Jakob R. Winther

Jakob R. Winther

Professor

ORCID: 0000-0001-6995-9154

Publication year:
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  1. 1985

  2. Increased hydrophobicity of the S′1 binding site in carboxypeptidase Y obtained by site-directed mutagenesis

    Winther, Jakob R., Kielland-Brandt, M. C. & Breddam, K., 1985, In: Carlsberg Research Communications. 50, 5, p. 273-284 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 1986
  4. Published

    Mutational replacement of methionine by arginine in the S′1 substrate binding site of yeast carboxypeptidase

    Bech, L. M., Nielsen, J., Winther, Jakob R., Kielland-Brandt, M. C. & Breddam, K., 1986, In: Carlsberg Research Communications. 51, 6, p. 459-465 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 1987
  6. Published

    THE FREE SULFHYDRYL-GROUP (CYS341) OF CARBOXYPEPTIDASE-Y - FUNCTIONAL-EFFECTS OF MUTATIONAL SUBSTITUTIONS

    WINTHER, J., BREDDAM, K. & Winther, Jakob R., 1987, In: Carlsberg Research Communications. 52, 4, p. 263-273

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 1990
  8. Published

    Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids

    Valls, L. A., Winther, Jakob R. & Stevens, T. H., 1990, In: Journal of Cell Biology. 111, 2, p. 361-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 1991
  10. Published

    Propeptide of carboxypeptidase Y provides a chaperone-like function as well as inhibition of the enzymatic activity

    Winther, Jakob R. & Sørensen, P., 1991, In: Proceedings of the National Academy of Sciences of the United States of America. 88, 20, p. 9330-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Yeast carboxypeptidase Y requires glycosylation for efficient intracellular transport, but not for vacuolar sorting, in vivo stability, or activity

    Winther, Jakob R., Stevens, T. H. & Kielland-Brandt, M., 1991, In: European Journal of Biochemistry. 197, 3, p. 681-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 1992
  13. Published

    Autoactivation of proteinase A initiates activation of yeast vacuolar zymogens

    van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1992, In: European Journal of Biochemistry. 207, 1, p. 277-83 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 1993
  15. Published

    The pro region required for folding of carboxypeptidase Y is a partially folded domain with little regular structural core

    Sørensen, P., Winther, Jakob R., Kaarsholm, N. C. & Poulsen, F. M., 1993, In: Biochemistry. 32, 45, p. 12160-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The propeptide is required for in vivo formation of stable active yeast proteinase A and can function even when not covalently linked to the mature region

    van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1993, In: Journal of Biological Chemistry. 268, 24, p. 18002-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 1994
  18. Published

    Active-site residues of procarboxypeptidase Y are accessible to chemical modification

    Sørensen, S. O. & Winther, Jakob R., 1994, In: BBA General Subjects. 1205, 2, p. 289-93 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Refolding of a carboxypeptidase Y folding intermediate in vitro by low-affinity binding of the proregion

    Winther, Jakob R., Sørensen, P. & Kielland-Brandt, M., 1994, In: Journal of Biological Chemistry. 269, 35, p. 22007-13 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Requirement of the propeptide for in vivo formation of active yeast carboxypeptidase Y

    Ramos, C., Winther, Jakob R. & Kielland-Brandt, M., 1994, In: Journal of Biological Chemistry. 269, 9, p. 7006-12 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    pH-dependent processing of yeast procarboxypeptidase Y by proteinase A in vivo and in vitro

    Sørensen, S. O., van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1994, In: European Journal of Biochemistry. 220, 1, p. 19-27 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. 1995
  23. Published

    Random substitution of large parts of the propeptide of yeast proteinase A

    van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1995, In: Journal of Biological Chemistry. 270, 15, p. 8602-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Why is DsbA such an oxidizing disulfide catalyst?

    Grauschopf, U., Winther, Jakob R., Korber, P., Zander, T., Dallinger, P. & Bardwell, J. C., 1995, In: Cell. 83, 6, p. 947-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. 1996
  26. Published

    Competition between folding and glycosylation in the endoplasmic reticulum

    Holst, B., Bruun, A. W., Kielland-Brandt, M. & Winther, Jakob R., 1996, In: E M B O Journal. 15, 14, p. 3538-46 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Exchange of regions of the carboxypeptidase Y propeptide. Sequence specificity and function in folding in vivo

    Ramos, C. & Winther, Jakob R., 1996, In: European Journal of Biochemistry. 242, 1, p. 29-35 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Multiple pathways for vacuolar sorting of yeast proteinase A

    Westphal, V., Marcusson, E. G., Winther, Jakob R., Emr, S. D. & van den Hazel, H. B., 1996, In: Journal of Biological Chemistry. 271, 20, p. 11865-70 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Mutational analysis of the vacuolar sorting signal of procarboxypeptidase Y in yeast shows a low requirement for sequence conservation

    van Voorst, F., Kielland-Brandt, M. & Winther, Jakob R., 1996, In: Journal of Biological Chemistry. 271, 2, p. 841-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Review: biosynthesis and function of yeast vacuolar proteases

    Van Den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1996, In: Yeast (Chichester, England). 12, 1, p. 1-16 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. 1997

  32. Active site mutations in yeast protein disulfide isomerase cause dithiothreitol sensitivity and a reduced rate of protein folding in the endoplasmic reticulum

    Holst, B., Tachibana, C. & Winther, Jakob R., 1997, In: Journal of Cell Biology. 138, 6, p. 1229-1238 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Mechanism and ion-dependence of in vitro autoactivation of yeast proteinase A: possible implications for compartmentalized activation in vivo

    Van Den Hazel, H., Wolff, A. M., Kielland-Brandt, M. & Winther, Jakob R., 1997, In: Biochemical Journal. 326 ( Pt 2), p. 339-44 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 1998

  35. A High-Affinity Inhibitor of Yeast Carboxypeptidase Y Is Encoded by TFS1 and Shows Homology to a Family of Lipid Binding Proteins

    Bruun, A. W., Svendsen, I., Sørensen, S. O., Kielland-Brandt, M. C. & Winther, Jakob R., 1998, In: Biochemistry. 37, 10, p. 3351-3357 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Kinetic analysis of the mechanism and specificity of protein-disulfide isomerase using fluorescence-quenched peptides

    Westphal, V., Spetzler, J. C., Meldal, Morten Peter, Christensen, U. & Winther, Jakob R., 1998, In: Journal of Biological Chemistry. 273, 39, p. 24992-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Preparation of fluorescence quenched libraries containing interchain disulphide bonds for studies of protein disulphide isomerases

    Spetzler, J. C., Westphal, V., Winther, Jakob R. & Meldal, M., 1998, In: Journal of Peptide Science. 4, 2, p. 128-137 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 1999

  39. Functional properties of the two redox-active sites in yeast protein disulphide isomerase in vitro and in vivo

    Westphal, V., Darby, N. J. & Winther, Jakob R., 1999, In: Journal of Molecular Biology. 286, 4, p. 1229-1239 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Ligand recognition and domain structure of Vps10p, a vacuolar protein sorting receptor in Saccharomyces cerevisiae

    Jørgensen, M. U., Emr, S. D. & Winther, Jakob R., 1999, In: European Journal of Biochemistry. 260, 2, p. 461-469 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Protein oxidation: prime suspect found 'not guilty'

    Bader, M., Winther, Jakob R. & Bardwell, J. C. A., 1999, In: Nature Cell Biology. 1, 3, p. E57-E58

    Research output: Contribution to journal › Comment/debate › Communication

  42. 2000
  43. Published

    Purification, co-crystallization and preliminary X-ray analysis of the natural aspartic proteinase inhibitor I(A)3 complexed with saccharopepsin from Saccharomyces cerevisiae

    Badasso, M. O., Read, J. A., Dhanaraj, V., Cooper, J. B., Wood, S. P., Blundell, T. L., Dreyer, T. & Winther, Jakob R., 2000, In: Acta Crystallographica Section D: Biological Crystallography.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix

    Li, M., Phylip, L. H., Lees, W. E., Winther, Jakob R., Dunn, B. M., Wlodawer, A., Kay, J. & Gustchina, A., 2000, In: Nature Structural & Molecular Biology. 7, 2, p. 113-117 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. 2001

  46. Barley lipid transfer protein, LTP1, contains a new type of lipid-like post-translational modification

    Lindorff-Larsen, K., Lerche, M. H., Poulsen, F. M., Roepstorff, P. & Winther, Jakob R., 2001, In: Journal of Biological Chemistry. 276, 36, p. 33547-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Functional differences in yeast protein disulfide isomerases

    Nørgaard, P., Westphal, V., Tachibana, C., Alsøe, L., Holst, B. & Winther, Jakob R., 2001, In: Journal of Cell Biology. 152, 3, p. 553-562 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Mutation of yeast Eug1p CXXS active sites to CXXC results in a dramatic increase in protein disulphide isomerase activity

    Nørgaard, P. & Winther, Jakob R., 2001, In: Biochemical Journal. 358, 1, p. 269-274 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Production of a heterologous proteinase A by Saccharomyces kluyveri

    Møller, K., Tidemand, L. D., Winther, Jakob R., Olsson, L., Piskur, J. & Nielsen, J., 2001, In: Applied Microbiology and Biotechnology. 57, 1-2, p. 216-219 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein

    Østergaard, H., Henriksen, A., Hansen, F. G. & Winther, Jakob R., 2001, In: EMBO Journal. 20, 21, p. 5853-5862 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Surprisingly high stability of barley lipid transfer protein, LTP1, towards denaturant, heat and proteases

    Lindorff-Larsen, Kresten & Winther, Jakob R., 2001, In: FEBS Letters. 488, 3, p. 145-148 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. The Potency and Specificity of the Interaction between the IA3 Inhibitor and Its Target Aspartic Proteinase from Saccharomyces cerevisiae

    Phylip, L. H., Lees, W. E., Brownsey, B. G., Bur, D., Dunn, B. M., Winther, Jakob R., Gustchina, A., Li, M., Copeland, T., Wlodawer, A. & Kay, J., 2001, In: Journal of Biological Chemistry. 276, 3, p. 2023-2030 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. 2003

  54. Gene regulation in response to protein disulphide isomerase deficiency

    Nørgaard, P., Tachibana, C., Bruun, A. W. & Winther, Jakob R., 2003, In: Yeast. 20, 7, p. 645-652 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. 2004

  56. Fluorometric polyethyleneglycol-peptide hybrid substrates for quantitative assay of protein disulfide isomerase

    Christiansen, C., Hilaire, P. M. S. & Winther, Jakob R., 2004, In: Analytical Biochemistry. 333, 1, p. 148-155 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Monitoring disulfide bond formation in the eukaryotic cytosol

    Østergaard, H., Tachibana, C. & Winther, Jakob R., 2004, In: Journal of Cell Biology. 166, 3, p. 337-345 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Saccharopepsin

    Winther, Jakob R., Phylip, L. H. & Kay, J., 2004, Aspartic and Metallo Peptidases. Barrett, A. J., Rawlings, N. D. & Woessner, J. F. (eds.). 2. ed. Elsevier, p. 87-90 4 p. (Handbook of Proteolytic Enzymes, Vol. 1).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  59. The Contributions of Protein Disulfide Isomerase and Its Homologues to Oxidative Protein Folding in the Yeast Endoplasmic Reticulum

    Xiao, R., Wilkinson, B., Solovyov, A., Winther, Jakob R., Holmgren, A., Lundström-Ljung, J. & Gilbert, H. F., 2004, In: Journal of Biological Chemistry. 279, 48, p. 49780-49786 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. 2005
  61. Published

    Increasing the reactivity of an artificial dithiol-bisulfide pair through modification of the electrostatic milieu

    Hansen, R. E., Østergaard, H. & Winther, Jakob R., 2005, In: Biochemistry.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Increasing the reactivity of an artificial dithiol-disulfide pair through modification of the electrostatic milieu

    Hansen, R. E., Østergaard, H. & Winther, Jakob R., 2005, In: Biochemistry. 44, 15, p. 5899-906 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. 2006
  64. Published

    Crystallization of mutant forms of glutaredoxin Grx1p from yeast

    Håkansson, K. O., Østergaard, H. & Winther, Jakob R., 2006, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 62, 9, p. 920-922

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Evidence that translation reinitiation leads to a partially functional Menkes protein containing two copper-binding sites

    Paulsen, M., Lund, C., Akram, Z., Winther, Jakob R., Horn, N. & Møller, L. B., 2006, In: American Journal of Human Genetics. 79, 2, p. 214-29 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Measuring intracellular redox conditions using GFP-based sensors

    Björnberg, O., Ostergaard, H. & Winther, Jakob R., 2006, In: Antioxidants & Redox Signaling. 8, 3-4, p. 354-61 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Mechanistic insight provided by glutaredoxin within a fusion to redox-sensitive yellow fluorescent protein

    Björnberg, O., Østergaard, H. & Winther, Jakob R., 2006, In: Biochemistry. 45, 7, p. 2362-71 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. 2007
  69. Published

    Cytoplasmic glutathione redox status determines survival upon exposure to the thiol-oxidant 4,4'-dipyridyl disulfide.

    López-Mirabal, H. R., Thorsen, M., Kielland-Brandt, M. C., Toledano, M. B. & Winther, Jakob R., 2007, In: FEMS Yeast Research. 7, 3, p. 391-403 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Erv2p: characterization of the redox behavior of a yeast sulfhydryl oxidase.

    Wang, W., Winther, Jakob R. & Thorpe, C., 2007, In: Biochemistry. 46, 11, p. 3246-54 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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