Jakob R. Winther

Jakob R. Winther

Professor

ORCID: 0000-0001-6995-9154

Publication year:
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  1. 1985

  2. Increased hydrophobicity of the S′1 binding site in carboxypeptidase Y obtained by site-directed mutagenesis

    Winther, Jakob R., Kielland-Brandt, M. C. & Breddam, K., 1985, In: Carlsberg Research Communications. 50, 5, p. 273-284 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 1986
  4. Published

    Mutational replacement of methionine by arginine in the S′1 substrate binding site of yeast carboxypeptidase

    Bech, L. M., Nielsen, J., Winther, Jakob R., Kielland-Brandt, M. C. & Breddam, K., 1986, In: Carlsberg Research Communications. 51, 6, p. 459-465 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 1987
  6. Published

    THE FREE SULFHYDRYL-GROUP (CYS341) OF CARBOXYPEPTIDASE-Y - FUNCTIONAL-EFFECTS OF MUTATIONAL SUBSTITUTIONS

    WINTHER, J., BREDDAM, K. & Winther, Jakob R., 1987, In: Carlsberg Research Communications. 52, 4, p. 263-273

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 1990
  8. Published

    Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids

    Valls, L. A., Winther, Jakob R. & Stevens, T. H., 1990, In: Journal of Cell Biology. 111, 2, p. 361-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 1991
  10. Published

    Propeptide of carboxypeptidase Y provides a chaperone-like function as well as inhibition of the enzymatic activity

    Winther, Jakob R. & Sørensen, P., 1991, In: Proceedings of the National Academy of Sciences of the United States of America. 88, 20, p. 9330-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Yeast carboxypeptidase Y requires glycosylation for efficient intracellular transport, but not for vacuolar sorting, in vivo stability, or activity

    Winther, Jakob R., Stevens, T. H. & Kielland-Brandt, M., 1991, In: European Journal of Biochemistry. 197, 3, p. 681-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 1992
  13. Published

    Autoactivation of proteinase A initiates activation of yeast vacuolar zymogens

    van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1992, In: European Journal of Biochemistry. 207, 1, p. 277-83 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 1993
  15. Published

    The pro region required for folding of carboxypeptidase Y is a partially folded domain with little regular structural core

    Sørensen, P., Winther, Jakob R., Kaarsholm, N. C. & Poulsen, F. M., 1993, In: Biochemistry. 32, 45, p. 12160-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The propeptide is required for in vivo formation of stable active yeast proteinase A and can function even when not covalently linked to the mature region

    van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1993, In: Journal of Biological Chemistry. 268, 24, p. 18002-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 1994
  18. Published

    Active-site residues of procarboxypeptidase Y are accessible to chemical modification

    Sørensen, S. O. & Winther, Jakob R., 1994, In: BBA General Subjects. 1205, 2, p. 289-93 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Refolding of a carboxypeptidase Y folding intermediate in vitro by low-affinity binding of the proregion

    Winther, Jakob R., Sørensen, P. & Kielland-Brandt, M., 1994, In: Journal of Biological Chemistry. 269, 35, p. 22007-13 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Requirement of the propeptide for in vivo formation of active yeast carboxypeptidase Y

    Ramos, C., Winther, Jakob R. & Kielland-Brandt, M., 1994, In: Journal of Biological Chemistry. 269, 9, p. 7006-12 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    pH-dependent processing of yeast procarboxypeptidase Y by proteinase A in vivo and in vitro

    Sørensen, S. O., van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1994, In: European Journal of Biochemistry. 220, 1, p. 19-27 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. 1995
  23. Published

    Random substitution of large parts of the propeptide of yeast proteinase A

    van den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1995, In: Journal of Biological Chemistry. 270, 15, p. 8602-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Why is DsbA such an oxidizing disulfide catalyst?

    Grauschopf, U., Winther, Jakob R., Korber, P., Zander, T., Dallinger, P. & Bardwell, J. C., 1995, In: Cell. 83, 6, p. 947-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. 1996
  26. Published

    Competition between folding and glycosylation in the endoplasmic reticulum

    Holst, B., Bruun, A. W., Kielland-Brandt, M. & Winther, Jakob R., 1996, In: E M B O Journal. 15, 14, p. 3538-46 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Exchange of regions of the carboxypeptidase Y propeptide. Sequence specificity and function in folding in vivo

    Ramos, C. & Winther, Jakob R., 1996, In: European Journal of Biochemistry. 242, 1, p. 29-35 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Multiple pathways for vacuolar sorting of yeast proteinase A

    Westphal, V., Marcusson, E. G., Winther, Jakob R., Emr, S. D. & van den Hazel, H. B., 1996, In: Journal of Biological Chemistry. 271, 20, p. 11865-70 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Mutational analysis of the vacuolar sorting signal of procarboxypeptidase Y in yeast shows a low requirement for sequence conservation

    van Voorst, F., Kielland-Brandt, M. & Winther, Jakob R., 1996, In: Journal of Biological Chemistry. 271, 2, p. 841-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Review: biosynthesis and function of yeast vacuolar proteases

    Van Den Hazel, H. B., Kielland-Brandt, M. & Winther, Jakob R., 1996, In: Yeast (Chichester, England). 12, 1, p. 1-16 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. 1997

  32. Active site mutations in yeast protein disulfide isomerase cause dithiothreitol sensitivity and a reduced rate of protein folding in the endoplasmic reticulum

    Holst, B., Tachibana, C. & Winther, Jakob R., 1997, In: Journal of Cell Biology. 138, 6, p. 1229-1238 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Mechanism and ion-dependence of in vitro autoactivation of yeast proteinase A: possible implications for compartmentalized activation in vivo

    Van Den Hazel, H., Wolff, A. M., Kielland-Brandt, M. & Winther, Jakob R., 1997, In: Biochemical Journal. 326 ( Pt 2), p. 339-44 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 1998

  35. A High-Affinity Inhibitor of Yeast Carboxypeptidase Y Is Encoded by TFS1 and Shows Homology to a Family of Lipid Binding Proteins

    Bruun, A. W., Svendsen, I., Sørensen, S. O., Kielland-Brandt, M. C. & Winther, Jakob R., 1998, In: Biochemistry. 37, 10, p. 3351-3357 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Kinetic analysis of the mechanism and specificity of protein-disulfide isomerase using fluorescence-quenched peptides

    Westphal, V., Spetzler, J. C., Meldal, Morten Peter, Christensen, U. & Winther, Jakob R., 1998, In: Journal of Biological Chemistry. 273, 39, p. 24992-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Preparation of fluorescence quenched libraries containing interchain disulphide bonds for studies of protein disulphide isomerases

    Spetzler, J. C., Westphal, V., Winther, Jakob R. & Meldal, M., 1998, In: Journal of Peptide Science. 4, 2, p. 128-137 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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