Jakob R. Winther
Professor
Biomolecular Sciences
Ole Maaløes Vej 5
2200 København N.
- 2007
- Published
Genetic interaction between the ero1-1 and leu2 mutations in Saccharomyces cerevisiae.
López-Mirabal, H. R., Winther, Jakob R. & Kielland-Brandt, M. C., 2007, In: Bioscience, Biotechnology, and Biochemistry. 71, 12, p. 2934-42 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quantification of protein thiols and dithiols in the picomolar range using sodium borohydride and 4,4'-dithiodipyridine.
Hansen, R. E., Østergaard, H., Nørgaard, P. & Winther, Jakob R., 2007, In: Analytical Biochemistry. 363, 1, p. 77-82 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Redox characteristics of the eukaryotic cytosol.
López-Mirabal, H. R. & Winther, Jakob R., 2007, In: BBA General Subjects.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of glutaredoxin Grx1p C30S mutant from yeast.
Håkansson, K. O. & Winther, Jakob R., 2007, In: Acta Crystallographica. Section D: Biological Crystallography. 63, Pt 3, p. 288-94 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The thiol oxidant dipyridyl disulfide can supply the PDI-Ero1p pathway with additional oxidative equivalents.
López-Mirabal, H. R. & Winther, Jakob R., 2007, In: Antonie van Leeuwenhoek. International Journal of General and Molecular Microbiology. 92, 4, p. 463-72 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
High-resolution imaging of redox signaling in live cells through an oxidation-sensitive yellow fluorescent protein
Maulucci, G., Labate, V., Mele, M., Panieri, E., Arcovito, G., Galeotti, T., Østergaard, H., Winther, Jakob R., De Spirito, M. & Pani, G., 2008, In: Science Signaling. 1, 43, p. pl3 1-15 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutations in the RAM network confer resistance to the thiol oxidant 4,4'-dipyridyl disulfide
López-Mirabal, H. R., Winther, Jakob R., Thorsen, M. & Kielland-Brandt, M. C., 2008, In: Molecular Genetics and Genomics. 279, 6, p. 629-42 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxidant resistance in a yeast mutant deficient in the Sit4 phosphatase
López-Mirabal, H. R., Winther, Jakob R. & Kielland-Brandt, M. C., 2008, In: Current Genetics. 53, 5, p. 275-86 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
An introduction to methods for analyzing thiols and disulfides: Reactions, reagents, and practical considerations
Hansen, R. E. & Winther, Jakob R., 2009, In: Analytical Biochemistry. 394, 2, p. 147-58 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kinetic and Thermodynamic Aspects of Cellular Thiol-Disulfide Redox Regulation
Jensen, K. S., Hansen, R. E. & Winther, Jakob R., 2009, In: Antioxidants & Redox Signaling. 11, 5, p. 1047-1058Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quantifying the global cellular thiol-disulfide status
Hansen, R. E., Roth, D. & Winther, Jakob R., 2009, In: Proceedings of the National Academy of Science of the United States of America. 106, 2, p. 422-427 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Kinetic and thermodynamic properties of two barley thioredoxin h isozymes, HvTrxh1 and HvTrxh2
Maeda, K., Hägglund, Per Mårten, Björnberg, O., Winther, Jakob R. & Svensson, B., 2010, In: FEBS Letters. 584, 15, p. 3376-3380 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Thiol-Disulfide Exchange between Glutaredoxin and Glutathione
Iversen, R., Andersen, P. A., Jensen, K. S., Winther, Jakob R. & Sigurskjold, B. W., 2010, In: Biochemistry. 49, 4, p. 810-820 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Millisecond dynamics in glutaredoxin during catalytic turnover is dependent on substrate binding and absent in the resting states
Jensen, K. S., Winther, Jakob R. & Teilum, Kaare, 2011, In: Journal of the American Chemical Society. 133, 9, p. 3034-42 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trisulfides in Proteins
Nielsen, R. W., Tachibana, C., Hansen, N. E. & Winther, Jakob R., 2011, In: Antioxidants & Redox Signaling. 15, 1, p. 67-75 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
A fluorescent probe which allows highly specific thiol labeling at low pH
Nielsen, J. W., Jensen, K. S., Hansen, R. R. E., Gotfredsen, C. H. & Winther, Jakob R., 2012, In: Analytical Biochemistry. 421, 1, p. 115-120 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metal-ion dependent catalytic properties of Sulfolobus solfataricus class II α-mannosidase
Nielsen, J. W., Poulsen, N. R., Johnsson, A. M. S., Winther, Jakob R., Stipp, S. L. S. & Willemoës, Martin, 2012, In: Biochemistry. 51, 40, p. 8039-8046 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polysaccharide effects on calcite growth: the influence of composition and branching
Nielsen, J. W., Sand, Karina Krarup, Pedersen, C. S., Lakshtanov, L. Z., Winther, Jakob R., Willemoës, Martin & Stipp, S. L. S., 2012, In: Crystal Growth & Design. 12, 10, p. 4906-4910 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The human selenoprotein VCP-interacting membrane protein (VIMP) is non-globular and harbors a reductase function in an intrinsically disordered region
Christensen, L. C., Jensen, N. W., Lages Lino Vala, A., Kamarauskaite, J., Johansson, L. C., Winther, Jakob R., Hofmann, K., Teilum, Kaare & Ellgaard, Lars, 2012, In: Journal of Biological Chemistry. 287, 31, p. 26388-26399 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Intracellular glutathione pools are heterogeneously concentrated
Montero, D., Tachibana, C., Winther, Jakob R. & Appenzeller-Herzog, C., 2013, In: Redox Biology. 1, 1, p. 508-513 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quantifying changes in the cellular thiol-disulfide status during differentiation of B cells into antibody-secreting plasma cells
Hansen, R. R. E., Otsu, M., Braakman, I. & Winther, Jakob R., 2013, In: International Journal of Cell Biology. 2013, 10 p., 898563.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Redox control: a black hole for oxidized glutathione
Winther, Jakob R. & Jakob, U., 2013, In: Nature Chemical Biology. 9, 2, p. 69-70 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Saccharopepsin
Winther, Jakob R., Webb, H. & Kay, J., 2013, Handbook of Proteolytic Enzymes. Rawlings, N. D. & Salvesen, G. (eds.). Third Edition ed. Academic Press, Vol. 1. p. 128-133 6 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2014
- Published
In Silico prediction of mutant HIV-1 proteases cleaving a target sequence
Jensen, Jan Halborg, Willemoës, Martin, Winther, Jakob R. & De Vico, L., 2014, In: P L o S One. 9, 5, 11 p., 5.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Catalytic site interactions in yeast OMP synthase
Hansen, M. R., Barr, E. W., Jensen, K. F., Willemoës, Martin, Grubmeyer, C. & Winther, Jakob R., 2014, In: Archives of Biochemistry and Biophysics. 542, p. 28-38 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Non-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes
Christensen, Caspar Elo, Karlsson, M., Winther, Jakob R., Jensen, P. R. & Lerche, M. H., 2014, In: The Journal of Biological Chemistry. 289, 4, p. 2344-2352 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quantification of thiols and disulfides
Winther, Jakob R. & Thorpe, C., 2014, In: BBA General Subjects. 1840, 2, p. 838-846 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Rapid TaqMan-based quantification of chlorophyll d-containing cyanobacteria in the genus Acaryochloris
Behrendt, L., Nielsen, J. L., Sørensen, Søren Johannes, Larkum, A. W. D., Winther, Jakob R. & Kühl, Michael, 2014, In: Applied and Environmental Microbiology. 80, 10, p. 3244-3249 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The pKa value and accessibility of cysteine residues are key determinants for protein substrate discrimination by glutaredoxin
Jensen, K. S., Pedersen, J. T., Winther, Jakob R. & Teilum, Kaare, 2014, In: Biochemistry. 53, 15, p. 2533-2540 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Mutational analysis of divalent metal ion binding in the active site of class II α-mannosidase from Sulfolobus solfataricus
Hansen, D., Webb, H., Nielsen, J. W., Harris, P., Winther, Jakob R. & Willemoës, Martin, 2015, In: Biochemistry. 54, 11, p. 2032-2039 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Visualization of nanofibrillar cellulose in biological tissues using a biotinylated carbohydrate binding module of β-1,4-Glycanase
Knudsen, K. B., Kofoed, Christian, Espersen, R., Højgaard, C., Winther, Jakob R., Willemoës, Martin, Wedin, I., Nuopponen, M., Vilske, S., Aimonen, K., Weydahl, I. E. K., Alenius, H., Norppa, H., Wolff, H., Wallin, E. H. R. & Vogel, U., 2015, In: Chemical Research in Toxicology. 28, 8, p. 1627-1635 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
A soluble, folded protein without charged amino acid residues
Højgaard, C., Kofoed, Christian, Espersen, R., Johansson, Kristoffer Enøe, Villa, M., Willemoës, Martin, Lindorff-Larsen, Kresten, Teilum, Kaare & Winther, Jakob R., 2016, In: Biochemistry. 55, 28, p. 3949–3956 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computational redesign of thioredoxin is hypersensitive towards minor conformational changes in the backbone template
Johansson, Kristoffer Enøe, Johansen, Nicolai Tidemand, Christensen, S., Horowitz, S., Bardwell, J. C. A., Olsen, Johan Gotthardt, Willemoës, Martin, Lindorff-Larsen, Kresten, Ferkinghoff-Borg, J., Hamelryck, Thomas Wim & Winther, Jakob R., 2016, In: Journal of Molecular Biology. 428, 21, p. 4361-4377 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Exploring the antigenic response to multiplexed immunizations in a chicken model of antibody production
Kousted, T. M., Kalliokoski, Otto, Christensen, S. K., Winther, Jakob R. & Hau, Jann, Mar 2017, In: Heliyon. 3, 3, 19 p., e00267.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Positive staining for cellulose in oral pulse granuloma
Virkkunen, S., Wolff, H., Haglund, C., Højgaard, C., Winther, Jakob R., Willemoës, Martin, Vogel, U. & Hagström, J., Apr 2017, In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 123, 4, p. 464-467 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Endoplasmic reticulum transport of glutathione by Sec61 is regulated by Ero1 and Bip
Ponsero, A. J., Igbaria, A., Darch, M. A., Miled, S., Outten, C. E., Winther, Jakob R., Palais, G., D'Autréaux, B., Delaunay-Moisan, A. & Toledano, M. B., 21 Sep 2017, In: Molecular Cell. 67, 6, p. 962-973.e5 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evolution i overhalingsbanen
Abildgaard, A. B., Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Winther, Jakob R., 15 Dec 2017, In: Weekendavisen. 2017, 50, p. Ideer: 13 1 p.Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
- 2018
- Published
A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel
Santner, P., Martins, J. M. D. S., Laursen, J. S., Behrendt, L., Riber, Leise, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5949-5956Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Can a Charged Surfactant Unfold an Uncharged Protein?
Højgaard, C., Sørensen, H. V., Pedersen, J. S., Winther, Jakob R. & Otzen, D. E., 2018, In: Biophysical Journal. 115, 11, p. 2081-2086 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Editorial overview: A perspective on protein evolution
Hoecker, B. & Winther, Jakob R., 2018, In: Current Opinion in Structural Biology. 48, p. viii-ix 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month
Ilves, M., Vilske, S., Aimonen, K., Lindberg, H. K., Pesonen, S., Wedin, I., Nuopponen, M., Vanhala, E., Højgaard, C., Winther, Jakob R., Willemoës, Martin, Vogel, U., Wolff, H., Norppa, H., Savolainen, K. & Alenius, H., 2018, In: Nanotoxicology. 12, 7, p. 729-746 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein evolution: Hacking an enzyme
Johansson, Kristoffer Enøe & Winther, Jakob R., 2018, In: Nature Chemical Biology. 14, 3, p. 202-204 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Random mutagenesis analysis of the Influenza A M2 proton channel reveals novel resistance mutants
Santner, P., Martins, J. M. D. S., Kampmeyer, Caroline, Hartmann-Petersen, Rasmus, Laursen, J. S., Stein, Amelie, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5957-5968Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comprehensive mapping of GFP structure-function relationship using high-density peptide arrays
Antonescu, O., Johansson, Kristoffer Enøe & Winther, Jakob R., 10 Jul 2018.Research output: Contribution to conference › Poster › Research › peer-review
- 2019
- Published
Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses
Hadrup, N., Knudsen, K. B., Berthing, T., Wolff, H., Bengtson, S., Kofoed, Christian, Espersen, R., Højgaard, C., Winther, Jakob R., Willemoës, Martin, Wedin, I., Nuopponen, M., Alenius, H., Norppa, H., Wallin, H. & Vogel, U., 2019, In: Environmental Toxicology and Pharmacology. 66, p. 116-125 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Steady state kinetic analysis of O-linked GalNAc glycan release catalyzed by endo-α-N-acetylgalactosaminidase
Hansen, D. K., Winther, Jakob R. & Willemoës, Martin, 2019, In: Carbohydrate Research. 480, p. 54-60Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Shining light on split fluorescent protein fitness landscapes using peptide array-based deep substitutional scanning
ANTONESCU, O., Johansson, Kristoffer Enøe & Winther, Jakob R., 30 Jun 2019.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Improving folding properties of computationally designed proteins
Bjerre, B., Nissen, J., Madsen, M., Kamarauskaite, J., Norrild, R. K., Holm, Peter Christoffer, Nordentoft, M. K., O'Shea, Charlotte, Willemoës, Martin, Johansson, Kristoffer Enøe & Winther, Jakob R., 13 Dec 2019, In: Protein Engineering Design and Selection (Print). 32, 3, p. 145-151 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water
Kampmeyer, Caroline, Johansen, Jens Vilstrup, Holmberg, Christian, Karlson, M., Gersing, S. K., Nunes Bordallo, Heloisa, Kragelund, Birthe Brandt, Lerche, M. H., Jourdain, I., Winther, Jakob R. & Hartmann-Petersen, Rasmus, 2020, In: A C S Synthetic Biology. 9, 4, p. 733-748 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry
Abramsson, M. L., Sahin, C., Hopper, J. T. S., Branca, R. M. M., Danielsson, J., Xu, M., Chandler, S. A., Österlund, N., Ilag, L. L., Leppert, A., Costeira-Paulo, J., Lang, L., Teilum, K., Laganowsky, A., Benesch, J. L. P., Oliveberg, M., Robinson, C. V., Marklund, E. G., Allison, T. M., Winther, J. R. & 1 others, , 2021, In: JACS Au. 1, 12, p. 2385-2393 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5143
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In Silico prediction of mutant HIV-1 proteases cleaving a target sequence
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
270
downloads
A soluble, folded protein without charged amino acid residues
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
232
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Computational redesign of thioredoxin is hypersensitive towards minor conformational changes in the backbone template
Research output: Contribution to journal › Journal article › Research › peer-review
Published