Jakob R. Winther
Professor
Biomolecular Sciences
Ole Maaløes Vej 5
2200 København N.
- 1999
Functional properties of the two redox-active sites in yeast protein disulphide isomerase in vitro and in vivo
Westphal, V., Darby, N. J. & Winther, Jakob R., 1999, In: Journal of Molecular Biology. 286, 4, p. 1229-1239 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Ligand recognition and domain structure of Vps10p, a vacuolar protein sorting receptor in Saccharomyces cerevisiae
Jørgensen, M. U., Emr, S. D. & Winther, Jakob R., 1999, In: European Journal of Biochemistry. 260, 2, p. 461-469 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Protein oxidation: prime suspect found 'not guilty'
Bader, M., Winther, Jakob R. & Bardwell, J. C. A., 1999, In: Nature Cell Biology. 1, 3, p. E57-E58Research output: Contribution to journal › Comment/debate › Communication
- 2000
- Published
Purification, co-crystallization and preliminary X-ray analysis of the natural aspartic proteinase inhibitor I(A)3 complexed with saccharopepsin from Saccharomyces cerevisiae
Badasso, M. O., Read, J. A., Dhanaraj, V., Cooper, J. B., Wood, S. P., Blundell, T. L., Dreyer, T. & Winther, Jakob R., 2000, In: Acta Crystallographica Section D: Biological Crystallography.Research output: Contribution to journal › Journal article › Research › peer-review
The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix
Li, M., Phylip, L. H., Lees, W. E., Winther, Jakob R., Dunn, B. M., Wlodawer, A., Kay, J. & Gustchina, A., 2000, In: Nature Structural & Molecular Biology. 7, 2, p. 113-117 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
Barley lipid transfer protein, LTP1, contains a new type of lipid-like post-translational modification
Lindorff-Larsen, K., Lerche, M. H., Poulsen, F. M., Roepstorff, P. & Winther, Jakob R., 2001, In: Journal of Biological Chemistry. 276, 36, p. 33547-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Functional differences in yeast protein disulfide isomerases
Nørgaard, P., Westphal, V., Tachibana, C., Alsøe, L., Holst, B. & Winther, Jakob R., 2001, In: Journal of Cell Biology. 152, 3, p. 553-562 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mutation of yeast Eug1p CXXS active sites to CXXC results in a dramatic increase in protein disulphide isomerase activity
Nørgaard, P. & Winther, Jakob R., 2001, In: Biochemical Journal. 358, 1, p. 269-274 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Production of a heterologous proteinase A by Saccharomyces kluyveri
Møller, K., Tidemand, L. D., Winther, Jakob R., Olsson, L., Piskur, J. & Nielsen, J., 2001, In: Applied Microbiology and Biotechnology. 57, 1-2, p. 216-219 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein
Østergaard, H., Henriksen, A., Hansen, F. G. & Winther, Jakob R., 2001, In: EMBO Journal. 20, 21, p. 5853-5862 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Surprisingly high stability of barley lipid transfer protein, LTP1, towards denaturant, heat and proteases
Lindorff-Larsen, Kresten & Winther, Jakob R., 2001, In: FEBS Letters. 488, 3, p. 145-148 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
The Potency and Specificity of the Interaction between the IA3 Inhibitor and Its Target Aspartic Proteinase from Saccharomyces cerevisiae
Phylip, L. H., Lees, W. E., Brownsey, B. G., Bur, D., Dunn, B. M., Winther, Jakob R., Gustchina, A., Li, M., Copeland, T., Wlodawer, A. & Kay, J., 2001, In: Journal of Biological Chemistry. 276, 3, p. 2023-2030 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
Gene regulation in response to protein disulphide isomerase deficiency
Nørgaard, P., Tachibana, C., Bruun, A. W. & Winther, Jakob R., 2003, In: Yeast. 20, 7, p. 645-652 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
Fluorometric polyethyleneglycol-peptide hybrid substrates for quantitative assay of protein disulfide isomerase
Christiansen, C., Hilaire, P. M. S. & Winther, Jakob R., 2004, In: Analytical Biochemistry. 333, 1, p. 148-155 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Monitoring disulfide bond formation in the eukaryotic cytosol
Østergaard, H., Tachibana, C. & Winther, Jakob R., 2004, In: Journal of Cell Biology. 166, 3, p. 337-345 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Saccharopepsin
Winther, Jakob R., Phylip, L. H. & Kay, J., 2004, Aspartic and Metallo Peptidases. Barrett, A. J., Rawlings, N. D. & Woessner, J. F. (eds.). 2. ed. Elsevier, p. 87-90 4 p. (Handbook of Proteolytic Enzymes, Vol. 1).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
The Contributions of Protein Disulfide Isomerase and Its Homologues to Oxidative Protein Folding in the Yeast Endoplasmic Reticulum
Xiao, R., Wilkinson, B., Solovyov, A., Winther, Jakob R., Holmgren, A., Lundström-Ljung, J. & Gilbert, H. F., 2004, In: Journal of Biological Chemistry. 279, 48, p. 49780-49786 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Increasing the reactivity of an artificial dithiol-bisulfide pair through modification of the electrostatic milieu
Hansen, R. E., Østergaard, H. & Winther, Jakob R., 2005, In: Biochemistry.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increasing the reactivity of an artificial dithiol-disulfide pair through modification of the electrostatic milieu
Hansen, R. E., Østergaard, H. & Winther, Jakob R., 2005, In: Biochemistry. 44, 15, p. 5899-906 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Crystallization of mutant forms of glutaredoxin Grx1p from yeast
Håkansson, K. O., Østergaard, H. & Winther, Jakob R., 2006, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 62, 9, p. 920-922Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence that translation reinitiation leads to a partially functional Menkes protein containing two copper-binding sites
Paulsen, M., Lund, C., Akram, Z., Winther, Jakob R., Horn, N. & Møller, L. B., 2006, In: American Journal of Human Genetics. 79, 2, p. 214-29 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Measuring intracellular redox conditions using GFP-based sensors
Björnberg, O., Ostergaard, H. & Winther, Jakob R., 2006, In: Antioxidants & Redox Signaling. 8, 3-4, p. 354-61 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanistic insight provided by glutaredoxin within a fusion to redox-sensitive yellow fluorescent protein
Björnberg, O., Østergaard, H. & Winther, Jakob R., 2006, In: Biochemistry. 45, 7, p. 2362-71 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Cytoplasmic glutathione redox status determines survival upon exposure to the thiol-oxidant 4,4'-dipyridyl disulfide.
López-Mirabal, H. R., Thorsen, M., Kielland-Brandt, M. C., Toledano, M. B. & Winther, Jakob R., 2007, In: FEMS Yeast Research. 7, 3, p. 391-403 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erv2p: characterization of the redox behavior of a yeast sulfhydryl oxidase.
Wang, W., Winther, Jakob R. & Thorpe, C., 2007, In: Biochemistry. 46, 11, p. 3246-54 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5143
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In Silico prediction of mutant HIV-1 proteases cleaving a target sequence
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A soluble, folded protein without charged amino acid residues
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Computational redesign of thioredoxin is hypersensitive towards minor conformational changes in the backbone template
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