Jakob R. Winther
Professor
Biomolecular Sciences
Ole Maaløes Vej 5
2200 København N.
- Published
pH-dependent processing of yeast procarboxypeptidase Y by proteinase A in vivo and in vitro
Sørensen, S. O., van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1994, In: European Journal of Biochemistry. 220, 1, p. 19-27 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids
Valls, L. A., Winther, Jakob R. & Stevens, T. H., 1990, In: Journal of Cell Biology. 111, 2, p. 361-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Yeast carboxypeptidase Y requires glycosylation for efficient intracellular transport, but not for vacuolar sorting, in vivo stability, or activity
Winther, Jakob R., Stevens, T. H. & Kielland-Brandt, M., 1991, In: European Journal of Biochemistry. 197, 3, p. 681-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Why is DsbA such an oxidizing disulfide catalyst?
Grauschopf, U., Winther, Jakob R., Korber, P., Zander, T., Dallinger, P. & Bardwell, J. C., 1995, In: Cell. 83, 6, p. 947-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Visualization of nanofibrillar cellulose in biological tissues using a biotinylated carbohydrate binding module of β-1,4-Glycanase
Knudsen, K. B., Kofoed, Christian, Espersen, R., Højgaard, C., Winther, Jakob R., Willemoës, Martin, Wedin, I., Nuopponen, M., Vilske, S., Aimonen, K., Weydahl, I. E. K., Alenius, H., Norppa, H., Wolff, H., Wallin, E. H. R. & Vogel, U., 2015, In: Chemical Research in Toxicology. 28, 8, p. 1627-1635 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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VM i molekylære puslespil
Abildgaard, A. B., Winther, Jakob R., Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 16 Apr 2021, In: Weekendavisen: Ideer. 15, p. 11Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
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Trisulfides in Proteins
Nielsen, R. W., Tachibana, C., Hansen, N. E. & Winther, Jakob R., 2011, In: Antioxidants & Redox Signaling. 15, 1, p. 67-75 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Thiol-Disulfide Exchange between Glutaredoxin and Glutathione
Iversen, R., Andersen, P. A., Jensen, K. S., Winther, Jakob R. & Sigurskjold, B. W., 2010, In: Biochemistry. 49, 4, p. 810-820 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The thiol oxidant dipyridyl disulfide can supply the PDI-Ero1p pathway with additional oxidative equivalents.
López-Mirabal, H. R. & Winther, Jakob R., 2007, In: Antonie van Leeuwenhoek. International Journal of General and Molecular Microbiology. 92, 4, p. 463-72 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The propeptide is required for in vivo formation of stable active yeast proteinase A and can function even when not covalently linked to the mature region
van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1993, In: Journal of Biological Chemistry. 268, 24, p. 18002-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The pro region required for folding of carboxypeptidase Y is a partially folded domain with little regular structural core
Sørensen, P., Winther, Jakob R., Kaarsholm, N. C. & Poulsen, F. M., 1993, In: Biochemistry. 32, 45, p. 12160-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The pKa value and accessibility of cysteine residues are key determinants for protein substrate discrimination by glutaredoxin
Jensen, K. S., Pedersen, J. T., Winther, Jakob R. & Teilum, Kaare, 2014, In: Biochemistry. 53, 15, p. 2533-2540 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The human selenoprotein VCP-interacting membrane protein (VIMP) is non-globular and harbors a reductase function in an intrinsically disordered region
Christensen, L. C., Jensen, N. W., Lages Lino Vala, A., Kamarauskaite, J., Johansson, L. C., Winther, Jakob R., Hofmann, K., Teilum, Kaare & Ellgaard, Lars, 2012, In: Journal of Biological Chemistry. 287, 31, p. 26388-26399 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The functional role of the autolysis loop in the regulation of factor X upon hemostatic response
Bonde, A. C., Lund, J., Hansen, J. J., Winther, Jakob R., Nielsen, P. F., Zahn, S., Tiainen, P., Olsen, O. H., Petersen, H. H. & Rose Bjelke, J., 2022, In: Journal of Thrombosis and Haemostasis. 20, 3, p. 589-599 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix
Li, M., Phylip, L. H., Lees, W. E., Winther, Jakob R., Dunn, B. M., Wlodawer, A., Kay, J. & Gustchina, A., 2000, In: Nature Structural & Molecular Biology. 7, 2, p. 113-117 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
The Potency and Specificity of the Interaction between the IA3 Inhibitor and Its Target Aspartic Proteinase from Saccharomyces cerevisiae
Phylip, L. H., Lees, W. E., Brownsey, B. G., Bur, D., Dunn, B. M., Winther, Jakob R., Gustchina, A., Li, M., Copeland, T., Wlodawer, A. & Kay, J., 2001, In: Journal of Biological Chemistry. 276, 3, p. 2023-2030 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
The Contributions of Protein Disulfide Isomerase and Its Homologues to Oxidative Protein Folding in the Yeast Endoplasmic Reticulum
Xiao, R., Wilkinson, B., Solovyov, A., Winther, Jakob R., Holmgren, A., Lundström-Ljung, J. & Gilbert, H. F., 2004, In: Journal of Biological Chemistry. 279, 48, p. 49780-49786 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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THE FREE SULFHYDRYL-GROUP (CYS341) OF CARBOXYPEPTIDASE-Y - FUNCTIONAL-EFFECTS OF MUTATIONAL SUBSTITUTIONS
WINTHER, J., BREDDAM, K. & Winther, Jakob R., 1987, In: Carlsberg Research Communications. 52, 4, p. 263-273Research output: Contribution to journal › Journal article › Research › peer-review
Surprisingly high stability of barley lipid transfer protein, LTP1, towards denaturant, heat and proteases
Lindorff-Larsen, Kresten & Winther, Jakob R., 2001, In: FEBS Letters. 488, 3, p. 145-148 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Substitutional landscape of a split fluorescent protein fragment using high-density peptide microarrays
Antonescu, O. N., Rasmussen, A., Damm, N. A. M., Heidemann, Ditte Fogh, Popov, R., Nesterov-Mueller, A., Johansson, Kristoffer Enøe & Winther, Jakob R., 2021, In: PLoS ONE. 16, 2, 17 p., e0241461.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of glutaredoxin Grx1p C30S mutant from yeast.
Håkansson, K. O. & Winther, Jakob R., 2007, In: Acta Crystallographica. Section D: Biological Crystallography. 63, Pt 3, p. 288-94 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Steady state kinetic analysis of O-linked GalNAc glycan release catalyzed by endo-α-N-acetylgalactosaminidase
Hansen, D. K., Winther, Jakob R. & Willemoës, Martin, 2019, In: Carbohydrate Research. 480, p. 54-60Research output: Contribution to journal › Journal article › Research › peer-review
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Shining light on split fluorescent protein fitness landscapes using peptide array-based deep substitutional scanning
ANTONESCU, O., Johansson, Kristoffer Enøe & Winther, Jakob R., 30 Jun 2019.Research output: Contribution to conference › Poster › Research › peer-review
Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein
Østergaard, H., Henriksen, A., Hansen, F. G. & Winther, Jakob R., 2001, In: EMBO Journal. 20, 21, p. 5853-5862 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Saccharopepsin
Winther, Jakob R., Webb, H. & Kay, J., 2013, Handbook of Proteolytic Enzymes. Rawlings, N. D. & Salvesen, G. (eds.). Third Edition ed. Academic Press, Vol. 1. p. 128-133 6 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
ID: 5143
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In Silico prediction of mutant HIV-1 proteases cleaving a target sequence
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A soluble, folded protein without charged amino acid residues
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Computational redesign of thioredoxin is hypersensitive towards minor conformational changes in the backbone template
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