Volume regulation in epithelia

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Volume regulation in epithelia. / Larsen, Erik Hviid; Hoffmann, Else Kay.

Ion channels and transporters of epithelia in health and disease. ed. / Kirk L. Hamiltion; Daniel C. Devor. Vol. Part 1 Springer, 2016. p. 131-185 (Physiology in Health and Disease).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Larsen, EH & Hoffmann, EK 2016, Volume regulation in epithelia. in KL Hamiltion & DC Devor (eds), Ion channels and transporters of epithelia in health and disease. vol. Part 1, Springer, Physiology in Health and Disease, pp. 131-185. https://doi.org/10.1007/978-1-4939-3366-2_4

APA

Larsen, E. H., & Hoffmann, E. K. (2016). Volume regulation in epithelia. In K. L. Hamiltion, & D. C. Devor (Eds.), Ion channels and transporters of epithelia in health and disease (Vol. Part 1, pp. 131-185). Springer. Physiology in Health and Disease https://doi.org/10.1007/978-1-4939-3366-2_4

Vancouver

Larsen EH, Hoffmann EK. Volume regulation in epithelia. In Hamiltion KL, Devor DC, editors, Ion channels and transporters of epithelia in health and disease. Vol. Part 1. Springer. 2016. p. 131-185. (Physiology in Health and Disease). https://doi.org/10.1007/978-1-4939-3366-2_4

Author

Larsen, Erik Hviid ; Hoffmann, Else Kay. / Volume regulation in epithelia. Ion channels and transporters of epithelia in health and disease. editor / Kirk L. Hamiltion ; Daniel C. Devor. Vol. Part 1 Springer, 2016. pp. 131-185 (Physiology in Health and Disease).

Bibtex

@inbook{f83ada3010204035ab0cb9aa5378ed73,
title = "Volume regulation in epithelia",
abstract = "We review studies on regulatory volume decrease (RVD) and regulatoryvolume increase (RVI) of major ion and water transporting vertebrate epithelia. The rate of RVD and RVI is faster in cells of high osmotic permeability like amphibian gallbladder and mammalian proximal tubule as compared to amphibian skin and mammalian cortical collecting tubule of low and intermediate osmotic permeability. Crosstalk between entrance and exit mechanisms interferes with volume regulation both at aniso-osmotic and iso-osmotic volume perturbations. It has been proposed that cell volume regulation is an intrinsic function of iso-osmotic fluid transport that depends on Na+ recirculation. The causative relationship is discussed for a fluid-absorbing and a fluid-secreting epithelium of which the Na+ recirculation mechanisms have been identified.A large number of transporters and ion channels involved in cell volume regulation are cloned. The volume-regulated anion channel (VRAC) exhibiting specific electrophysiological characteristics seems exclusive to serve cell volume regulation. This is contrary to K+ channels as well as cotransporters and exchange mechanisms that may serve both transepithelial transport and cell volume regulation. In the same cell, these functions may be maintained by different ion pathways that are separately regulated. RVD is often preceded by increase in cytosolic free Ca2+, probably via influx through TRP channels, but Ca2+ release from intracellular stores has also been observed. Cellvolume regulation is associated with specific ATP release mechanisms and involves tyrosine kinases, mitogen-activated protein kinases, WNKs and Ste20-related kinases that are modulated by osmotic stress and cell volume perturbations.",
author = "Larsen, {Erik Hviid} and Hoffmann, {Else Kay}",
year = "2016",
doi = "10.1007/978-1-4939-3366-2_4",
language = "English",
isbn = "978-1-4939-3364-8",
volume = "Part 1",
series = "Physiology in Health and Disease",
pages = "131--185",
editor = "Hamiltion, {Kirk L.} and Devor, {Daniel C.}",
booktitle = "Ion channels and transporters of epithelia in health and disease",
publisher = "Springer",
address = "Switzerland",

}

RIS

TY - CHAP

T1 - Volume regulation in epithelia

AU - Larsen, Erik Hviid

AU - Hoffmann, Else Kay

PY - 2016

Y1 - 2016

N2 - We review studies on regulatory volume decrease (RVD) and regulatoryvolume increase (RVI) of major ion and water transporting vertebrate epithelia. The rate of RVD and RVI is faster in cells of high osmotic permeability like amphibian gallbladder and mammalian proximal tubule as compared to amphibian skin and mammalian cortical collecting tubule of low and intermediate osmotic permeability. Crosstalk between entrance and exit mechanisms interferes with volume regulation both at aniso-osmotic and iso-osmotic volume perturbations. It has been proposed that cell volume regulation is an intrinsic function of iso-osmotic fluid transport that depends on Na+ recirculation. The causative relationship is discussed for a fluid-absorbing and a fluid-secreting epithelium of which the Na+ recirculation mechanisms have been identified.A large number of transporters and ion channels involved in cell volume regulation are cloned. The volume-regulated anion channel (VRAC) exhibiting specific electrophysiological characteristics seems exclusive to serve cell volume regulation. This is contrary to K+ channels as well as cotransporters and exchange mechanisms that may serve both transepithelial transport and cell volume regulation. In the same cell, these functions may be maintained by different ion pathways that are separately regulated. RVD is often preceded by increase in cytosolic free Ca2+, probably via influx through TRP channels, but Ca2+ release from intracellular stores has also been observed. Cellvolume regulation is associated with specific ATP release mechanisms and involves tyrosine kinases, mitogen-activated protein kinases, WNKs and Ste20-related kinases that are modulated by osmotic stress and cell volume perturbations.

AB - We review studies on regulatory volume decrease (RVD) and regulatoryvolume increase (RVI) of major ion and water transporting vertebrate epithelia. The rate of RVD and RVI is faster in cells of high osmotic permeability like amphibian gallbladder and mammalian proximal tubule as compared to amphibian skin and mammalian cortical collecting tubule of low and intermediate osmotic permeability. Crosstalk between entrance and exit mechanisms interferes with volume regulation both at aniso-osmotic and iso-osmotic volume perturbations. It has been proposed that cell volume regulation is an intrinsic function of iso-osmotic fluid transport that depends on Na+ recirculation. The causative relationship is discussed for a fluid-absorbing and a fluid-secreting epithelium of which the Na+ recirculation mechanisms have been identified.A large number of transporters and ion channels involved in cell volume regulation are cloned. The volume-regulated anion channel (VRAC) exhibiting specific electrophysiological characteristics seems exclusive to serve cell volume regulation. This is contrary to K+ channels as well as cotransporters and exchange mechanisms that may serve both transepithelial transport and cell volume regulation. In the same cell, these functions may be maintained by different ion pathways that are separately regulated. RVD is often preceded by increase in cytosolic free Ca2+, probably via influx through TRP channels, but Ca2+ release from intracellular stores has also been observed. Cellvolume regulation is associated with specific ATP release mechanisms and involves tyrosine kinases, mitogen-activated protein kinases, WNKs and Ste20-related kinases that are modulated by osmotic stress and cell volume perturbations.

U2 - 10.1007/978-1-4939-3366-2_4

DO - 10.1007/978-1-4939-3366-2_4

M3 - Book chapter

SN - 978-1-4939-3364-8

VL - Part 1

T3 - Physiology in Health and Disease

SP - 131

EP - 185

BT - Ion channels and transporters of epithelia in health and disease

A2 - Hamiltion, Kirk L.

A2 - Devor, Daniel C.

PB - Springer

ER -

ID: 135484485