Studying mutation rate evolution in primates - a need for systematic comparison of computational pipelines
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The lack of consensus methods to estimate germline mutation rates from pedigrees has led to substantial differences in computational pipelines in the published literature. Here, we answer Susanne Pfeifer's opinion piece discussing the pipeline choices of our recent article estimating the germline mutation rate of rhesus macaques (Macaca mulatta). We acknowledge the differences between the method that we applied and the one preferred by Pfeifer. Yet, we advocate for full transparency and justification of choices as long as rigorous comparison of pipelines remains absent because it is the only way to conclude on best practices for the field.
Original language | English |
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Article number | giab072 |
Journal | GigaScience |
Volume | 10 |
Issue number | 10 |
Number of pages | 4 |
ISSN | 2047-217X |
DOIs | |
Publication status | Published - 2021 |
Bibliographical note
Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press GigaScience.
- computational pipeline, germline mutation rate, NGS sequencing
Research areas
ID: 286995016