Jakob R. Winther

Jakob R. Winther

Professor

ORCID: 0000-0001-6995-9154

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  1. Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein

    Østergaard, H., Henriksen, A., Hansen, F. G. & Winther, Jakob R., 2001, In: EMBO Journal. 20, 21, p. 5853-5862 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Monitoring disulfide bond formation in the eukaryotic cytosol

    Østergaard, H., Tachibana, C. & Winther, Jakob R., 2004, In: Journal of Cell Biology. 166, 3, p. 337-345 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Autoactivation of proteinase A initiates activation of yeast vacuolar zymogens

    van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1992, In: European Journal of Biochemistry. 207, 1, p. 277-83 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    The propeptide is required for in vivo formation of stable active yeast proteinase A and can function even when not covalently linked to the mature region

    van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1993, In: Journal of Biological Chemistry. 268, 24, p. 18002-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Random substitution of large parts of the propeptide of yeast proteinase A

    van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1995, In: Journal of Biological Chemistry. 270, 15, p. 8602-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Mutational analysis of the vacuolar sorting signal of procarboxypeptidase Y in yeast shows a low requirement for sequence conservation

    van Voorst, F., Kielland-Brandt, M. & Winther, Jakob R., 1996, In: Journal of Biological Chemistry. 271, 2, p. 841-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. The Contributions of Protein Disulfide Isomerase and Its Homologues to Oxidative Protein Folding in the Yeast Endoplasmic Reticulum

    Xiao, R., Wilkinson, B., Solovyov, A., Winther, Jakob R., Holmgren, A., Lundström-Ljung, J. & Gilbert, H. F., 2004, In: Journal of Biological Chemistry. 279, 48, p. 49780-49786 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Refolding of a carboxypeptidase Y folding intermediate in vitro by low-affinity binding of the proregion

    Winther, Jakob R., Sørensen, P. & Kielland-Brandt, M., 1994, In: Journal of Biological Chemistry. 269, 35, p. 22007-13 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Yeast carboxypeptidase Y requires glycosylation for efficient intracellular transport, but not for vacuolar sorting, in vivo stability, or activity

    Winther, Jakob R., Stevens, T. H. & Kielland-Brandt, M., 1991, In: European Journal of Biochemistry. 197, 3, p. 681-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Saccharopepsin

    Winther, Jakob R., Phylip, L. H. & Kay, J., 2004, Aspartic and Metallo Peptidases. Barrett, A. J., Rawlings, N. D. & Woessner, J. F. (eds.). 2. ed. Elsevier, p. 87-90 4 p. (Handbook of Proteolytic Enzymes, Vol. 1).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  11. Published

    Redox control: a black hole for oxidized glutathione

    Winther, Jakob R. & Jakob, U., 2013, In: Nature Chemical Biology. 9, 2, p. 69-70 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Increased hydrophobicity of the S′1 binding site in carboxypeptidase Y obtained by site-directed mutagenesis

    Winther, Jakob R., Kielland-Brandt, M. C. & Breddam, K., 1985, In: Carlsberg Research Communications. 50, 5, p. 273-284 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Quantification of thiols and disulfides

    Winther, Jakob R. & Thorpe, C., 2014, In: BBA General Subjects. 1840, 2, p. 838-846 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  14. Published

    Saccharopepsin

    Winther, Jakob R., Webb, H. & Kay, J., 2013, Handbook of Proteolytic Enzymes. Rawlings, N. D. & Salvesen, G. (eds.). Third Edition ed. Academic Press, Vol. 1. p. 128-133 6 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  15. Published

    Propeptide of carboxypeptidase Y provides a chaperone-like function as well as inhibition of the enzymatic activity

    Winther, Jakob R. & Sørensen, P., 1991, In: Proceedings of the National Academy of Sciences of the United States of America. 88, 20, p. 9330-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Functional properties of the two redox-active sites in yeast protein disulphide isomerase in vitro and in vivo

    Westphal, V., Darby, N. J. & Winther, Jakob R., 1999, In: Journal of Molecular Biology. 286, 4, p. 1229-1239 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Multiple pathways for vacuolar sorting of yeast proteinase A

    Westphal, V., Marcusson, E. G., Winther, Jakob R., Emr, S. D. & van den Hazel, H. B., 1996, In: Journal of Biological Chemistry. 271, 20, p. 11865-70 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Kinetic analysis of the mechanism and specificity of protein-disulfide isomerase using fluorescence-quenched peptides

    Westphal, V., Spetzler, J. C., Meldal, Morten Peter, Christensen, U. & Winther, Jakob R., 1998, In: Journal of Biological Chemistry. 273, 39, p. 24992-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Erv2p: characterization of the redox behavior of a yeast sulfhydryl oxidase.

    Wang, W., Winther, Jakob R. & Thorpe, C., 2007, In: Biochemistry. 46, 11, p. 3246-54 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    THE FREE SULFHYDRYL-GROUP (CYS341) OF CARBOXYPEPTIDASE-Y - FUNCTIONAL-EFFECTS OF MUTATIONAL SUBSTITUTIONS

    WINTHER, J., BREDDAM, K. & Winther, Jakob R., 1987, In: Carlsberg Research Communications. 52, 4, p. 263-273

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Positive staining for cellulose in oral pulse granuloma

    Virkkunen, S., Wolff, H., Haglund, C., Højgaard, C., Winther, Jakob R., Willemoës, Martin, Vogel, U. & Hagström, J., Apr 2017, In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 123, 4, p. 464-467 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Review: biosynthesis and function of yeast vacuolar proteases

    Van Den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1996, In: Yeast (Chichester, England). 12, 1, p. 1-16 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Mechanism and ion-dependence of in vitro autoactivation of yeast proteinase A: possible implications for compartmentalized activation in vivo

    Van Den Hazel, H., Wolff, A. M., Kielland-Brandt, M. & Winther, Jakob R., 1997, In: Biochemical Journal. 326 ( Pt 2), p. 339-44 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids

    Valls, L. A., Winther, Jakob R. & Stevens, T. H., 1990, In: Journal of Cell Biology. 111, 2, p. 361-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Active-site residues of procarboxypeptidase Y are accessible to chemical modification

    Sørensen, S. O. & Winther, Jakob R., 1994, In: BBA General Subjects. 1205, 2, p. 289-93 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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