2021, 'Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities', Nature Aging, vol. 1, no. 1, pp. 87-100. https://doi.org/10.1038/s43587-020-00014-2

APA

Zhang, X., Zhong, H., Li, Y., Shi, Z., Ren, H., Zhang, Z., Zhou, X., Tang, S., Han, X., Lin, Y., Yang, F., Wang, D., Fang, C., Fu, Z., Wang, L., Zhu, S., Hou, Y., Xu, X., Yang, H., ... Ji, L. (2021). Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities. Nature Aging, 1(1), 87-100. https://doi.org/10.1038/s43587-020-00014-2

Vancouver

Zhang X, Zhong H, Li Y, Shi Z, Ren H, Zhang Z et al. Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities. Nature Aging. 2021;1(1):87-100. https://doi.org/10.1038/s43587-020-00014-2

Author

Zhang, Xiuying ; Zhong, Huanzi ; Li, Yufeng ; Shi, Zhun ; Ren, Huahui ; Zhang, Zhe ; Zhou, Xianghai ; Tang, Shanmei ; Han, Xueyao ; Lin, Yuxiang ; Yang, Fangming ; Wang, Dan ; Fang, Chao ; Fu, Zuodi ; Wang, Lianying ; Zhu, Shida ; Hou, Yong ; Xu, Xun ; Yang, Huanming ; Wang, Jian ; Kristiansen, Karsten ; Li, Junhua ; Ji, Linong. / Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities. In: Nature Aging. 2021 ; Vol. 1, No. 1. pp. 87-100.

Bibtex

@article{ebab64f4320443b19cfb89a67835c3d7,

title = "Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities",

abstract = "Lifelong sex- and age-related trajectories of the human gut microbiota remain largely unexplored. Using metagenomics, we derived the gut microbial composition of 2,338 adults (26–76 years) from a Han Chinese population-based cohort where metabolic health, hormone levels and aspects of their lifestyles were also recorded. In this cohort, and in three independent cohorts distributed across China, Israel and the Netherlands, we observed sex differences in the gut microbial composition and a shared age-related decrease in sex-dependent differences in gut microbiota. Compared to men, the gut microbiota of premenopausal women exhibited higher microbial diversity and higher abundances of multiple species known to have beneficial effects on host metabolism. We also found consistent sex-independent, age-related gut microbial characteristics across all populations, with the presence of members of the oral microbiota being the strongest indicator of older chronological age. Our findings highlight the existence of sex- and age-related trajectories in the human gut microbiota that are shared between populations of different ethnicities and emphasize the pivotal links between sex hormones, gut microbiota and host metabolism.",

author = "Xiuying Zhang and Huanzi Zhong and Yufeng Li and Zhun Shi and Huahui Ren and Zhe Zhang and Xianghai Zhou and Shanmei Tang and Xueyao Han and Yuxiang Lin and Fangming Yang and Dan Wang and Chao Fang and Zuodi Fu and Lianying Wang and Shida Zhu and Yong Hou and Xun Xu and Huanming Yang and Jian Wang and Karsten Kristiansen and Junhua Li and Linong Ji",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2021",

doi = "10.1038/s43587-020-00014-2",

language = "English",

volume = "1",

pages = "87--100",

journal = "Nature Aging",

issn = "2662-8465",

publisher = "Nature Research",

number = "1",

}

RIS

TY - JOUR

T1 - Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities

AU - Zhang, Xiuying

AU - Zhong, Huanzi

AU - Li, Yufeng

AU - Shi, Zhun

AU - Ren, Huahui

AU - Zhang, Zhe

AU - Zhou, Xianghai

AU - Tang, Shanmei

AU - Han, Xueyao

AU - Lin, Yuxiang

AU - Yang, Fangming

AU - Wang, Dan

AU - Fang, Chao

AU - Fu, Zuodi

AU - Wang, Lianying

AU - Zhu, Shida

AU - Hou, Yong

AU - Xu, Xun

AU - Yang, Huanming

AU - Wang, Jian

AU - Kristiansen, Karsten

AU - Li, Junhua

AU - Ji, Linong

PY - 2021

Y1 - 2021

N2 - Lifelong sex- and age-related trajectories of the human gut microbiota remain largely unexplored. Using metagenomics, we derived the gut microbial composition of 2,338 adults (26–76 years) from a Han Chinese population-based cohort where metabolic health, hormone levels and aspects of their lifestyles were also recorded. In this cohort, and in three independent cohorts distributed across China, Israel and the Netherlands, we observed sex differences in the gut microbial composition and a shared age-related decrease in sex-dependent differences in gut microbiota. Compared to men, the gut microbiota of premenopausal women exhibited higher microbial diversity and higher abundances of multiple species known to have beneficial effects on host metabolism. We also found consistent sex-independent, age-related gut microbial characteristics across all populations, with the presence of members of the oral microbiota being the strongest indicator of older chronological age. Our findings highlight the existence of sex- and age-related trajectories in the human gut microbiota that are shared between populations of different ethnicities and emphasize the pivotal links between sex hormones, gut microbiota and host metabolism.

AB - Lifelong sex- and age-related trajectories of the human gut microbiota remain largely unexplored. Using metagenomics, we derived the gut microbial composition of 2,338 adults (26–76 years) from a Han Chinese population-based cohort where metabolic health, hormone levels and aspects of their lifestyles were also recorded. In this cohort, and in three independent cohorts distributed across China, Israel and the Netherlands, we observed sex differences in the gut microbial composition and a shared age-related decrease in sex-dependent differences in gut microbiota. Compared to men, the gut microbiota of premenopausal women exhibited higher microbial diversity and higher abundances of multiple species known to have beneficial effects on host metabolism. We also found consistent sex-independent, age-related gut microbial characteristics across all populations, with the presence of members of the oral microbiota being the strongest indicator of older chronological age. Our findings highlight the existence of sex- and age-related trajectories in the human gut microbiota that are shared between populations of different ethnicities and emphasize the pivotal links between sex hormones, gut microbiota and host metabolism.

U2 - 10.1038/s43587-020-00014-2

DO - 10.1038/s43587-020-00014-2

M3 - Journal article

AN - SCOPUS:85101919244

VL - 1

SP - 87

EP - 100

JO - Nature Aging

JF - Nature Aging

SN - 2662-8465

IS - 1

ER -

ID: 317501141

Department of Biology