Translocation of non-lytic antimicrobial peptides and bacteria penetrating peptides across the inner membrane of the bacterial envelope

Research output: Contribution to journal › Review › Research › peer-review

Standard

Translocation of non-lytic antimicrobial peptides and bacteria penetrating peptides across the inner membrane of the bacterial envelope. / Frimodt-Møller, Jakob; Campion, Christopher; Nielsen, Peter E.; Løbner-Olesen, Anders.

In: Current Genetics, Vol. 68, No. 1, 2022, p. 83-90.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Frimodt-Møller, J, Campion, C, Nielsen, PE & Løbner-Olesen, A 2022, 'Translocation of non-lytic antimicrobial peptides and bacteria penetrating peptides across the inner membrane of the bacterial envelope', Current Genetics, vol. 68, no. 1, pp. 83-90. https://doi.org/10.1007/s00294-021-01217-9

APA

Frimodt-Møller, J., Campion, C., Nielsen, P. E., & Løbner-Olesen, A. (2022). Translocation of non-lytic antimicrobial peptides and bacteria penetrating peptides across the inner membrane of the bacterial envelope. Current Genetics, 68(1), 83-90. https://doi.org/10.1007/s00294-021-01217-9

Vancouver

Frimodt-Møller J, Campion C, Nielsen PE, Løbner-Olesen A. Translocation of non-lytic antimicrobial peptides and bacteria penetrating peptides across the inner membrane of the bacterial envelope. Current Genetics. 2022;68(1):83-90. https://doi.org/10.1007/s00294-021-01217-9

Author

Frimodt-Møller, Jakob ; Campion, Christopher ; Nielsen, Peter E. ; Løbner-Olesen, Anders. / Translocation of non-lytic antimicrobial peptides and bacteria penetrating peptides across the inner membrane of the bacterial envelope. In: Current Genetics. 2022 ; Vol. 68, No. 1. pp. 83-90.

Bibtex

@article{adb3931ee00b491a906113c5c73cbb84,
title = "Translocation of non-lytic antimicrobial peptides and bacteria penetrating peptides across the inner membrane of the bacterial envelope",
abstract = "The increase in multidrug-resistant pathogenic bacteria has become a problem worldwide. Currently there is a strong focus on the development of novel antimicrobials, including antimicrobial peptides (AMP) and antimicrobial antisense agents. While the majority of AMP have membrane activity and kill bacteria through membrane disruption, non-lytic AMP are non-membrane active, internalize and have intracellular targets. Antimicrobial antisense agents such as peptide nucleic acids (PNA) and phosphorodiamidate morpholino oligomers (PMO), show great promise as novel antibacterial agents, killing bacteria by inhibiting translation of essential target gene transcripts. However, naked PNA and PMO are unable to translocate across the cell envelope of bacteria, to reach their target in the cytosol, and are conjugated to bacteria penetrating peptides (BPP) for cytosolic delivery. Here, we discuss how non-lytic AMP and BPP-PMO/PNA conjugates translocate across the cytoplasmic membrane via receptor-mediated transport, such as the cytoplasmic membrane transporters SbmA, MdtM/YjiL, and/or YgdD, or via a less well described autonomous process.",
keywords = "Antimicrobial antisense agents, Bacteria penetrating peptides, Bacterial membranes, Non-lytic antimicrobial peptides",
author = "Jakob Frimodt-M{\o}ller and Christopher Campion and Nielsen, {Peter E.} and Anders L{\o}bner-Olesen",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2022",
doi = "10.1007/s00294-021-01217-9",
language = "English",
volume = "68",
pages = "83--90",
journal = "Current Genetics",
issn = "0172-8083",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Translocation of non-lytic antimicrobial peptides and bacteria penetrating peptides across the inner membrane of the bacterial envelope

AU - Frimodt-Møller, Jakob

AU - Campion, Christopher

AU - Nielsen, Peter E.

AU - Løbner-Olesen, Anders

N1 - Publisher Copyright: © 2021, The Author(s).

PY - 2022

Y1 - 2022

N2 - The increase in multidrug-resistant pathogenic bacteria has become a problem worldwide. Currently there is a strong focus on the development of novel antimicrobials, including antimicrobial peptides (AMP) and antimicrobial antisense agents. While the majority of AMP have membrane activity and kill bacteria through membrane disruption, non-lytic AMP are non-membrane active, internalize and have intracellular targets. Antimicrobial antisense agents such as peptide nucleic acids (PNA) and phosphorodiamidate morpholino oligomers (PMO), show great promise as novel antibacterial agents, killing bacteria by inhibiting translation of essential target gene transcripts. However, naked PNA and PMO are unable to translocate across the cell envelope of bacteria, to reach their target in the cytosol, and are conjugated to bacteria penetrating peptides (BPP) for cytosolic delivery. Here, we discuss how non-lytic AMP and BPP-PMO/PNA conjugates translocate across the cytoplasmic membrane via receptor-mediated transport, such as the cytoplasmic membrane transporters SbmA, MdtM/YjiL, and/or YgdD, or via a less well described autonomous process.

AB - The increase in multidrug-resistant pathogenic bacteria has become a problem worldwide. Currently there is a strong focus on the development of novel antimicrobials, including antimicrobial peptides (AMP) and antimicrobial antisense agents. While the majority of AMP have membrane activity and kill bacteria through membrane disruption, non-lytic AMP are non-membrane active, internalize and have intracellular targets. Antimicrobial antisense agents such as peptide nucleic acids (PNA) and phosphorodiamidate morpholino oligomers (PMO), show great promise as novel antibacterial agents, killing bacteria by inhibiting translation of essential target gene transcripts. However, naked PNA and PMO are unable to translocate across the cell envelope of bacteria, to reach their target in the cytosol, and are conjugated to bacteria penetrating peptides (BPP) for cytosolic delivery. Here, we discuss how non-lytic AMP and BPP-PMO/PNA conjugates translocate across the cytoplasmic membrane via receptor-mediated transport, such as the cytoplasmic membrane transporters SbmA, MdtM/YjiL, and/or YgdD, or via a less well described autonomous process.

KW - Antimicrobial antisense agents

KW - Bacteria penetrating peptides

KW - Bacterial membranes

KW - Non-lytic antimicrobial peptides

U2 - 10.1007/s00294-021-01217-9

DO - 10.1007/s00294-021-01217-9

M3 - Review

C2 - 34750687

AN - SCOPUS:85118635381

VL - 68

SP - 83

EP - 90

JO - Current Genetics

JF - Current Genetics

SN - 0172-8083

IS - 1

ER -

ID: 284701102