Jakob R. Winther

Jakob R. Winther

Professor

ORCID: 0000-0001-6995-9154

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  1. Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein

    Østergaard, H., Henriksen, A., Hansen, F. G. & Winther, Jakob R., 2001, In: EMBO Journal. 20, 21, p. 5853-5862 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Monitoring disulfide bond formation in the eukaryotic cytosol

    Østergaard, H., Tachibana, C. & Winther, Jakob R., 2004, In: Journal of Cell Biology. 166, 3, p. 337-345 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Autoactivation of proteinase A initiates activation of yeast vacuolar zymogens

    van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1992, In: European Journal of Biochemistry. 207, 1, p. 277-83 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    The propeptide is required for in vivo formation of stable active yeast proteinase A and can function even when not covalently linked to the mature region

    van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1993, In: Journal of Biological Chemistry. 268, 24, p. 18002-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Random substitution of large parts of the propeptide of yeast proteinase A

    van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1995, In: Journal of Biological Chemistry. 270, 15, p. 8602-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Mutational analysis of the vacuolar sorting signal of procarboxypeptidase Y in yeast shows a low requirement for sequence conservation

    van Voorst, F., Kielland-Brandt, M. & Winther, Jakob R., 1996, In: Journal of Biological Chemistry. 271, 2, p. 841-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. The Contributions of Protein Disulfide Isomerase and Its Homologues to Oxidative Protein Folding in the Yeast Endoplasmic Reticulum

    Xiao, R., Wilkinson, B., Solovyov, A., Winther, Jakob R., Holmgren, A., Lundström-Ljung, J. & Gilbert, H. F., 2004, In: Journal of Biological Chemistry. 279, 48, p. 49780-49786 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Refolding of a carboxypeptidase Y folding intermediate in vitro by low-affinity binding of the proregion

    Winther, Jakob R., Sørensen, P. & Kielland-Brandt, M., 1994, In: Journal of Biological Chemistry. 269, 35, p. 22007-13 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Yeast carboxypeptidase Y requires glycosylation for efficient intracellular transport, but not for vacuolar sorting, in vivo stability, or activity

    Winther, Jakob R., Stevens, T. H. & Kielland-Brandt, M., 1991, In: European Journal of Biochemistry. 197, 3, p. 681-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Saccharopepsin

    Winther, Jakob R., Phylip, L. H. & Kay, J., 2004, Aspartic and Metallo Peptidases. Barrett, A. J., Rawlings, N. D. & Woessner, J. F. (eds.). 2. ed. Elsevier, p. 87-90 4 p. (Handbook of Proteolytic Enzymes, Vol. 1).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  11. Published

    Redox control: a black hole for oxidized glutathione

    Winther, Jakob R. & Jakob, U., 2013, In: Nature Chemical Biology. 9, 2, p. 69-70 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Increased hydrophobicity of the S′1 binding site in carboxypeptidase Y obtained by site-directed mutagenesis

    Winther, Jakob R., Kielland-Brandt, M. C. & Breddam, K., 1985, In: Carlsberg Research Communications. 50, 5, p. 273-284 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Quantification of thiols and disulfides

    Winther, Jakob R. & Thorpe, C., 2014, In: BBA General Subjects. 1840, 2, p. 838-846 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  14. Published

    Saccharopepsin

    Winther, Jakob R., Webb, H. & Kay, J., 2013, Handbook of Proteolytic Enzymes. Rawlings, N. D. & Salvesen, G. (eds.). Third Edition ed. Academic Press, Vol. 1. p. 128-133 6 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  15. Published

    Propeptide of carboxypeptidase Y provides a chaperone-like function as well as inhibition of the enzymatic activity

    Winther, Jakob R. & Sørensen, P., 1991, In: Proceedings of the National Academy of Sciences of the United States of America. 88, 20, p. 9330-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Functional properties of the two redox-active sites in yeast protein disulphide isomerase in vitro and in vivo

    Westphal, V., Darby, N. J. & Winther, Jakob R., 1999, In: Journal of Molecular Biology. 286, 4, p. 1229-1239 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Multiple pathways for vacuolar sorting of yeast proteinase A

    Westphal, V., Marcusson, E. G., Winther, Jakob R., Emr, S. D. & van den Hazel, H. B., 1996, In: Journal of Biological Chemistry. 271, 20, p. 11865-70 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Kinetic analysis of the mechanism and specificity of protein-disulfide isomerase using fluorescence-quenched peptides

    Westphal, V., Spetzler, J. C., Meldal, Morten Peter, Christensen, U. & Winther, Jakob R., 1998, In: Journal of Biological Chemistry. 273, 39, p. 24992-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Erv2p: characterization of the redox behavior of a yeast sulfhydryl oxidase.

    Wang, W., Winther, Jakob R. & Thorpe, C., 2007, In: Biochemistry. 46, 11, p. 3246-54 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    THE FREE SULFHYDRYL-GROUP (CYS341) OF CARBOXYPEPTIDASE-Y - FUNCTIONAL-EFFECTS OF MUTATIONAL SUBSTITUTIONS

    WINTHER, J., BREDDAM, K. & Winther, Jakob R., 1987, In: Carlsberg Research Communications. 52, 4, p. 263-273

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Positive staining for cellulose in oral pulse granuloma

    Virkkunen, S., Wolff, H., Haglund, C., Højgaard, C., Winther, Jakob R., Willemoës, Martin, Vogel, U. & Hagström, J., Apr 2017, In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 123, 4, p. 464-467 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Review: biosynthesis and function of yeast vacuolar proteases

    Van Den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1996, In: Yeast (Chichester, England). 12, 1, p. 1-16 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Mechanism and ion-dependence of in vitro autoactivation of yeast proteinase A: possible implications for compartmentalized activation in vivo

    Van Den Hazel, H., Wolff, A. M., Kielland-Brandt, M. & Winther, Jakob R., 1997, In: Biochemical Journal. 326 ( Pt 2), p. 339-44 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids

    Valls, L. A., Winther, Jakob R. & Stevens, T. H., 1990, In: Journal of Cell Biology. 111, 2, p. 361-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Active-site residues of procarboxypeptidase Y are accessible to chemical modification

    Sørensen, S. O. & Winther, Jakob R., 1994, In: BBA General Subjects. 1205, 2, p. 289-93 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    pH-dependent processing of yeast procarboxypeptidase Y by proteinase A in vivo and in vitro

    Sørensen, S. O., van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1994, In: European Journal of Biochemistry. 220, 1, p. 19-27 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    The pro region required for folding of carboxypeptidase Y is a partially folded domain with little regular structural core

    Sørensen, P., Winther, Jakob R., Kaarsholm, N. C. & Poulsen, F. M., 1993, In: Biochemistry. 32, 45, p. 12160-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Preparation of fluorescence quenched libraries containing interchain disulphide bonds for studies of protein disulphide isomerases

    Spetzler, J. C., Westphal, V., Winther, Jakob R. & Meldal, M., 1998, In: Journal of Peptide Science. 4, 2, p. 128-137 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel

    Santner, P., Martins, J. M. D. S., Laursen, J. S., Behrendt, L., Riber, Leise, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5949-5956

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Random mutagenesis analysis of the Influenza A M2 proton channel reveals novel resistance mutants

    Santner, P., Martins, J. M. D. S., Kampmeyer, Caroline, Hartmann-Petersen, Rasmus, Laursen, J. S., Stein, Amelie, Olsen, Christian Adam, Arkin, I. T., Winther, Jakob R., Willemoës, Martin & Lindorff-Larsen, Kresten, 2018, In: Biochemistry. 57, 41, p. 5957-5968

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Rational Protein Engineering to Increase the Activity and Stability of IsPETase Using the PROSS Algorithm

    Rennison, A., Winther, Jakob R. & Varrone, C., 2021, In: Polymers. 13, 22, 11 p., 3884.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Requirement of the propeptide for in vivo formation of active yeast carboxypeptidase Y

    Ramos, C., Winther, Jakob R. & Kielland-Brandt, M., 1994, In: Journal of Biological Chemistry. 269, 9, p. 7006-12 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Exchange of regions of the carboxypeptidase Y propeptide. Sequence specificity and function in folding in vivo

    Ramos, C. & Winther, Jakob R., 1996, In: European Journal of Biochemistry. 242, 1, p. 29-35 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Endoplasmic reticulum transport of glutathione by Sec61 is regulated by Ero1 and Bip

    Ponsero, A. J., Igbaria, A., Darch, M. A., Miled, S., Outten, C. E., Winther, Jakob R., Palais, G., D'Autréaux, B., Delaunay-Moisan, A. & Toledano, M. B., 21 Sep 2017, In: Molecular Cell. 67, 6, p. 962-973.e5 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. The Potency and Specificity of the Interaction between the IA3 Inhibitor and Its Target Aspartic Proteinase from Saccharomyces cerevisiae

    Phylip, L. H., Lees, W. E., Brownsey, B. G., Bur, D., Dunn, B. M., Winther, Jakob R., Gustchina, A., Li, M., Copeland, T., Wlodawer, A. & Kay, J., 2001, In: Journal of Biological Chemistry. 276, 3, p. 2023-2030 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Evidence that translation reinitiation leads to a partially functional Menkes protein containing two copper-binding sites

    Paulsen, M., Lund, C., Akram, Z., Winther, Jakob R., Horn, N. & Møller, L. B., 2006, In: American Journal of Human Genetics. 79, 2, p. 214-29 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Gene regulation in response to protein disulphide isomerase deficiency

    Nørgaard, P., Tachibana, C., Bruun, A. W. & Winther, Jakob R., 2003, In: Yeast. 20, 7, p. 645-652 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Mutation of yeast Eug1p CXXS active sites to CXXC results in a dramatic increase in protein disulphide isomerase activity

    Nørgaard, P. & Winther, Jakob R., 2001, In: Biochemical Journal. 358, 1, p. 269-274 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Functional differences in yeast protein disulfide isomerases

    Nørgaard, P., Westphal, V., Tachibana, C., Alsøe, L., Holst, B. & Winther, Jakob R., 2001, In: Journal of Cell Biology. 152, 3, p. 553-562 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Increasing protein stability by inferring substitution effects from high-throughput experiments

    Norrild, R. K., Johansson, Kristoffer Enøe, O'Shea, Charlotte, Morth, J. P., Lindorff-Larsen, Kresten & Winther, Jakob R., 2022, In: Cell Reports Methods. 2, 11, 11 p., 100333.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Trisulfides in Proteins

    Nielsen, R. W., Tachibana, C., Hansen, N. E. & Winther, Jakob R., 2011, In: Antioxidants & Redox Signaling. 15, 1, p. 67-75 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Metal-ion dependent catalytic properties of Sulfolobus solfataricus class II α-mannosidase

    Nielsen, J. W., Poulsen, N. R., Johnsson, A. M. S., Winther, Jakob R., Stipp, S. L. S. & Willemoës, Martin, 2012, In: Biochemistry. 51, 40, p. 8039-8046 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    A fluorescent probe which allows highly specific thiol labeling at low pH

    Nielsen, J. W., Jensen, K. S., Hansen, R. R. E., Gotfredsen, C. H. & Winther, Jakob R., 2012, In: Analytical Biochemistry. 421, 1, p. 115-120 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Polysaccharide effects on calcite growth: the influence of composition and branching

    Nielsen, J. W., Sand, Karina Krarup, Pedersen, C. S., Lakshtanov, L. Z., Winther, Jakob R., Willemoës, Martin & Stipp, S. L. S., 2012, In: Crystal Growth & Design. 12, 10, p. 4906-4910 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Production of a heterologous proteinase A by Saccharomyces kluyveri

    Møller, K., Tidemand, L. D., Winther, Jakob R., Olsson, L., Piskur, J. & Nielsen, J., 2001, In: Applied Microbiology and Biotechnology. 57, 1-2, p. 216-219 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Intracellular glutathione pools are heterogeneously concentrated

    Montero, D., Tachibana, C., Winther, Jakob R. & Appenzeller-Herzog, C., 2013, In: Redox Biology. 1, 1, p. 508-513 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    High-resolution imaging of redox signaling in live cells through an oxidation-sensitive yellow fluorescent protein

    Maulucci, G., Labate, V., Mele, M., Panieri, E., Arcovito, G., Galeotti, T., Østergaard, H., Winther, Jakob R., De Spirito, M. & Pani, G., 2008, In: Science Signaling. 1, 43, p. pl3 1-15 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Computational and Experimental Assessment of Backbone Templates for Computational Redesign of the Thioredoxin Fold

    Marin, Frederikke Isa, Johansson, Kristoffer Enøe, O'Shea, Charlotte, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, In: The Journal of Physical Chemistry B. 125, 40, p. 11141-11149

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Computational and experimental assessment of backbone templates for computational protein design

    Marin, Frederikke Isa, Johansson, K. E., O'Shea, Charlotte, Lindorff-Larsen, Kresten & Winther, Jakob R., 2021, 15 p.

    Research output: Working paper › Preprint › Research

  50. Published

    Kinetic and thermodynamic properties of two barley thioredoxin h isozymes, HvTrxh1 and HvTrxh2

    Maeda, K., Hägglund, Per Mårten, Björnberg, O., Winther, Jakob R. & Svensson, B., 2010, In: FEBS Letters. 584, 15, p. 3376-3380 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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